Ferroptosis and myocardial ischemia-reperfusion: mechanistic insights and new therapeutic perspectives
Binwei Jin,
Zhiming Zhang,
Yang Zhang
et al.
Abstract:Myocardial ischemia-reperfusion injury (MIRI) is a significant factor in the development of cardiac dysfunction following a myocardial infarction. Ferroptosis, a type of regulated cell death driven by iron and marked by lipid peroxidation, has garnered growing interest for its crucial involvement in the pathogenesis of MIRI.This review comprehensively examines the mechanisms of ferroptosis, focusing on its regulation through iron metabolism, lipid peroxidation, VDAC signaling, and antioxidant system dysregulat… Show more
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