Herpesviruses in periodontal pocket and gingival tissue specimens

Contreras, Adolfo; Nowzari, Hessam; Slots, Jørgen

doi:10.1034/j.1399-302x.2000.150103.x

Cited by 134 publications

(156 citation statements)

References 22 publications

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“…7,18,19 Although few studies showed similar detection rates of HCMV as in our study, there has been a wide and varied report with high levels of viruses to none in certain population with healthy periodontium. 7,9,17,18,[20][21][22][23] In CP, there have been varied reports with some studies finding very high levels of EBV and HCMV. 10,18,20,21,23 Our results showed significantly higher levels of both the HCMV and the EBV virus in CP as compared to the healthy periodontium but still was lower than the median range as quoted by Slots 2010.…”

Section: Discussionmentioning

confidence: 99%

“…The findings of the present study were at lower levels as compared to some studies done in other countries. 18,[20][21][22][23] This could also be because the detection levels may depend on the virus being in the active or latent stage. The primary infection of the host with herpesvirus is followed by a state of latency and reactivation.…”

Section: A Study Done By Contreras Et Al In American Patientsmentioning

confidence: 99%

“…22 In Greece, the prevalence of EBV and CMV was 44 and 56% in CP. 24 Chalabi et al showed the prevalence of EBV-1 and CMV in Iran patients was 78.3 and 59% respectively.…”

Section: A Study Done By Contreras Et Al In American Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

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Objective: The identification of new uncultured species and viruses supports the possibility of combination of the herpesvirus-bacterial periodontal infection for periodontitis. The paucity of data and studies with larger sample size in Indian subjects provides an unclear picture of the presence of the herpesvirus in this population. Materials and methods:This was a cross-sectional study consisting of 100 each in the healthy group and chronic periodontitis (CP) group. The subgingival plaque was collected and polymerase chain reaction was performed post deoxyribonucleic acid (DNA) extraction by using specific primers for human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV). The data were analyzed using Fisher's exact test, Mann-Whitney U test and Spearman's coefficient correlation.Results: Human cytomegalovirus and EBV viruses were significantly higher in the CP group as compare to the healthy group. A higher percentage of those with CMV positive had EBV also positive (28.3%) compared to only 9.1% of CMV negative being EBV positive in the CP group. When both the healthy and CP group in total was compared, there was a significant correlation with all clinical parameters. Conclusion:Both the viruses dominated in disease as compared to health were similar to the earlier findings. The CP group had higher pocket depth and clinical attachment loss in the virus positive subjects. These findings could suggest that 91-9620127630, e-mail: drvinayakjoshi@gmail.com virus serves as a prelude to the disease and the combination of the two viruses could play a role in the pathogenesis. Prevalence of Herpesvirus and Correlation with Clinical

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Section: Discussionmentioning

confidence: 99%

Section: A Study Done By Contreras Et Al In American Patientsmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Joshi¹,

Bhat²,

Katti³

et al. 2015

The Journal of Contemporary Dental Practice

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“…Conceivably, the complexity of the subgingival microbiota of periodontitis may favor the colonization by these "non-oral species". Several studies have reported strong associations between certain pathogens and oral bacterial such as H. pylori and Tannerella forsythia (40), as well as co-infection of herpesviruses with T. forsythia and/or Porphyromonas gingivalis (6,18) in sites with periodontitis. The etiologic role of these pathogenic species and their relationship with oral bacteria in periodontal infections is not fully understood; although these observations might suggest a possible contribution to the etiology of these diseases.…”

Section: Figurementioning

confidence: 99%

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Souto¹,

Andrade²,

Uzeda³

et al. 2006

Braz. J. Microbiol.

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The oral cavity may act as a reservoir for several pathogens related to systemic infections. Therefore, the purpose of this study was to determine the prevalence and levels of pathogenic bacteria in the subgingival biofilm of chronic periodontitis lesions and healthy periodontal sites using the checkerboard DNA-DNA hybridization technique. 200 samples of subgingival biofilm from sites with periodontitis (probing pocket depth ≥ 4 mm and /or clinical attachment level ≥ 4 mm) and 200 samples from healthy sites of 14 patients with chronic periodontitis, as well as 200 samples from 3 periodontally healthy patients were obtained. The presence and levels of 11 pathogenic bacteria were determined using whole genomic DNA probes and the checkerboard method, computed for each site and then across sites within each subject group. Significance of differences in clinical and microbiological parameters among groups were examinated using the MannWhitney and Wilcoxon sign tests. The predominant species in all 600 samples included Corynebacterium diphtheriae, Enterococcus faecalis, Staphylococcus aureus, Acinetobacter baumannii and Escherichia coli. In general, most of the species were detected in greater prevalence and levels in sites with and without disease from patients with periodontitis in comparison to the periodontally healthy group. In particular, C. diphtheriae, E. coli, E. faecalis, Pseudomonas aeruginosa and S. aureus were significantly more prevalent and detected in higher counts in diseased sites of patients with periodontal disease compared to healthy subjects (p < 0.05). Clinical signs of disease presented a positive correlation with the species A. baumannii, Streptococcus pyogenes, E. coli, S. aureus and P. aeruginosa. In conclusion, "non-oral" pathogenic bacteria are detected in high prevalence and levels in periodontal sites of chronic periodontitis patients.

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“…Also fungal species like Candida albicans (Hannula et al, 1997) are predominant in endodontic and periodontal lesions. Recently it has been found that Cytomegalo virus, Ebstein -barr virus, Herpes virus can also be the causative agents (Contreras et al, 2000).…”

Section: Etiologymentioning

confidence: 99%

Endo-Perio Symbiosis

Joshi¹,

Jain²,

Tevatia³

et al. 2017

Int.J.Curr.Res.Aca.Rev.

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Article InfoThe interrelationship between endodontic and periodontal diseases has been a subject of speculation, confusion and controversy for many years. Pulpal and periodontal problems are responsible for more than 50% of tooth mortality today. An endo-perio lesion can have a varied pathogenesis which ranges from quite simple to relatively complex one. These lesions often present challenges to the clinician as far as diagnosis and prognosis of the involved teeth are concerned. It is very essential to make a correct diagnosis so that the appropriate treatment can be provided. To make a correct diagnosis the clinician should have a thorough understanding and scientific knowledge of these lesions and may need to perform restorative, endodontic or periodontal therapy, either singly or in combination to treat them. Therefore, this paper will highlight the diagnostic, clinical guidelines and decision making in the treatment of these lesions from an endodontists point of view to achieve the best outcome.

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Herpesviruses in periodontal pocket and gingival tissue specimens

Cited by 134 publications

References 22 publications

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Prevalence of Herpesvirus and Correlation with Clinical Parameters in Indian Subjects with Chronic Periodontitis

Prevalence of "non-oral" pathogenic bacteria in subgingival biofilm of subjects with chronic periodontitis

Endo-Perio Symbiosis

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