New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus

Lee, In‐Kyoung; Kim, Young-Sook; Jang, Yoon-Woo; Jung, Jin‐Young; Yun, Bong‐Sik

doi:10.1016/j.bmcl.2007.10.072

Cited by 132 publications

(61 citation statements)

References 11 publications

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“…In response to these, I. obliquus has evolved a complex series of integrated defense systems. In recent years, more than 20 different kinds of bioactive components have been found in I. obliquus mainly including inooidiol the precursor of vitamin D2, betulinic acid, oxygenated triterpenes (Handa et al, 2010), superoxide dismutase (SOD), trametenolic acid, dextran, tannin compounds, steroids, alkaloid, lanosterol (Nakamura et al, 2009), lanoline alkane type three terpenes, lignin, melanin catechol (Zheng et al, 2009), folic acid derivatives, sheath ammonia fat analogs, mannitol, polyphenol, lanosterol (Wang et al, 2001), half the tannin compounds, aromatic substances (Zhao and Piao, 2006;Taji et al, 2008), β-glucan (Rhee et al, 2008), peptides (Hyun et al, 2006), polysaccharides (Cui et al, 2005;Zhang et al, 2007;Nakajima et al, 2007), polyphenols (Cui et al, 2005;Lee et al, 2007), triterpenoids, and steroids (Cui et al, 2005). Some components and their effects on tumor cell can be found in Table 1.…”

Section: Inonotus Obliquus and Bioactive Constituentsmentioning

confidence: 99%

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Song¹,

Liu²,

Kong³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Inonotus Obliquus and Bioactive Constituentsmentioning

confidence: 99%

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Song¹,

Liu²,

Kong³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…New free radical scavengers, inonoblins A-C (25,43,44), were isolated from the methanolic extract of I. obliquus, along with phelligridins D (20), E (21) and G (23) (Figure 4). 51 Inonoblin A (25) was re-isolated from P. igniarius and named phelligridin I. Phellinins A1 (45) and A2 (46), Styrylpyrones from medicinal fungi and their medicinal importance I-K Lee and B-S Yun unique styrylpyrones, were isolated from the culture broth of Phellinus sp. KACC903057P, along with hispidin (1) and 1,1-distyrylpyrylethan (10).…”

Section: Structural Diversity Of Styrylpyronesmentioning

confidence: 99%

Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance

2011

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Members of the genera Phellinus and Inonotus, including P. linteus, P. igniarius, P. ribis, I. obliquus and I. xeranticus are well-known medicinal fungi (mushrooms) and have been used in treatment of cancer, diabetes, bacterial and viral infections and ulcer. Adverse effects of these medicinal mushrooms have not yet been reported, indicating the safe nature of these mushrooms. Polysaccharides, particularly b-glucan, are considered the compounds responsible for the biological activity of medicinal mushrooms. However, there is only a limited amount of evidence to indicate that polysaccharides are in fact responsible for the biological effects of these medicinal mushrooms. Recently, many research groups have begun identification of active low-MW compounds in medicinal mushrooms, with a focus on the yellow polyphenol pigments, which are composed of a styrylpyrone class of compounds. Interestingly, a representative group of medicinal fungi, including P. linteus, P. igniarius, P. ribis, I. obliquus and I. xeranticus were shown to produce a large and diverse range of styrylpyrone-type polyphenol pigments that exhibited various biological activities, including anti-oxidative, anti-inflammatory, cytotoxic, anti-platelet aggregation, anti-diabetic, anti-dementia and anti-viral effects. Styrylpyrone pigments in mushrooms are thought to have a role similar to that of flavonoids in plants. The unique and unprecedented carbon skeleton of fused styrylpyrone might be an attractive molecular scaffold for pharmacological applications. In this review, the structural diversity, biological effects and biogenesis of styrylpyrone-class polyphenols from medicinal fungi are described.

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“…These phenolic compounds may inhibit atherosclerosis and cancer (Diplock et al, 1998) (Williams et al, 1999) without considerable mutagenic effects (Ishikawa et al, 1984). Undoubtedly, the toxic effects of chemical and synthetic antioxidants such as butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) may be prevented by the use of mushrooms constituents as natural antioxidant compounds (Lee et al, 2007). For this reason, such types of natural antioxidants gained importance especially in the medical researches.…”

Section: Introductionmentioning

confidence: 99%

Some Bioactive Properties of Wild and Commercial Mushroom Species

Yıldız¹,

Yılmaz²,

Can³

et al. 2017

J Food Health Sci

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Abstract:In this study, the protein and total phenolic contents of some commercially cultivated (Agaricus bisporus, Pleurotus ostreatus) and wild mushrooms (Amanita caesarea, Fistulina hepatica, Meripilus giganteus) were determined. Antioxidant and antimicrobial properties of these mushrooms against Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Salmonella typhimurium, Acinetobacter haemolyticus, Proteus mirabilis, Pseudomonas aeruginosa and Candida albicans were also investigated. The protein contents, total phenolic contents and antioxidant activities of the mushrooms were found in the range of 11.00 -25.1%, 1.111 -3.858 mg GAE g -1 , and 1.528 -9.340 μmol FeSO4·7H2O g -1 , respectively. Meripilus giganteus had higher protein than all the tested mushrooms. The highest total phenolic content was detected in Agaricus bisporus obtained from B company (3.858 mg GAE g -1 ), whereas the lowest total phenolic content was observed in Meripilus giganteus (1.111 mg GAE g -1 ). Total phenolic and antioxidant properties of mushrooms were found significantly different (P<0.05) by Duncan's multiple range test. Methanolic extracts of the tested mushrooms showed no inhibitory activity against bacteria and yeast.

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New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus

Cited by 132 publications

References 11 publications

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Progress on Understanding the Anticancer Mechanisms of Medicinal Mushroom: Inonotus Obliquus

Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance

Some Bioactive Properties of Wild and Commercial Mushroom Species

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