Antioxidant and anti-inflammatory activities of<i>Pittocaulon</i>species from México

Marín-Loaiza, J. Camilo; Nieto‐Camacho, Antonio; Céspedes, Carlos L.

doi:10.3109/13880209.2012.718352

Cited by 6 publications

(5 citation statements)

References 40 publications

(40 reference statements)

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“…The reaction was stopped with the addition of 20 μL of H 2 SO 4 (2M) and the Abs was measured a microplate reader using a BioTek Microplate Reader Synergy HT (BioTek Instruments, Winooski, VT, USA) at 405 nm. MPO activity was expressed as optical density/biopsy [ 54 ].…”

Section: Methodsmentioning

confidence: 99%

Mexican Propolis: A Source of Antioxidants and Anti-Inflammatory Compounds, and Isolation of a Novel Chalcone and ε-Caprolactone Derivative

et al. 2018

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The propolis produced by bees are used in alternative medicine for treating inflammation, and infections, presumably due to its antioxidant properties. In this context, five propolis from México were investigated to determine their inhibitory lipid peroxidation properties. The ethyl acetate extract from a red propolis from Chiapas State (4-EAEP) was the most potent (IC50 = 1.42 ± 0.07 μg/mL) in the TBARS assay, and selected for further studies. This extract afforded two new compounds, epoxypinocembrin chalcone (6), and an ε-caprolactone derivative (10), as well as pinostrobin (1), izalpinin (2), cinnamic acid (3), pinocembrin (4), kaempherol (5), 3,3-dimethylallyl caffeate in mixture with isopent-3-enyl caffeate (7a + 7b), 3,4-dimethoxycinnamic acid (8), rhamnetin (9) and caffeic acid (11). The HPLC profile, anti-mycobacterial, and antioxidant properties of this extract was also determined. Most of the isolated compounds were also tested by inhibition of reactive oxygen species (ROS) in challenged mouse bone marrow-derived mast cells (BMMCs), and DPPH. Their anti-inflammatory activity was evaluated by TPA, and MPO (myeloperoxidase) activity by ear edema test in mice. The most potent compounds were 7a + 7b in the TBARS assay (IC50 = 0.49 ± 0.06 μM), and 2 which restored the ROS baseline (3.5 μM). Our results indicate that 4-EAEP has anti-oxidant, and anti-inflammatory properties due to its active compounds, suggesting it has anti-allergy and anti-asthma potential.

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Section: Methodsmentioning

confidence: 99%

Mexican Propolis: A Source of Antioxidants and Anti-Inflammatory Compounds, and Isolation of a Novel Chalcone and ε-Caprolactone Derivative

et al. 2018

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“…The reaction was stopped with the addition of 20 μL of H 2 SO 4 (2 M) and the absorbance was measured in a microplate reader (BioTek Microplate Reader, Winooski, VT) at 405 nm. MPO activity was expressed as optical density/biopsy (Guzmán‐Gutiérrez et al, ; Marín‐Loaiza, Nieto‐Camacho, & Céspedes, ).…”

Section: Methodsmentioning

confidence: 99%

Antinociceptive, anti‐inflammatory, and central nervous system (CNS) effects of the natural coumarin soulattrolide

Alonso-Castro

Guzmán-Gutiérrez

Betancourt

et al. 2018

Drug Development Research

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Soulattrolide is a natural coumarin synthesized by the leaves of species of Calophyllum (Calophyllaceae) rain forest trees, including the American C. brasiliense, and the Asian C. teysmanii. Soulattrolide is a potent inhibitor of the reverse transcriptase from HIV‐1 (RT‐HIV‐1), and active against Mycobacterium tuberculosis. However, the effects of this coumarins on other systems, remains to be evaluated. C. brasiliense is used in traditional medicine for the treatment of pain and inflammation. Therefore, we decided to explore the antinociceptive, anti‐inflammatory activity of soulattrolide in mice, as well as, some of its possible effects on the CNS. Soulattrolide showed antinociceptive effects in the writhing test (ED50 = 33.8 mg/kg), as well as, in the formalin test with an ED50 = 7.9, and 22.1 mg/kg for Phases 1 and 2, respectively. The highest dose of soulattrolide (50 mg/kg) induced 40% of antinociception in the hot plate test. Regarding to anti‐inflammatory activity, in the 12‐O‐Tetradecanoylphorbol‐13‐acetate (TPA) test, soulattrolide showed an IC50 = 1.81 μmol/ear, whereas in the myeloperoxidase assay, it showed an inhibition of 87% (1 μmol/ear). Soulattrolide showed sedative effects on the pentobarbital‐induced sleeping time test, and the rotarod test, but lacked antidepressant activity on the tail suspension test. In conclusion, we report for the first time, the antinociceptive effects of soulattrolide in mice, like those of naproxen; soulattrolide also showed mild anti‐inflammatory activity, as well as mild sedative and anxiolytic properties, therefore, it has also activity on the CNS.

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“…The historical folk use of this plant is to treat rheumatism and antiinflammatory ailments [ 180 ]. The chemical composition of Pittocaulon has been described, and pyrrolizidine alkaloids were identified in the five species of its genus [ 181 , 182 ], whereas sesquiterpenois with eremophilane skeletons were found in P. praecox, P. bombycophole , P. velatum and P. filare species [ 178 ]. Regarding the traditional uses of this plant as medicine, P. praecox, P. velatum, P. bombycophole and P. hintonii species demonstrated antibacterial and antifungal activity [ 182 ].…”

Section: Preclinical Studies Of Mexican Medicinal Plants Used In Inflammatory and Neuropathic Pain Treatmentmentioning

confidence: 99%

“…Regarding the traditional uses of this plant as medicine, P. praecox, P. velatum, P. bombycophole and P. hintonii species demonstrated antibacterial and antifungal activity [ 182 ]. On the other hand, extracts of P. velatum and a methanolic extract of P. bombycophole inhibited 12-O-tetradecanoylphorbol 13-acetate (TAP)-induced ear edema, presumably through an antioxidant effect, as demonstrated in the thiobarbituric acid reactive substances (TBARS) assay [ 181 ]. In the same study, the carrageenan test—a model characterized by inflammation and hyperalgesia—was used to test the anti-inflammatory effect of dichloromethane extracts of the roots of different species of Pittocaulon (100 mg/kg).…”

Section: Preclinical Studies Of Mexican Medicinal Plants Used In Inflammatory and Neuropathic Pain Treatmentmentioning

confidence: 99%

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Quiñonez-Bastidas

Navarrete

2021

Plants

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Despite the availability of many anti-pain drugs, in the form of NSAIDs, steroids, gabapentinoids, opioids, and antidepressants, in this study we address the natural compounds belonging to the group of Mexican medicinal plants or “Mexican folk medicine”, used for pain management in Mexico. Our interest in this subject is due to the growing idea that “natural is harmless” and to the large number of side effects exhibited in pharmacotherapy. The objective of this review was to document the scientific evidence about Mexican medicinal plants and their derivatives used for inflammatory and neuropathic pain treatment, as well as the mechanisms of action implicated in their antinociceptive effects, their possible adverse effects, and the main pharmacological aspects of each plant or compound. Our data review suggested that most studies on Mexican medicinal plants have used inflammatory experimental models for testing. The anti-pain properties exerted by medicinal plants lack adverse effects, and their toxicological assays report that they are safe to consume; therefore, more studies should be performed on preclinical neuropathic pain models. Moreover, there is no convincing evidence about the possible mechanisms of action involved in the anti-pain properties exerted by Mexican plants. Therefore, the isolation and pharmacological characterization of these plant derivatives’ compounds will be important in the design of future preclinical studies.

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Antioxidant and anti-inflammatory activities ofPittocaulonspecies from México

Cited by 6 publications

References 40 publications

Mexican Propolis: A Source of Antioxidants and Anti-Inflammatory Compounds, and Isolation of a Novel Chalcone and ε-Caprolactone Derivative

Mexican Propolis: A Source of Antioxidants and Anti-Inflammatory Compounds, and Isolation of a Novel Chalcone and ε-Caprolactone Derivative

Antinociceptive, anti‐inflammatory, and central nervous system (CNS) effects of the natural coumarin soulattrolide

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

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