New Anticancer Drugs from Cultured and Collected Marine Organisms

Fenical, William; Jensen, Paul R.; Kauffman, Christopher A.; Mayhead, Stephanie; Faulkner, D. John; Sincich, Catherine; Rao, M. Rama; Kantorowski, Eric J.; West, Lyndon M.; Strangman, Wendy K.; Shimizu, Yuzuru; Лі, Бо; Thammana, Sudhakararao; Drainville, Katherine; Davies‐Coleman, Michael T.; Kramer, Robert A.; Fairchild, Craig R.; Rose, William C.; Wild, Robert A.; Vite, Gregory D.; Peterson, Russell W.

doi:10.1080/1388020039051741

Cited by 20 publications

(12 citation statements)

References 8 publications

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“…These results give new insights into the presence of molecular machineries for the production of naringenin chalcone or resveratrol, or, at least, what their homologs do in land plants. Marine microalgae possessing type I and II PKS enzymes are already known to produce polyketides with applications in human health and biotechnology [117][118][119][120]. We demonstrated that several lineages of microalgae possess type III PKS resembling CHS/STS genes, which posed new questions on their possible functions in microalgae.…”

Section: Discussionmentioning

confidence: 90%

In Silico Identification of Type III PKS Chalcone and Stilbene Synthase Homologs in Marine Photosynthetic Organisms

Luca

Lauritano

2020

Biology

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Marine microalgae are photosynthetic microorganisms at the base of the marine food webs. They are characterized by huge taxonomic and metabolic diversity and several species have been shown to have bioactivities useful for the treatment of human pathologies. However, the compounds and the metabolic pathways responsible for bioactive compound synthesis are often still unknown. In this study, we aimed at analysing the microalgal transcriptomes available in the Marine Microbial Eukaryotic Transcriptome Sequencing Project (MMETSP) database for an in silico search of polyketide synthase type III homologs and, in particular, chalcone synthase (CHS) and stilbene synthase (STS), which are often referred to as the CHS/STS family. These enzymes were selected because they are known to produce compounds with biological properties useful for human health, such as cancer chemopreventive, anti-inflammatory, antioxidant, anti-angiogenic, anti-viral and anti-diabetic. In addition, we also searched for 4-Coumarate: CoA ligase, an upstream enzyme in the synthesis of chalcones and stilbenes. This study reports for the first time the occurrence of these enzymes in specific microalgal taxa, confirming the importance for microalgae of these pathways and giving new insights into microalgal physiology and possible biotechnological applications for the production of bioactive compounds.

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Section: Discussionmentioning

confidence: 90%

In Silico Identification of Type III PKS Chalcone and Stilbene Synthase Homologs in Marine Photosynthetic Organisms

Luca

Lauritano

2020

Biology

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“…Many algae produce sulfated polysaccharides with antioxidant, antiviral and immunostimulatory activity (Huheihel et al, 2002;Lee et al, 2006;Pugh et al, 2001;Tannin-Spitz et al, 2005;Yim et al, 2004), vitamin E (Carballo-Cardenas et al, 2003, carotenoids and other pigments with anticancer and antioxidant effects (Ebermann et al, 1996;Moreau et al, 2006) and various toxins exhibiting cytotoxic, antiviral, antibacterial and antifungal activities. Several large screening programs of bioprospecting with algal extracts have been performed or are ongoing to identify bioactive compounds of medical significance (Døskeland, 2001;Fenical et al, 2003;Gerwick et al, 1994;Scholz and Liebezeit, 2006;Ö rdög et al, 2004). As discussed below, most of these important substances are secondary metabolites, and the possibility of combinatorial biosynthesis for heterologous expression of their genes have been reviewed (Julsing et al, 2006).…”

Section: Module 4 -Extraction Of Health Promoting Biomoleculesmentioning

confidence: 98%

BioCO2 – A multidisciplinary, biological approach using solar energy to capture CO2 while producing H2 and high value products

Skjånes

Lindblad

Muller

2007

Biomolecular Engineering

180

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Many areas of algae technology have developed over the last decades, and there is an established market for products derived from algae, dominated by health food and aquaculture. In addition, the interest for active biomolecules from algae is increasing rapidly. The need for CO(2) management, in particular capture and storage is currently an important technological, economical and global political issue and will continue to be so until alternative energy sources and energy carriers diminish the need for fossil fuels. This review summarizes in an integrated manner different technologies for use of algae, demonstrating the possibility of combining different areas of algae technology to capture CO(2) and using the obtained algal biomass for various industrial applications thus bringing added value to the capturing and storage processes. Furthermore, we emphasize the use of algae in a novel biological process which produces H(2) directly from solar energy in contrast to the conventional CO(2) neutral biological methods. This biological process is a part of the proposed integrated CO(2) management scheme.

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“…These grants involved both academia and the pharmaceutical industry, with in this case, NIH/NCI involvement. The NCDDG consortium that discovered halimide (68) was led by the Fenical group at the Scripps Oceanographic Institution in La Jolla California, with a report covering their initial results published in 2000 [56]. Fenical and Jensen set up the small company Nereus to further develop agents from the NCDDG and other microbial sources.…”

Section: Plinabulin Clinical Trialsmentioning

confidence: 99%

Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents

Giddings

Newman²

2022

Marine Drugs

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Marine environments are underexplored terrains containing fungi that produce a diversity of natural products given unique environmental pressures and nutrients. While bacteria are commonly the most studied microorganism for natural products in the marine world, marine fungi are also abundant but remain an untapped source of bioactive metabolites. Given that their terrestrial counterparts have been a source of many blockbuster antitumor agents and anti-infectives, including camptothecin, the penicillins, and cyclosporin A, marine fungi also have the potential to produce new chemical scaffolds as leads to potential drugs. Fungi are more phylogenetically diverse than bacteria and have larger genomes that contain many silent biosynthetic gene clusters involved in making bioactive compounds. However, less than 5% of all known fungi have been cultivated under standard laboratory conditions. While the number of reported natural products from marine fungi is steadily increasing, their number is still significantly lower compared to those reported from their bacterial counterparts. Herein, we discuss many varied cytotoxic and anti-infective fungal metabolites isolated from extreme marine environments, including symbiotic associations as well as extreme pressures, temperatures, salinity, and light. We also discuss cultivation strategies that can be used to produce new bioactive metabolites or increase their production. This review presents a large number of reported structures though, at times, only a few of a large number of related structures are shown.

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New Anticancer Drugs from Cultured and Collected Marine Organisms

Abstract: This paper provides an outline of a collaborative research project

Cited by 20 publications

References 8 publications

In Silico Identification of Type III PKS Chalcone and Stilbene Synthase Homologs in Marine Photosynthetic Organisms

In Silico Identification of Type III PKS Chalcone and Stilbene Synthase Homologs in Marine Photosynthetic Organisms

BioCO2 – A multidisciplinary, biological approach using solar energy to capture CO2 while producing H2 and high value products

Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents

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