New advances strategies for surface functionalization of iron oxide magnetic nano particles (IONPs)

Nosrati, Hamed; Salehiabar, Marziyeh; Davaran, Soodabeh; Ramazani, Ali; Manjili, Hamidreza Kheiri; Danafar, Hossein

doi:10.1007/s11164-017-3084-3

Cited by 76 publications

(48 citation statements)

References 170 publications

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“…Thus, surface coating and functionalization of the MNPs is necessary for decreasing the NPs aggregation and for successful uses for technological and biomedical applications . Coating and modification of the surface of MNPs with various biocompatible and biodegradable materials has been widely studied . One of the molecules that can be used for the surface modification of the MNPs are the amino acids due to inexpensive, nontoxic and biocompatible features .…”

Section: Introductionmentioning

confidence: 99%

“…10 Coating and modification of the surface of MNPs with various biocompatible and biodegradable materials has been widely studied. [11][12][13] One of the molecules that can be used for the surface modification of the MNPs are the amino acids due to inexpensive, nontoxic and biocompatible features. 14 Previously, we produced biocompatible amino acid coated MNPs for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

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Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

Nosrati

Mojtahedi

Danafar

et al. 2018

J Biomedical Materials Res

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In this study, magnetic nanoparticles (MNPs) coated with glycine (F-Gly NPs) and conjugated with methotrexate (MTX) (F-Gly-MTX NPs) were synthesized through a coprecipitation method followed by amidation reaction between the carboxylic acid end groups on MTX and the amine groups on the MNPs surface and studied its cytotoxic effect in vitro. The successful conjugating of MTX onto the nanoparticles (NPs) was confirmed by X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, vibrating sample magnetometer, and transmission electron microscopy techniques. The results showed that the average size was 46.82 ± 5.03 nm. This target drug delivery system is dependent on the release of the MTX within the lysosomal compartment. Hemolysis assay and cytotoxicity study results on HFF-2 and HEK-293 cell lines show that as prepared MNPs are biocompatible. The cytotoxicity of void of the MTX and F-Gly-MTX NPs were compared to each other by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay of the treated MCF-7 cell line. Enzymatic release studies exhibited the release of the MTX via peptide bond cleavage in the presence of proteinase K. These studies specify that the F-Gly-MTX NPs have a very remarkable anticancer effect, for breast cancer cell line. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1646-1654, 2018.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

Nosrati

Mojtahedi

Danafar

et al. 2018

J Biomedical Materials Res

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“…Bare IONPs have considerable toxic effects towards all investigated cell lines . For successful use of IONPs for technological and biomedical applications, a main requisite is surface coating and specific modification . As different biomolecules show different characteristics, it is always challenging to develop a surface modification process which carefully balances the intermolecular force between the biomolecule and the outer layer of IONPs .…”

Section: Introductionmentioning

confidence: 99%

“…As different biomolecules show different characteristics, it is always challenging to develop a surface modification process which carefully balances the intermolecular force between the biomolecule and the outer layer of IONPs . For in vivo medical applications, the coating material should be non‐toxic and biocompatible . The molecules that coat the IONP surfaces also significantly determine the interactions between the IONPs and living systems, for example their interaction with blood and the body's immune system .…”

Section: Introductionmentioning

confidence: 99%

“…The molecules that coat the IONP surfaces also significantly determine the interactions between the IONPs and living systems, for example their interaction with blood and the body's immune system . Also, functionalization of IONPs makes available functional groups to bond biologically active substances for nano bio‐applications . One type of molecules that can be used for the surface stabilization, modification and coating of IONPs are amino acids (AAs) due to their inexpensive, non‐toxic and biocompatible features.…”

Section: Introductionmentioning

confidence: 99%

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Green and one‐pot surface coating of iron oxide magnetic nanoparticles with natural amino acids and biocompatibility investigation

Nosrati

Salehiabar

Attari

et al. 2017

Applied Organom Chemis

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We report the synthesis of iron oxide magnetic nanoparticles (IONPs) coated with various natural amino acids (AAs) using a one‐pot reaction in an aqueous medium. Several AAs, which contained hydrophilic and hydrophobic groups, were selected to study their effects on size, morphology and toxicity of IONPs. Functionalized IONPs were characterized using X‐ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and scanning and transmission electron microscopies. Furthermore, vibrating sample magnetometry analysis shows these nanoparticles have excellent magnetic properties. Cellular toxicity of IONPs was also investigated on HFF2 cell lines. The AA‐coated IONPs are non‐toxic and biocompatible. Natural AA‐coated IONPs show a potential for their development in in vitro and in vivo biomedical fields due to their non‐toxicity, good ζ‐potential and related small size and narrow size distribution.

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Methods and Principles of Functionalization

2019

Functional Synthetic Polymers

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New advances strategies for surface functionalization of iron oxide magnetic nano particles (IONPs)

Cited by 76 publications

References 170 publications

Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

Green and one‐pot surface coating of iron oxide magnetic nanoparticles with natural amino acids and biocompatibility investigation

Methods and Principles of Functionalization

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