New antitumor 6-chloropurine nucleosides inducing apoptosis and G2/M cell cycle arrest

Study of the N7 Regioselective Glycosylation of 6-Chloropurine and 2,6-Dichloropurine with Tin and Titanium Tetrachloride

“…16−18 An interesting cytotoxic activity of N 7 -nucleosides has also been described. 19,20 The main reason for their neglect in biological research compared to other purine nucleoside mimetics seems to be the lack of an effective and generally applicable method for the synthesis of a wide range of N 7nucleosides.…”

“…In the initial experiments, N 7 -analogues of antiviral N 9 -derivatives did not show activity, − but in subsequent publications, active antivirals were found. − Regarding the described biological effects of nucleosides, which are bound to the purine derivative via the N 7 atom, the literature thus far has only begun to scratch the surface. N 7 -Nucleosides have become of interest as inhibitors of butyrylcholinesterase, an enzyme that breaks down choline esters, including the neurotransmitter acetylcholine, therefore representing therapeutic targets, for example, in Alzheimer’s disease treatment. − An interesting cytotoxic activity of N 7 -nucleosides has also been described. , The main reason for their neglect in biological research compared to other purine nucleoside mimetics seems to be the lack of an effective and generally applicable method for the synthesis of a wide range of N 7 -nucleosides.…”

Structure–activity features of purines and their receptors: implications in cell physiopathology

“…Therefore, purine receptors represent an interesting target to design novel anticancer derivatives [ 25 ]. Some anticancer derivatives (e.g., 6-Chloropurine and 2-acetamido-6-chloropurine linked to a perbenzylated hexosyl moiety) have been designed with the purine ring system as a structural mother frame [ 106 ], and others have been designed specifically with adenine (in its nucleoside or nucleotide form) as a mother frame, due to the physiological relevance of adenosine receptors on many pathological processes, such as cancer, and cancer-related pain [ 107 , 108 ]. So far, numerous derivatives have been synthetized and are still under experimental or clinical testing.…”

Polymers with Hemiaminal Ether Linkages for pH-Responsive Antibacterial Materials

“…Bacteria-resistant coatings can be fabricated with polymers that can repel bacterial attachment . Another strategy relies on coatings formed by materials that are themselves biocides (contact-killing) or that contain biocides (release-killing). − Purine and purine nucleoside derivatives display strong antiviral, antifungal, and antibacterial activities. − 6-Chloropurine analogues are known to inhibit bacterial RNA polymerases by site-directed alkylation . To the best of our knowledge, purines have not yet been embedded by physical or chemical entrapment in coatings.…”