New and efficient routes to CpRe(CO)3 substituted steroids

Abstract

Two new methods for the formation of CpRe(CO) 3 substituted steroids are presented; both imply a one-pot procedure involving a transmetallation process.

Synthesis, Cytotoxicity, and COMPARE Analysis of Ferrocene and [3]Ferrocenophane Tetrasubstituted Olefin Derivatives against Human Cancer Cells

“…Another class demonstrates the enthusiasm researchers have for grafting metallocenes and metal carbonyls to a variety of biomolecules to modify their biological effects. [12] These therapeutic bioconjugates include steroidal [13][14][15] and nonsteroidal [16][17][18][19][20][21][22][23] endocrine modulators, natural products, [24][25][26][27] and others. [28][29][30][31][32][33][34] In these cases, the often covalently grafted organometallic unit is usually inert to ligand substitution, but potentiates the activity of the biomolecule via modification of the pharmacokinetic profile or acts as a structural mimic.…”

Preparation and characterization of rhenium(I) compounds with amino ester derivatized diimine ligands. Investigations of luminescence. Crystal structures of Re(CO)3Cl(pyca-β-Ala-OEt) and Re(CO)3Cl(pyca-l-Asp(OMe)-OMe)

“…Various biological classes of compounds have been examined including steroids [2,3], sugars [4,5], nucleobases [6,7], and receptor molecules [8]. The diverse properties available to organometallic compounds, including paramagnetism [9], the infrared spectra of metal carbonyls [10], photoinduced electron transfer [11], and c-emission [12] or b-emission [13] from radioactive nuclei, provide hope that novel bioconjugates could be used as biomarkers or for therapeutic purposes.…”

Steroids: reactions and partial synthesis

“…New methods have been reported 19 for the formation of cyclopentadienylrhenium carbonyl [CpRe(CO) 3 ] substituted steroids, e.g. 4.…”