New sandwich-type polymeric potassium-dicyanoargentate(I) complex: synthesis, characterization and enzymatic activity

Abstract

Coordination compounds containing dicyanoargentate(I) have remarkable biological potential due to their therapeutic antibacterial, antifungal, antibiofilm, and anticancer properties. In this study, a new dicyanoargentate(I)based complex was synthesized and characterized by various procedures (elemental, thermal, FT-IR for complex) involving crystal analysis of the complex. In addition, the biological activity of this new compound on the acetylcholinesterase (AChE) enzyme, an important enzyme for the nervous system, was investigated. When the infrared (IR) spectrum of the complex is examined, the OH vibration peak resulting from H 2 O molecules in the structure at 3948-3337 cm −1 and at 2138 cm −1 , along with a CN peak coordinated to Ag, can be seen, indicating that the mass remaining in the thermal degradation of the complex at 1000 • C is the weight corresponding to the metal mixture consisting of K + Ag (calc.: 68.06). The crystal method revealed that the complex has a sandwich-like, polymeric chemical structure with layers formed by K + cations and [Ag(CN) 2 H 2 O] − anions. Therefore, the AChE enzyme has potential therapeutic uses in improving ACh levels in brain cells, in reducing various side effects, and in improving cognitive impairment, especially in advanced Alzheimer's disease patients. In this study, the activity of this newly synthesized complex on AChE was also investigated. As a result of this research, [Ag(CN) 2 (H 2 O)K] had 0.0282 ± 0.010 µ M Ki values against AChE. The compound was therefore a good inhibitor for the AChE enzyme. This type of compound can be used for the development of novel anticholinesterase drugs.

A Silver Compound with Potential Applications as an Anticancer, Antibacterial, Antifungal, and Anti‐Alzheimer's Agent

“…Coordination compounds are obtained by linking metal atoms with bridging ligands and can have various structural properties depending on the ligands they contain. The synthesis of cyanido complexes using cyanido ligands and various transition metals has come to the fore [8–15] . Recent studies have focused on synthesizing dicyanidosilver(I) complexes considering the potential biological activity of silver.…”

“…In our previous work, we synthesized the K[Ag(CN) 2 (H 2 O)] complex (K‐22), to which CN− and H 2 O ligands are bound at low cost and high yield, and revealed its crystallographic structure. We also investigated its biological activity on acetylcholinesterase (AChE), an essential enzyme for the nervous system [15] . This study aimed to investigate the comprehensive biological activity of compound K‐22.…”

“…The synthesis of cyanido complexes using cyanido ligands and various transition metals has come to the fore. [8][9][10][11][12][13][14][15] Recent studies have focused on synthesizing dicyanidosilver(I) complexes considering the potential biological activity of silver. These complexes' antimicrobial and anticancer properties have been investigated and shown to exhibit effective biological activity.…”

“…We also investigated its biological activity on acetylcholinesterase (AChE), an essential enzyme for the nervous system. [15] This study aimed to investigate the comprehensive biological activity of compound K-22. In addition to the activity of K-22 on the BChE enzyme, its antimicrobial and anticancer activity was also investigated.…”

New dinuclear cyanido complexes with amine alcohol ligand: synthesis, characterization and biotechnological application potential

“…The cyanido complexes have different structural properties, allowing for a wide use in the field of chemistry, biology, and material chemistry [2]. The applications of these complexes have been focused on catalysis [3], nonlinear optics, ion exchange materials, gas storage [4], molecular magnets [5-9], molecular sieves [10], enzymatic [11], antibacterial [13] and anticancer activities [5, 12,13] and thermally stable materials [14][15][16][17]. Homoleptic tetracyanidonickelate(II) building block has been extensively used for the synthesis and design of different dimensional networks [1821].…”