New Adjacent Bis-Tetrahydrofuran Annonaceous Acetogenins fromAnnona muricata

Abstract

Bioactivity-guided fractionation led to the isolation of two new Annonaceous acetogenins, annocatacin A ( 1). and annocatacin B ( 2). from the seeds and the leaves, respectively, of Annona muricata. Compounds 1 and 2 are the first examples where the adjacent bis-tetrahydrofuran ring system is located at C-15. The new structures were elucidated and characterized by spectral and chemical methods. Both Annonaceous acetogenins 1 and 2 showed significant in vitro cytotoxicity toward the human hepatoma cell lines, Hep G2 and 2,2,15, and were compared with the known adjacent bis-tetrahydrofuran acetogenins, neoannonin ( 3). desacetyluvaricin ( 4). bullatacin ( 5). asimicin ( 6). annoglaucin ( 7). squamocin ( 8). and rollimusin ( 9).

Antinociceptive and anti-ulcerogenic activities of the ethanolic extract of Annona muricata leaf

“…In addition, A. muricata leaf extract possesses antioxidant (Baskar et al,2007) and molluscicidal properties (Santos & Sant`Ana, 2001;Luna et al, 2006). Recent studies also showed anti-infl ammatory and analgesic properties in the leaves of the plant (Roslida et al, 2010;De Sousa et al, 2010) Among the chemical constituents found in the leaf of A. muricata are alkaloids (Le Bouef et al, 1981;1982), essential oils (Pélissler et al, 1994;Kossouh et al, 2007) and acetogenins (Wu et al, 1995a;1995b;1995c;1995d;Zeng et al, 1996;Chang et al,2003).…”

Phytochemical Analysis and Antibacterial Activity of Annona muricata (Laxman phal) against ESBLs Producers (Escherichia coli and Klebsiella pneumoniae)

“…According to Parbha Pathak et al, (2010) most susceptible bacteria was K. pneumoniae with Annona muricata leaves extract. Isolation of two new Annonaceous acetogenins, annocatacin A and annocatacin B from the seeds and the leaves which is proved to be which showed in-vitro cytotoxicity towards human hepatoma cell lines (Chang et al, 2003). The plant possess the major pharmacological activities includes cytotoxic, antileishmanial, wound healing, anti-microbial activity (Geetalaxmi et al, 2012).…”

PROFIL KADAR MDA PADA TUMOR KULIT MENCIT (Mus musculus) SEBAGAI AKIBAT PEMBERIAN EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L) DAN EKSTRAK METANOL BENALU TEH (Scurulla atropurpurea Bl. Dancer)

“…Sirsak (Annona muricata L.) adalah salah satu tanaman yang bermanfaat untuk mengatasi berbagai penyakit. Hasil riset menunjukkan bahwa sirsak mampu menyembuhkan sakit jantung, asma, masalah liver (hati), dan rematik (Widyaningrum, 2011) serta mampu menyembuhkan berbagai kanker maupun tumor (Adewole, 2006;Chang, 2003;Wu et al, 2001). Hal ini dimungkinkan karena sirsak mengandung tanin, alkaloid, dan flavonoid (Kardinan, 2004).…”