New Approaches Towards Monoamino Polyglycerol Dendrons and Dendritic Triblock Amphiphiles

Wyszogrodzka, Monika; Möws, Katrin; Kamlage, Stefan; Wodzińska, Joanna; Plietker, Bernd; Haag, Rainer

doi:10.1002/ejoc.200700683

Cited by 39 publications

(44 citation statements)

References 44 publications

(22 reference statements)

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“…REVIEW www.advmat.de amino PG dendrons have been synthesized by a completely divergent approach using 2-aminopropane-1,3 diol or D,L-serine. [100,101] Allylation of alcohol functionalities under phase-transfer conditions and subsequent catalytic dihydroxylation followed by catalytic hydrogenation yielded the desired generations of monoamino glycerol dendrons (Fig. 3).…”

Section: Bifuntional Glycerol Dendrons: Building Blocks For Modular Smentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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The application of nanotechnology in medicine and pharmaceuticals is a rapidly advancing field that is quickly gaining acceptance and recognition as an independent area of research called "nanomedicine". Urgent needs in this field, however, are biocompatible and bioactive materials for antifouling surfaces and nanoparticles for drug delivery. Therefore, extensive attention has been given to the design and development of new macromolecular structures. Among the various polymeric architectures, dendritic ("treelike") polymers have experienced an exponential development due to their highly branched, multifunctional, and well-defined structures. This Review describes the diverse syntheses and biomedical applications of dendritic polyglycerols (PGs). These polymers exhibit good chemical stability and inertness under biological conditions and are highly biocompatible. Oligoglycerols and their fatty acid esters are FDA-approved and are already being used in a variety of consumer applications, e.g., cosmetics and toiletries, food industries, cleaning and softening agents, pharmaceuticals, polymers and polymer additives, printing photographing materials, and electronics. Herein, we present the current status of dendritic PGs as functional dendritic architectures with particular focus on their application in nanomedicine, in drug, dye, and gene delivery, as well as in regenerative medicine in the form of non-fouling surfaces and matrix materials.

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Section: Bifuntional Glycerol Dendrons: Building Blocks For Modular Smentioning

confidence: 99%

Dendritic Polyglycerols for Biomedical Applications

et al. 2009

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“…with multiple amine-terminated groups [71], polyglycerols with polyetheric chains and hydroxyl groups [72], and silane dendrimers with carboxyl groups [73]. It is relatively easy to synthesize the dendrimers that carry dopant atoms such as phosphorus, sulfur, nitrogen or even iron [74] in addition to carbon, oxygen, and hydrogen.…”

Section: Structural Features Of Dendrimers and Dendrimer Monolayersmentioning

confidence: 99%

“…Dendritic polyglycerols is normally synthesized by the divergent method, as shown in Figure 16 [72]. The main synthesis steps contain the substitution of 2-propenyl group and formation of vicinal diol moiety by oxidation process (i.e., oxidized by using K 2 OsO 4 ).…”

Section: Structural Features Of Dendrimers and Dendrimer Monolayersmentioning

confidence: 99%

Dendrimers as Dopant Atom Carriers

Wu¹,

Dan²

2018

Dendrimers - Fundamentals and Applications

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Properties of modern semiconducting transistors and future electron or quantum devices are essentially determined by single dopant atoms. How to precisely control the individual dopant position is one of the key factors to advance these technologies. In this chapter, we first briefly introduce the research progress in single dopant devices. To fabricate single dopant devices at large scale, we then overview our previous propose to control the locations of single dopants by self-assembly of large molecules (polyglycerols) with each carrying one dopant atom. The synthesis process, doping properties, and challenges of the molecular doping technique will be thoroughly elaborated before we conclude this chapter.

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“…The reaction was cooled to 0 °C in a water-icebath. Then 1-ethyl-3- to literature procedures [31,32]. dPG amine (M n 10,000 g/mol)…”

Section: Nhs-c18-pg[g1]mentioning

confidence: 99%

Dendronized core-multishell nanocarriers for solubilization of guest molecules

Fleige¹,

Tyagi²,

Haag

2014

Nanocarriers

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We have synthesized core-multishell (CMS) nanocarriers with different outer shells and the self-aggregation behavior and the transport capacity of these nanocarriers were studied with the hydrophobic guest molecules Nile red (NR) and methotrexate (MTX). The outer shell either consisted of methoxypoly(ethylene glycol) (mPEG) or polyglycerol (PG) dendrons of generation one or two. NR was solubilized by all CMS nanocarriers. The solubilization of MTX could only be achieved with mPEG-terminated CMS nanocarriers. Depending on the encapsulated guest, the CMS nanocarriers showed self-aggregation. The NR loaded CMS nanocarriers all formed bigger aggregates with a radius between 110 and 170 nm. In the case of the MTX loaded CMS nanocarriers, the MTX prevented the formation of CMS aggregates and therefore its efficient transport

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New Approaches Towards Monoamino Polyglycerol Dendrons and Dendritic Triblock Amphiphiles

Cited by 39 publications

References 44 publications

Dendritic Polyglycerols for Biomedical Applications

Dendritic Polyglycerols for Biomedical Applications

Dendrimers as Dopant Atom Carriers

Dendronized core-multishell nanocarriers for solubilization of guest molecules

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