New angiotensin-converting enzyme inhibitory peptide from Coix prolamin and its influence on the gene expression of renin-angiotensin system in vein endothelial cells

Chen, Peiyao; Huo, Xiaoqian; Qiao, Liansheng; Zhang, Yanling; Chen, Zujun; Wang, Lingzhi

doi:10.1016/j.jcs.2020.103099

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…Chen et al [32] reported that peptides having IC50 values between 0.32 and 1000 µM were deemed to have the potential to lower blood pressure. Compared with other reported ACE-inhibiting peptides, the ACE inhibitory activity of polypeptide VW-7 was stronger than that of VDMF (IC50: 382.28 µM) extracted from Coix prolamin [33], but weaker than that of VTPVGVPKW (IC50: 1.8 µM) extracted from Black Cumin seeds [14]. The features of ACE inhibitory peptides have been outlined in various studies.…”

Section: Ace Inhibitory Activity Of Synthesized Peptidementioning

confidence: 93%

Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis

Wu¹,

Luo

Zhang

et al. 2023

Nutrients

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Torreya grandis meal has a high protein content and an appropriate amino acid ratio, making it an excellent protein source for producing ACE inhibitory peptides. To promote its application in food, medicine, and other fields, an alkaline protease hydrolysate of Torreya grandis was used in this study to isolate and identify a novel angiotensin-converting enzyme inhibitory peptide, VNDYLNW (VW-7), using ultrafiltration, gel chromatography purification, LC-MS/MS, and in silico prediction. The results show that the IC50 value of VW-7 was 205.98 µM. The Lineweaver–Burk plot showed that VW-7 had a mixed-type inhibitory effect on ACE. Meanwhile, according to the results of molecular docking, VW-7 demonstrated a strong affinity for ACE (binding energy −10 kcal/mol). VW-7 was bound to ACE through multiple binding sites. In addition, VW-7 could remain active during gastrointestinal digestion in vitro. Nitric oxide (NO) generation in human endothelial cells could rise after receiving a pretreatment with VW-7. These results indicated that Torreya grandis meal protein can be developed into products with antihypertensive function, and VW-7 has broad application prospects in the field of antihypertensive.

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Section: Ace Inhibitory Activity Of Synthesized Peptidementioning

confidence: 93%

Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis

Wu¹,

Luo

Zhang

et al. 2023

Nutrients

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“…Adlay peptides involve a multi-regulatory mechanism that regulates blood pressure, especially high angiotensin I converting enzyme (ACE) inhibitory activity. Tetrapeptide VDMF significantly downregulates ACE, AngII type 1 receptor, and ACE2 mRNA expression, while upregulating Mas gene expression [ 68 ].…”

Section: Action Pathway Against Disease Of Adlaymentioning

confidence: 99%

“…Glutelin, gluten [6,67,68] Preventive heart disease Assembled gene sets by the levels of prolamin and vitamin E biosynthesis-associated protein; blood lipid-reducing and anti-oxidant effects.…”

Section: Gastroprotectionmentioning

confidence: 99%

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Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Zeng

Yang²,

Chen

et al. 2022

Molecules

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Medicinal and food homologous adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) plays an important role in natural products promoting human health. We demonstrated the systematic actional mechanism of functional ingredients in adlay to promote human health, based on the PubMed, CNKI, Google, and ISI Web of Science databases from 1988 to 2022. Adlay and its extracts are rich in 30 ingredients with more than 20 health effects based on human and animal or cell cultures: they are anti-cancer, anti-inflammation, anti-obesity, liver protective, anti-virus, gastroprotective, cardiovascular protective, anti-hypertension, heart disease preventive, melanogenesis inhibiting, anti-allergy, endocrine regulating, anti-diabetes, anti-cachexia, osteoporosis preventive, analgesic, neuroprotecting, suitable for the treatment of gout arthritis, life extending, anti-fungi, and detoxifying effects. Function components with anti-oxidants are rich in adlay. These results support the notion that adlay seeds may be one of the best functional foods and further reveal the action mechanism of six major functional ingredients (oils, polysaccharides, phenols, phytosterols, coixol, and resistant starch) for combating diseases. This review paper not only reveals the action mechanisms of adding adlay to the diet to overcome 17 human diseases, but also provides a scientific basis for the development of functional foods and drugs for the treatment of human diseases.

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“…Food-derived peptides play a significant role in the prevention of hypertension. Recently, numerous antihypertensive peptides are isolated from different food sources such as milk [ 80 ], casein [ 81 , 82 ], egg white ovotransferrin [ 22 ], rice bran [ 1 ], wheat [ 83 ], soybean [ 84 ], potato [ 85 ], turmeric and ginger [ 9 ], quinoa [ 62 ], black cumin [ 86 ], coix [ 87 ], pistachio [ 88 ], hazelnut [ 89 ], mung bean [ 90 ], lentil [ 91 ], seahorse [ 92 ], egg white from ostrich [ 93 ], chum salmon [ 94 ], skate [ 95 ], cuttlefish [ 96 ], Sipuncula [ 97 ], bighead carp [ 98 ], shrimp ( Pandalus borealis ) [ 79 ], and beef [ 99 ]. The isolated dietary protein-derived peptides have been demonstrated to exhibit antihypertensive activities through influencing various molecular mechanisms including inhibition of angiotensin-converting enzyme (ACE), reduction of SBP, decrease of angiotensin II levels and AT1R expression, enhancing vasodilation, improving central blood pressure and arterial stiffness, and inhibition of vasoconstriction via PPAR- γ expression [ 9 , 79 , 84 , 90 ].…”

Section: The Role Of Dietary Bioactive Peptides In Hypertensionmentioning

confidence: 99%

Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders

Qiao

Chen

et al. 2021

Oxidative Medicine and Cellular Longevity

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Bioactive peptides (BPs) are fragments of 2–15 amino acid residues with biological properties. Dietary BPs derived from milk, egg, fish, soybean, corn, rice, quinoa, wheat, oat, potato, common bean, spirulina, and mussel are reported to possess beneficial effects on redox balance and metabolic disorders (obesity, diabetes, hypertension, and inflammatory bowel diseases (IBD)). Peptide length, sequence, and composition significantly affected the bioactive properties of dietary BPs. Numerous studies have demonstrated that various dietary protein-derived BPs exhibited biological activities through the modulation of various molecular mechanisms and signaling pathways, including Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element in oxidative stress; peroxisome proliferator-activated-γ, CCAAT/enhancer-binding protein-α, and sterol regulatory element binding protein 1 in obesity; insulin receptor substrate-1/phosphatidylinositol 3-kinase/protein kinase B and AMP-activated protein kinase in diabetes; angiotensin-converting enzyme inhibition in hypertension; and mitogen-activated protein kinase and nuclear factor-kappa B in IBD. This review focuses on the action of molecular mechanisms of dietary BPs and provides novel insights in the maintenance of redox balance and metabolic diseases of human.

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New angiotensin-converting enzyme inhibitory peptide from Coix prolamin and its influence on the gene expression of renin-angiotensin system in vein endothelial cells

Cited by 8 publications

References 20 publications

Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis

Purification, Identification, and Inhibitory Mechanisms of a Novel ACE Inhibitory Peptide from Torreya grandis

Actional Mechanisms of Active Ingredients in Functional Food Adlay for Human Health

Roles of Dietary Bioactive Peptides in Redox Balance and Metabolic Disorders

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