Green and one‐pot surface coating of iron oxide magnetic nanoparticles with natural amino acids and biocompatibility investigation

Abstract

We report the synthesis of iron oxide magnetic nanoparticles (IONPs) coated with various natural amino acids (AAs) using a one‐pot reaction in an aqueous medium. Several AAs, which contained hydrophilic and hydrophobic groups, were selected to study their effects on size, morphology and toxicity of IONPs. Functionalized IONPs were characterized using X‐ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and scanning and transmission electron microscopies. Furthermore, vibrating sample magnetometry analysis shows these nanoparticles have excellent magnetic properties. Cellular toxicity of IONPs was also investigated on HFF2 cell lines. The AA‐coated IONPs are non‐toxic and biocompatible. Natural AA‐coated IONPs show a potential for their development in in vitro and in vivo biomedical fields due to their non‐toxicity, good ζ‐potential and related small size and narrow size distribution.

Enzymatic stimuli‐responsive methotrexate‐conjugated magnetic nanoparticles for target delivery to breast cancer cells and release study in lysosomal condition

“…F-Gly NPs were synthesized by the one pot synthesis method. 15 Ferric chloride hexahydrate (FeCl 3 Á6H 2 O) of 1.11 g and 0.4 g of ferrous chloride tetrahydrate (FeCl 2 Á4H 2 O) (molar ratio 2:1, respectively) were dissolved in 150 mL deionized water and the mixture was stirred vigorously (12000 rpm) under N 2 atmosphere at 608C for 15 min. After 15 min, 0.82 g of glycine rapidly added to the mixture and the reaction was stirred for another 20 min.…”

“…The F-Gly NPs were synthesized by controlled coprecipitation of Fe (II) and Fe (III) ions according to the previously reported method. 15 The F-Gly NPs afterward conjugated with MTX by covalent bonding via carbodiimide chemistry. Although, the MTX conjugation may occur through either a or g carboxylic acid groups on the glutamic acid residue.…”

“…One of the molecules that can be used for the surface modification of the MNPs are the amino acids due to inexpensive, nontoxic and biocompatible features . Previously, we produced biocompatible amino acid coated MNPs for biomedical applications …”

“…14 Previously, we produced biocompatible amino acid coated MNPs for biomedical applications. 15,16 One of the highest obstacles in chemotherapy of cancer is the biodistribution of the chemotherapeutic compound, which can lead to severe off-target side effects and toxicities, so they still represent a major drawback for their administration. 17 To address these limitations, an smart method is to develop a carrier that can selectively deliver cytotoxic doses of drugs to the tumor cells.…”

Evaluation of UiO‐66 metal organic framework as an effective sorbent for Curcumin's overdose

“…The most varieties of nanoparticles have been synthesized, including polymeric nanoparticles (i.e. hydrogels), solid lipid nanoparticles (SLN), carbon nanotubes, metallic nanoparticles and metal organic framework (MOF) …”