New aporphine alkaloids from Beilschmiedia podagrica

Johns, SR; Lamberton, JA; Sioumis, AA; Tweeddale, HJ

doi:10.1071/ch9691277

Cited by 22 publications

(21 citation statements)

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“…(+)-Predicentrine ( 73 ), which was first prepared by O -methylation of boldine ( 74 ), was isolated together with norpredicentrine ( 75 ) from the leaves of B. podagrica . Three aporphine alkaloids, isocorydine ( 76 ), glaucine ( 77 ), and (+)- N -methyllindcarpine ( 78 ) were obtained after subsequent investigation of the leaves of the same plant while laurelliptine ( 79 ) and isoboldine ( 80 ) were obtained from the bark [ 66 , 67 ]. Laurelliptine ( 79 ) was also obtained from the bark of B. elliptica together with the pale pink needles of isoboldine ( 80 ) [ 67 , 68 ].…”

Section: Chemical Constituentsmentioning

confidence: 99%

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

et al. 2015

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Plants of the Lauraceae family are widely used in traditional medicine and are sources of various classes of secondary metabolites. Two genera of this family, Beilschmiedia and Endiandra, have been the subject of numerous investigations over the past decades because of their application in traditional medicine. They are the only source of bioactive endiandric acid derivatives. Noteworthy is that their biosynthesis contains two consecutive non-enzymatic electrocyclic reactions. Several interesting biological activities for this specific class of secondary metabolites and other constituents of the two genera have been reported, including antimicrobial, enzymes inhibitory and cytotoxic properties. This review compiles information on the structures of the compounds described between January 1960 and March 2015, their biological activities and information on endiandric acid biosynthesis, with 104 references being cited.

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Section: Chemical Constituentsmentioning

confidence: 99%

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

et al. 2015

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“…In a previous communication, we reported two new aporphine alkaloids, cathafiline (1) and cathaformine (2), along with six known compounds, actinodaphnine (3), cassythine, isoboldine, cassameridine, cassamedine, and lysicamine, from the fresh herbs of Formosan grown Cassytha filiformis. (Lauraceae) was found to exhibit significant vasorelaxant activity as well as inhibitory effects on the platelet aggregation induced by several aggregating agents.…”

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confidence: 99%

Chemical Constituents from Cassytha filiformis II

et al. 1998

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Using a bioassay-directed fractionation method, three new compounds, including an aporphine alkaloid, cassyformine (4); an oxoaporphine alkaloid, filiformine (8), and a lignan, (+)-diasyringaresinol (10), along with 14 known compounds, were further isolated and characterized from the MeOH extract of the fresh herbs of Cassytha filiformis. Among the isolates of this plant, cathafiline (1), cathaformine (2), actinodaphnine (3), N-methylactinodaphnine (5), predicentrine (6), and ocoteine (7) exhibited significant antiplatelet aggregation activity.

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“…Except for the two species in Taiwan, previous studies of nine Beilschmiedia species in the world have revealed endiandric acids [5,18,19], flavonoids [20,21], alkaloids [22–24], benzopyrans [18], arylpropanoids [25] and sesquiterpenoids [18]. Several isolates have shown antibacterial [19,21] and antimalarial [22] activities.…”

Section: Discussionmentioning

confidence: 99%

Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities

Huang

Chang

Wang

et al. 2012

IJMS

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Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (8–11), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 1–7 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC50 value of 31.70 μM.

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New aporphine alkaloids from Beilschmiedia podagrica

Cited by 22 publications

References 0 publications

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

Chemical Constituents from Cassytha filiformis II

Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities

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