New benzoic acid and caffeoyl derivatives with anti-inflammatory activities isolated from leaves of <i>Ilex kaushue</i>

Kakumu, Yuya; Nguyen, Thi Minh Tu; Yamauchi, Kosei; Mitsunaga, Tohru

doi:10.1080/14786419.2021.1939334

Cited by 5 publications

(2 citation statements)

References 29 publications

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“…38 Reasonable amounts of benzoic acid can promote health, as it is not only anti-inflammatory but also improves gut function. 39,40 Besides, bile acid has important regulatory effects on a variety of physiological processes related to inflammation, 41 and 7-ketodeoxycholic acid and 7a,12a-dihydroxy-3-oxo-4-cholenoic acid are classified as bile acids. Peishi Feng et al found that decreased 7-ketogenic acid in mice might aggravate colitis.…”

Section: Discussionmentioning

confidence: 99%

Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

et al. 2023

Food Funct.

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“…Benzoate, also known as benzoic acid or benzenecarboxylate was also identified in our study as a protective metabolite for gout. A recent study found that benzoic acid has anti‐inflammatory activity, 41 which may be the reason why it has a positive effect on gout.…”

Section: Discussionmentioning

confidence: 99%

Assessing the causal association between human blood metabolites and the risk of gout

Xie,

Li,

Zhang

et al. 2023

Eur J Clin Investigation

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BackgroundThe occurrence of gout is closely related to metabolism, but there is still a lack of evidence on the causal role of metabolites in promoting or preventing gout.MethodsWe applied a two‐sample Mendelian randomization (MR) analysis to assess the association between 486 serum metabolites and gout using genome‐wide association study statistics. The inverse variance weighting method was used to generate the main results, while sensitivity analyses using MR‐Egger, weighted median, Cochran's Q test, Egger intercept test, and leave‐one‐out analysis, were performed to assess the stability and reliability of the results. We also performed a metabolic pathway analysis to identify potential metabolic pathways.ResultsAfter screening, 486 metabolites were retained for MR analysis. After screening by IVW and sensitivity analysis, 14 metabolites were identified with causal effect on gout (P < 0.05), among which hexadecanedioate was the most significant candidate metabolite associated with a lower risk of gout (IVW OR = 0.50; 95% CI = 0.38–0.67; P = 1.65 × 10−6). Metabolic pathway analysis identified one pathway that may be associated with the disease.ConclusionThis MR study combining genomics with metabolomics provides a novel insight into the causal role of blood metabolites in the risk of gout, which implies that examination of certain blood metabolites would be a feasible strategy for screening populations with a higher risk of gout.

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Comparison analysis of bioactive constituents and heavy metals among original plants of Kuding tea from the genus Ilex

Liu,

Hu,

et al. 2024

Arabian Journal of Chemistry

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New benzoic acid and caffeoyl derivatives with anti-inflammatory activities isolated from leaves of Ilex kaushue

Cited by 5 publications

References 29 publications

Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

Prebiotics alleviate cartilage degradation and inflammation in post-traumatic osteoarthritic mice by modulating the gut barrier and fecal metabolomics

Assessing the causal association between human blood metabolites and the risk of gout

Comparison analysis of bioactive constituents and heavy metals among original plants of Kuding tea from the genus Ilex

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