New approaches to the estimation of endometrial dysfunction

Aylamazyan, Edvard Karpovich; Tolibova, Gulrukhsor Kh.; Tral, Tatyana G.; Kogan, Igor Yu.; Yarmolinskaya, Maria I.; Tsipurdeeva, Anna Alekseevna; Rodichkina, Valeriia R.; Kvetnoy, I. M.

doi:10.17816/jowd6638-15

Cited by 9 publications

(3 citation statements)

References 7 publications

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“…Our data correlated with physiological impact of P on the endometrium in the middle secretory phase of the endometrial cycle. The impact conveyed itself in decrease of the ER and PR expression in the glands, and did not contradict the data of other researchers [10,18].…”

Section: Discussionsupporting

confidence: 77%

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Overexpression of estrogen and progesterone receptors as indicator of endometrial receptivity disorder in women with early miscarriage

Aganezov¹,

Эллиниди²,

Ponomarenko³

et al. 2020

Russ Open Med J

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Background ― The endometrial factor is important in miscarriage (MC) pathogenesis. Objective. To perform a morphofunctional evaluation of endometrium in the patients with uncertain MC cause in anamnesis. Material and methods ― We examined 48 women 23-40 yo [30 (27, 35)]: the main group consisted of 33 patients with early MC in their medical history, while the control group included 15 healthy fertile women. All women had an ovulatory menstrual cycle, normal levels of gonadotropic and thyroid hormones, prolactin, and androgens. Ultrasound and hormonal examinations, along with morphological investigation of endometrial biopsies were performed. Data presented as median with lower and upper quartiles – Me (LQ, UQ). Results ― In 64% (n=21) of women in the main group, we detected inferior secretory phase of their endometrial cycle, focal fibrosis of endometrial stroma; synchronous overexpression of estrogen (ER) and progesterone (PR) receptors in endometrial glands and stroma. ER in the glands was 240 (160, 280) vs. 130 (80, 210) in the stroma, while PR values were 270 (210, 290) in the glands vs. 270 (240, 280) in the stroma: differences from the control group were significant (p<0.01). Remaining women in the main group (36%, n=12) and all women in the control group had full secretory transformation of the endometrium and normal expression of ER and PR. The levels of estradiol and PR in the blood of women with early MC in anamnesis, with different variants of ER and PR expression in the endometrium, did not differ significantly from the control group and corresponded to the reference values. Conclusion ― Nearly two-thirds of women with early miscarriage in anamnesis exhibited overexpression of ER and PR in the endometrium, which may be one of the indicators of its decreased receptivity status.

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Section: Discussionsupporting

confidence: 77%

“…A comprehensive investigation of estradiol (E 2 ) and P levels in the blood, ultrasound monitoring data on "ovarian cycle" and endometrium, and the results of morphological (histological and immunohistochemical) studies of the endometrium were described by few authors [10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of estrogen and progesterone receptors as indicator of endometrial receptivity disorder in women with early miscarriage

Aganezov¹,

Эллиниди²,

Ponomarenko³

et al. 2020

Russ Open Med J

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“…№3 Vol. 3 • 2023 ISSN 2788-6190 БЕЗПЛІДДЯ Д іагностика хронічного ендометриту (ХЕ) є комплексною та включає вивчення анамнезу, аналіз клінічних симптомів, даних ультразвукового, гістероскопічного та морфологічного обстежень з оцінюванням показників місцевого імунітету [1][2][3][4][5][6][7][8][9].…”

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Morphological features of erdometrium for women with reproductive losses on a background chronic endometritis

Susidko

2023

P&R

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The objective. Analysis to investigate the morphological features of endometrium in patients without aphids with chronic endometritis. Materials and methods. Conducted a prospective investigation in women with a history of chronic endometritis and infertility. The main group - 100 women of reproductive age with chronic endometritis, the control group - 40 women of reproductive age, with supra-temporal menstruation, with a medical history of history of pregnancy and childbirth. To study the morphological characteristics of endometrium in patients with chronic endometritis, an assessment of the results of endometrial biopsy, viconanization on the 5th-7th day of the menstrual cycle was carried out using an additional aspiration curette Pipelle de Cornier (France). Statistically significant differences were taken as p<0.05. Results. Pathomorphological examination of the endometrium revealed characteristic signs of chronic inflammation - the presence of a large number of plasma cells in the stroma of the endometrium, lymphoid infiltrates near blood vessels and the mouth of glands, unevenly expressed fibrosis of the stroma, sclerotic changes in the walls of spiral arteries. All examinees had two or more morphological signs of chronic endometritis. The most common morphological sign of chronic endometritis in the main group was inflammatory infiltrates, consisting mainly of lymphoid elements, which occurred in 94.0%, respectively, and were absent in patients of the control group (p<0.001). Focal fibrosis of the endometrial stroma covered large areas in the vast majority of women in the main group and accounted for 93.0% (р<0,01). In the stroma of the endometrium, the appearance of capillary-type vessels was noted, the intensity of their development had a strong correlation with the degree of severity of inflammatory changes (r=0.69: p<0.05). Conclusions. A morphological study of the endometrium in patients with infertility, against the background of chronic endometritis, shows that inflammatory changes in the tissues have clear morphological criteria, which are most pronounced on the 5-7th day of the menstrual cycle - the presence of plasma cells, stroma fibrosis, and sclerosis of the vessel walls

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Endometrial hyperplasia in women with external genital endometriosis and uterine myoma

Tolibova¹,

Tral²,

Kakhiani³

et al. 2020

Ross. vestn. akush.-ginekol.

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New approaches to the estimation of endometrial dysfunction

Cited by 9 publications

References 7 publications

Overexpression of estrogen and progesterone receptors as indicator of endometrial receptivity disorder in women with early miscarriage

Overexpression of estrogen and progesterone receptors as indicator of endometrial receptivity disorder in women with early miscarriage

Morphological features of erdometrium for women with reproductive losses on a background chronic endometritis

Endometrial hyperplasia in women with external genital endometriosis and uterine myoma

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