New Advances in Iron Metabolism, Ferritin and Hepcidin Research

Arosio, Paolo

doi:10.3390/ijms232314700

Cited by 3 publications

(1 citation statement)

References 13 publications

(13 reference statements)

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“…Ferritin levels surge as an acute-phase reactant, potentially mirroring the magnitude of this inflammatory maelstrom ( 22 ). This systemic inflammation, indelibly etched into the post-stroke biological response, not only augments neuronal injury but also potentially precipitates a series of systemic repercussions that might influence overall survival ( 23 ). Moreover, when dissecting the relationship between ferritin and oxidative stress, the pivotal role of iron, encapsulated within ferritin’s molecular embrace, comes to the forefront.…”

Section: Discussionmentioning

confidence: 99%

The association between ferritin levels and all-cause mortality in stroke patients

Xia,

Liu,

Fang

et al. 2024

Front. Neurol.

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PurposeThe purpose of study was to describe the association between ferritin and all-cause mortality of cases with stroke.MethodsClinical data derived from Multiparameter Intelligent Monitoring in Intensive Care were analyzed. The primary endpoint was 30-day mortality. The potential prognostic roles of Ferritin L were analyzed by Cox proportional hazard models. The independent prognostic roles of Ferritin L in the cases were analyzed by smooth curve fitting.ResultsConcerning 30-day mortality, the HR (95% CI) for a high Ferritin (≥373) was 1.925 (1.298, 2.854; p = 0.00113), compared to a low ferritin (< 373). After adjusting for multiple confounders, the HR (95% CI) for a high Ferritin (≥373) was 1.782 (1.126, 2.820; p = 0.01367), compared to a low Ferritin (< 373). A non-linear association between Ferritin and 30-day mortality was found. Using recursive algorithm and two-piecewise linear regression model, inflection point (IP) was calculated, which was 2,204. On the left side of the IP, there was a positive relationship between Ferritin and 30-day mortality, and the effect size, 95% CI and p value were 1.0006 (1.0004, 1.0009) p < 0.0001, respectively. On the right of the IP, the effect size, 95% CI and p value were 1.0000 (1.0000, 1.0000) and 0.3107, respectively.ConclusionFerritin was associated with increased risk of stroke; it is important to further examine the association if the increased uric acid would increase the outcome of stroke in a longitudinal study. The non-linear relationship between Ferritin and all-cause mortality of stroke was observed. Ferritin was a risk factor for the outcome of stroke when ferritin was <2204.

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Section: Discussionmentioning

confidence: 99%

The association between ferritin levels and all-cause mortality in stroke patients

Xia,

Liu,

Fang

et al. 2024

Front. Neurol.

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The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment

Wang,

Zhang,

Bai

et al. 2024

Neurochem Res

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Ferroptosis and myocardial ischemia-reperfusion: mechanistic insights and new therapeutic perspectives

Jin,

Zhang,

Zhang

et al. 2024

Front. Pharmacol.

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Myocardial ischemia-reperfusion injury (MIRI) is a significant factor in the development of cardiac dysfunction following a myocardial infarction. Ferroptosis, a type of regulated cell death driven by iron and marked by lipid peroxidation, has garnered growing interest for its crucial involvement in the pathogenesis of MIRI.This review comprehensively examines the mechanisms of ferroptosis, focusing on its regulation through iron metabolism, lipid peroxidation, VDAC signaling, and antioxidant system dysregulation. We also compare ferroptosis with other forms of cell death to highlight its distinct characteristics. Furthermore, the involvement of ferroptosis in MIRI is examined with a focus on recent discoveries concerning ROS generation, mitochondrial impairment, autophagic processes, ER stress, and non-coding RNA regulation. Lastly, emerging therapeutic strategies that inhibit ferroptosis to mitigate MIRI are reviewed, providing new insights into potential clinical applications.

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New Advances in Iron Metabolism, Ferritin and Hepcidin Research

Cited by 3 publications

References 13 publications

The association between ferritin levels and all-cause mortality in stroke patients

The association between ferritin levels and all-cause mortality in stroke patients

The Role of Ferroptosis in Amyotrophic Lateral Sclerosis Treatment

Ferroptosis and myocardial ischemia-reperfusion: mechanistic insights and new therapeutic perspectives

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