New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents

Ziakas, G.; Rekka, Eleni A.; Gavalas, Antonis; Eleftheriou, Phaedra; Kourounakis, Panos N.

doi:10.1016/j.bmc.2006.04.030

Cited by 53 publications

(31 citation statements)

References 28 publications

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“…Imbalance between these two will result in damage of the cells and the outcome is known on oxidative stress. Oxidative stress is involved in various diseases including cancer, ischemia-reperfusion injury, atherosclerosis, cardiovascular diseases, inflammation, and neurodegenerative disorders (Lamson and Brignall, 1999;Flamm et al, 1978;Green and Shuaib, 2006;Vivekananthan et al, 2003;Ziakas et al, 2006;Mattson, 2003;Stavrovskaya and Kristal 2005). Thus, antioxidants have wide variety of therapeutic applications.…”

Section: Superoxide (Omentioning

confidence: 99%

Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones

2010

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Synthesis, antioxidant activity, and quantitative structure-activity relationship (QSAR) of 25 of chalcone derivatives is reported here. They were synthesized by Claisen-Schmidt reaction and were characterized by FTIR, NMR, and mass spectroscopy. Antioxidant activity is evaluated through four different methods namely, superoxide radical-scavenging, hydrogen peroxide scavenging, reducing power, and DPPH radical-scavenging assays. Generally, compounds with -SCH 3 and -OCH 3 in the para position of the A-ring and -OH in the B-ring were more active than others. In few cases some of the compounds were more active than ascorbic acid or butylated hydroxytoluene. QSAR was developed correlating the antioxidant activity with the structural features of the compounds and the predictive capability of the models was estimated using internal and external validation methods. All the predictions were within the 99% confidence level. Spatial, structural, and lipophilic properties of the compounds determine their antioxidant properties.

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Section: Superoxide (Omentioning

confidence: 99%

Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones

2010

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“…The ditertbutylphenol group of compound 5h, well described in the literature for its antioxidant activities [42], and the presence of hydroxy groups on the phenyl ring of compound 5k and 5l induced excellent antioxidant activities Table 1 Antioxidant activity and LDH release of derivatives 5aem. 50 : Concentration in mM of compounds that increased the control lag phase by 1.5 times.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Antioxydant activity of β-carboline derivatives in the LDL oxidation model

Hadjaz

Besret

Martin-Nizard

et al. 2011

European Journal of Medicinal Chemistry

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“…ROS have a great influence in progress, development, and complication of this process; therefore it is commonly assumed that drugs with antioxidant activity will have a potential anti-inflammatory effect (Delaporte et al, 2002;Geronikaki & Gavalas, 2006). Most of the steroidal and nonsteroidal drugs available on the market have a potent anti-inflammatory activity, but they also present many side effects (Geronikaki & Gavalas, 2006;Ziakas et al, 2006). The search of novel and low toxicity compounds with antioxidant and anti-inflammatory activity is now focused on natural products (Geronikaki & Gavalas, 2006;Conforti et al, 2008).…”

Section: Carrageenan-induced Rat Paw Edema Modelmentioning

confidence: 99%