A LED-based cell irradiation system was built that can irradiate a 96-well plate with monochromatic light at controlled temperature and with a built-in dark control. This system was used to study the response of six human cancer cell lines to blue, green, and red light.
In this work, two new photopharmacological ruthenium prodrugs are described that can be activated by green light. Cell death occurs via apoptosis; it is not a consequence of singlet oxygen generation, but of light-induced photosubstitution reactions.
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