New Aspects of Oral Viral Diseases

Scully, Crispian

doi:10.1007/978-3-642-80169-3_2

Cited by 17 publications

(10 citation statements)

References 454 publications

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“…[17] Among those, only a small fraction of HPV-infected lesions rarely proceed to malignant transformation, specially those with HPV subtypes 16,18. [18][19][20][21] Hence, these studies indicate that tumorigenic conversion requires the presence of other risk factors.…”

Section: Virusesmentioning

confidence: 87%

Oral squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations

2006

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Tumours of the head and neck comprise an important group of neoplasia, the incidence of which is increasing in many parts of the world. This increase remains high, despite all the advances in modern medicine. This malignancy is more prevalent in the developing world and unfortunately, has not received satisfactory attention as the more prevalent cancers of the developed world, like lung, breast, or colon cancer. Recent advances in diagnosis and therapeutic techniques of these lesions have yielded novel molecular targets, uncovered signal pathway dominance and advanced early cancer detection. This review covers recent advances in our understanding of the etiology, molecular changes and the possible role that genomic and proteomic research might play in the diagnosis and effective cure of this modern-day scourge.

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Section: Virusesmentioning

confidence: 87%

Oral squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations

2006

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“…This study showed higher occurrence of HCMV, EBV‐1, EBV‐2, HSV and HHV‐7 in gingival tissue from periodontitis lesions than from clinically healthy periodontal sites. Gingival tissue may be a reservoir for some members of the Herpesviridae family ( 17, 19).…”

Section: Discussionmentioning

confidence: 99%

Herpesviruses in periodontal pocket and gingival tissue specimens

Contreras¹,

Nowzari²,

Slots³

2000

Oral Microbiology and Immunology

134

142

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Human cytomegalovirus (HCMV) and Epstein-Barr virus type 1 (EBV-1) are frequently detected in crevicular fluid of deep periodontal pockets, but little or no information is available on occurrence of herpesviruses in gingival tissue. This investigation studied the presence of herpesviruses in periodontal pockets and the corresponding gingival tissues from 11 periodontally healthy and 14 periodontitis sites. A nested-polymerase chain reaction was employed to identify the presence of HCMV, EBV-1, EBV-2, herpes simplex virus, human herpesvirus (HHV)-6, HHV-7 and HHV-8 in each test sample. In healthy periodontal sites, HCMV was detected in 1 (9%) and EBV-1 in 2 (18%) pocket samples, and HCMV was detected in 2 (18%) and EBV-1 in 3 (27%) gingival tissue samples. In periodontitis lesions, HCMV was detected in 9 (64%) pocket samples and in 12 (86%) gingival tissue samples, and EBV-1 was detected in 6 (43%) pocket samples and in 11 (79%) gingival tissue samples. HHV-6 and HHV-8 were detected exclusively in gingival tissue samples. The present findings confirm the frequent presence of HCMV and EBV-1 in periodontitis lesions and suggest using gingival tissue specimens for detecting periodontal HHV-6, HHV-7 and HHV-8.

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“…HPVs are small epitheliotropic DNA viruses that can induce hyperplastic, papillomatous and verrucous squamous cell lesions in the stratified squamous epithelia of the skin and mucosa, including the oral mucosa [20][21][22][23][24] . Nearly 120 HPV genotypes have been identified, and among them HPV 16 and HPV 18 are considered to be strongly associated with the development of malignancy and are thought to be malignant, oncogenic or highrisk genotypes 25) .…”

Section: Discussionmentioning

confidence: 99%

Hyperplastic Epithelium of Oral Mucosal Lesions Associated with Denture Wearing as a Potential Reservoir of Human Papillomavirus

Erkhembaatar

Kawai

Kato

et al. 2014

J. Hard Tissue Biology.

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To date, more than 120 total types of HPV have been identified, and in a recent meta-analysis, HPV was confirmed as an independent risk factor for oral carcinoma. Some investigators have reported that HPV infection is related to certain factors, including the gender, age, alcohol consumption, smoking habit, sexual behavior and denture wearing. Denture wearing can lead to denture epulis, which is a hyperplasia of fibrous connective tissue caused by denture irritation. Recently, HPV infection was detected in the hyperplastic epithelium of denture fibroma, but it still has received little study. The objective of the present investigation, therefore, was to clarify the relationship between the hyperplastic epithelium of the denture epulis and HPV infection. DNA of 118 formalin-fixed, paraffin-embedded hyperplastic epithelium biopsies of epulis specimens was extracted. Firstly, HPV infection was detected by PCR using consensus primers. Secondary, PCR using HPV type-specific primers (low risk types 6 and 11; high risk types 16, 18 and 33) was done in positive PCR samples. HPV infection was also detected by in situ hybridization and immunohistochemical techniques. Eighteen (23.1 %) of the 78 cases of denture epulis were positive, and 2 (5.0 %) of the 40 cases of non-denture epulis were positive. The difference was statistically significant (p<0.05, using Fisher's exact test). The most frequent type of HPV found in the 14 positive samples was HPV 16. It seems that the hyperplastic epithelium of denture epulis is easily infected with viruses because the epithelium is exposed daily to traumatic irritation from dentures. These results suggest that the hyperplastic epithelium of denture epulis might be an important reservoir for HPV infection of the oral region where later HPV-associated diseases, such as oral cancer and other oral lesions, may develop.

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New Aspects of Oral Viral Diseases

Cited by 17 publications

References 454 publications

Oral squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations

Oral squamous cell carcinoma: Etiology, pathogenesis and prognostic value of genomic alterations

Herpesviruses in periodontal pocket and gingival tissue specimens

Hyperplastic Epithelium of Oral Mucosal Lesions Associated with Denture Wearing as a Potential Reservoir of Human Papillomavirus

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