New Alkaloids and a Tetraflavonoid from Cephalotaxus wilsoniana

Wang, Liwen; Su, Huey‐Jen; Yang, Sheng‐Zehn; Won, Shen‐Jeu; Lin, Chun‐Nan

doi:10.1021/np0498657

Cited by 39 publications

(26 citation statements)

References 7 publications

(19 reference statements)

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“…This fraction was selected because it showed the strongest antihyperglycemic tendency. The major peaks (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) in the HPLC chromatogram of FC exhibited characteristic UV maximum absorbance of flavonoids, namely, two maximum absorbance bands: band I (300-400 nm), band II (220-280 nm) (Fig. 5A).…”

Section: Structural Elucidation Of Compoundsmentioning

confidence: 99%

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Antihyperglycemic Effect of Cephalotaxus sinensis Leaves and GLUT-4 Translocation Facilitating Activity of Its Flavonoid Constituents

Dai

et al. 2007

Biological & Pharmaceutical Bulletin

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Type 1 diabetes and type 2 diabetes (T2D) rank highly among the top 10 causes of mortality throughout the world. Diabetes patients, particularly those with T2D are at considerable risk of excessive morbidity and mortality from cardiovascular, cerebrovascular, and peripheral vascular diseases leading to myocardial infarction, strokes, and amputations. 1)With the rapid advancements in medicine, novel treatments with fewer side effects have become feasible for the long-term control of this disorder. Recent scientific investigation has confirmed the efficacy of many of plant medicines on diabetes mellitus (DM), some of which are remarkably effective.2) The recommendation of the WHO committee on DM encouraged research on hypoglycemic agents of plant origin used in Chinese traditional medicine and it has greatly motivated research in this area. 3)Insulin-stimulated glucose utilization is the major site for regulation of plasma glucose concentrations.4) Glucose transport is the rate-limiting step in carbohydrate metabolism.5) A family of glucose transporters (GLUT) mediates glucose transport across the cell membrane, and the subtype 4 form (GLUT-4) is the insulin sensitive glucose transporter. Reduction in insulin-mediated glucose uptake caused by decreasing GLUT-4 protein in diabetes, especially T2D, was observed. 6,7) Compounds that facilitate GLUT-4 translocation can be potentially beneficial for the treatment of diabetes, especially for T2D.Cephalotaxus sinensis (REHD et WILE) LI, a medicinal plant and widely distributed in southern China, has been used as a Chinese traditional medicine for treatment of dyspepsia, ascariasis, inflammation, and cough. 8) Alkaloids, flavonoids, biflavonoids, and diterpenes were reported to be constituents of Cephalotaxus species.9-11) It was reported that the ester type alkaloids possessed antitumour activity. 8)Recently, osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana NAKAI (Cephalotaxaceae) have been reported. 12)To the best of our knowledge, there are no reports on the antihyperglycemic activity of C. sinensis in the literature. As part of a series of experiments to obtain natural products with antidiabetic efficacy from plants, the antihyperglycemic activity of various fractions of the ethanol extract of C. sinensis leaves were evaluated in chronic STZ-induced diabetic rats. The activity of the isolated compounds from the fraction was estimated at the cellular level in vitro. The study elucidated for the first time the biologic properties, namely the activity of facilitating GLUT-4 translocation, of the fraction and its flavonoid constituents from C. sinensis. Furthermore, we characterized the main components of the fraction by using phytochemical and HPLC-DAD methods. HPLC-DAD Conditions An Elite P230 series HPLC-DAD system consisting of a binary pump and a DAD detector (Elite DAD230, P. R. China) was used for acquiring chromatograms and UV spectra. The HPLC condition was as follows: column, Diamonsil TM C 18 column (5 mm, 250ϫ4.6 mm, Di...

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Section: Structural Elucidation Of Compoundsmentioning

confidence: 99%

“…8) Alkaloids, flavonoids, biflavonoids, and diterpenes were reported to be constituents of Cephalotaxus species. [9][10][11] It was reported that the ester type alkaloids possessed antitumour activity. 8) Recently, osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana NAKAI (Cephalotaxaceae) have been reported.…”

mentioning

confidence: 99%

Antihyperglycemic Effect of Cephalotaxus sinensis Leaves and GLUT-4 Translocation Facilitating Activity of Its Flavonoid Constituents

Dai

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Investigations of the chemical constituents of extracts of Cephalotaxus sps. resulted in the isolation of lactones, flavonoids and a number of alkaloids [7][8][9]. Recently, osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana Nakai (Cephalotaxaceae) have been reported [10].…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of Cephalotaxus sinensis

Saeed

Deng

Dai

2008

J. Clin. Biochem. Nutr.

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Summary Cephalotaxus sinensis (C. sinensis) large size, evergreen tree common in China and utilized for numerous effective pharmacological applications in Chinese traditional medicine. The hepato-renal effects of C. sinensis were evaluated in vivo using Streptozotocin (STZ)-induced diabetic rats as an tentative model. Animals were orally treated with 80% EtOH extract (aq.EE), H2O extract (WtE) and ethylacetate (EaF)/butanol fractions (BtF) of C. sinensis (200 mg/kg, b.w.) for 28 days whereas control received vehicle merely. The degree of fortification was measured by using biochemical parameters like serum transaminases (ALT and AST), alkaline phosphatase (ALP), creatinine, urea and urine sugar. Meanwhile, the histopathological studies were conducted out to support the above parameters. Administration of C. sinensis aq.EE/BtF (p<0.05) and EaF (p<0.01) patently prevented STZ-induced elevation levels of serum ALT, AST, ALP, creatinine, urea, urine sugar and increase body weight respectively, which were comparable with the standard drug tolbutamide, while WtE did not show any significant effect (p>0.05). Phytochemical studies revealed the presence of saponins, terpenes, sterols and flavonoids in C. sinensis which could be responsible for the possible hepato-renal protective action. The results sustain the fact that the extract/fractions of C. sinensis have an immense potential to be developed further into a phytomedicine.

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“…The phytochemical and toxicological studies of Kuo et al [14], Wang et al [15] and Politi et al [16] have suggested that flavonoids, biflavonoids, alkaloids, and diterpenes are the likely active components of Cephalotaxus species. Recently, osteoblast differentiation stimulating activity of biflavonoids from Cephalotaxus koreana Nakai (Cephalotaxaceae) has been reported [17].…”

Section: Introductionmentioning

confidence: 99%

Chromatographic fingerprint analysis of Cephalotaxus sinensis from various sources by high-performance liquid chromatography–diodearray detection–electrospray ionization-tandem mass spectrometry

Deng

Dai

et al. 2007

Journal of Pharmaceutical and Biomedical Analysis

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New Alkaloids and a Tetraflavonoid from Cephalotaxus wilsoniana

Cited by 39 publications

References 7 publications

Antihyperglycemic Effect of Cephalotaxus sinensis Leaves and GLUT-4 Translocation Facilitating Activity of Its Flavonoid Constituents

Antihyperglycemic Effect of Cephalotaxus sinensis Leaves and GLUT-4 Translocation Facilitating Activity of Its Flavonoid Constituents

Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of <i>Cephalotaxus sinensis</i>

Chromatographic fingerprint analysis of Cephalotaxus sinensis from various sources by high-performance liquid chromatography–diodearray detection–electrospray ionization-tandem mass spectrometry

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