New approaches towards the discovery and evaluation of bioactive peptides from natural resources

Developments for Collagen Hydrolysate in Biological, Biochemical, and Biomedical Domains: A Comprehensive Review

“…Collagen is one of the known biopolymeric proteins in a human body for various key biological, biochemical, and biomedical functions [ 1 , 2 ]. The proteinic structure is composed of three α (alpha) chains of amino acids ( Figure 1 a), each with a count of 1014 amino acids constituents.…”

“…The quaternary structure is formed with the intertwining of three pro-α-chains into a right-handed super helical collagen structure. The hydrogen bond of Gly contents at every third residue and hydroxyl bond of hydroxyproline are responsible for the tight helical conformation [ 2 , 4 , 5 , 6 ].…”

“…This review includes the literature on collagen hydrolysate or gelatin. The collagen is converted into hydrolysate through extraction from different sources using salt, acid, and enzymes, which cause hydrolysis or proteolysis of the natural peptides [ 2 , 4 , 5 , 6 ]. Therefore, the collagen hydrolysate is a hydrolyzed form of denatured collagen [ 7 ].…”

“…Recently, López et al highlighted the extracted sources, processes, and the potential applications for collagen as a biomaterial with low molecular weight [ 3 ]. Another recent effort by Kang et al provides a unique review on different bioactive peptides in which collagen peptides are presented as a rising option for food- and nutrition-based applications [ 2 ]. Kehinde et al provides a unique recent contribution on antidiabetics-based collagen hydrolysate [ 1 ].…”

Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment

“…Bioactive peptides can be obtained by chemical synthesis; nevertheless, the production process can be non-viable [13]. Two principal methods are used to produce bioactive peptides.…”