New Acetophenone and Cardanol Derivatives From Knema pachycarpa

Abstract

Two new acetophenone derivatives named knepachycarpanone A (1) and knepachycarpanone B (2) together with a new cardanol derivative named knepachycarpanol C (3) were isolated from the EtOAc extract of Knema pachycarpa stems. Their chemical structures were established on the basis of spectral evidences. Compounds 1 and 2 exhibited moderate cytotoxicity against Hela cancer cell line with IC50 values of 26.92 ± 1.46 and 30.20 ± 1.97 μM, respectively.

New Acetophenones and Chromenes from the Leaves of Melicope barbigera A. Gray

“…Figure S33 shows the significant effect of the cytotoxic compounds 2 and 4 on the activation of caspase 3/7, which is essential in the induction and execution of apoptosis [ 41 ]. Taken together, our results are confirming the previously reported bioactivities of acetophenones [ 40 , 42 , 43 , 44 ]. Moreover, we also found that acetophenone derivatives containing prenyl substituents show particularly higher cytotoxic activities compared to other compounds not bearing such structure elements.…”

Phenolic compounds from knema pachycarpa leaves

“…Chemical investigation of the ethyl acetate extract of K. pachycarpa leaves led to the isolation of seven phenolic compounds including six flavonoids 5,7,3′-trihydroxy-5′-methoxy isoflavone (1), luteolin (2),(-)-narigenin (3), (+)-catechin (4), isoquercetrin (5), nicotiflorin (6) and a biphenyl compound 3,3',4,4'-tetrahydroxybiphenyl (7). Compounds 3 and 6-7 were isolated from Knema genus for the first time.…”

“…Plant Knema pachycarpa de Wilde, that is called "Mau cho trai day", is a native tree in Viet Nam and only few chemical studies of this Knema species have been reported by our group [5][6][7]. In our biological activity screening of Vietnamese plants, the MeOH extract of leaves of K. pachycarpa showed cytotoxic activity against KB cell line with IC 50 of 78.21 ± 4.35 g/mL.…”

“…In the continuation of our study on Knema plants, herein the chemical constituents of K. pachycarpa leaves were described. Seven phenolic compounds were isolated and elucidated as 5,7,3′-trihydroxy-5′-methoxy isoflavone (1), luteolin (2),(-)-narigenin (3), (+)-catechin (4), isoquercetrin (5), nicotiflorine (6), and 3,3',4,4'-tetrahydroxybiphenyl (7) by NMR and MS spectral data. The isolated compounds were evaluated for cytotoxicity against several cancer cell lines.…”

Secondary metabolites from leaves of Knema pachycarpa possessing cytotoxic and acetylcholinesterase inhibitory activities

“…[1,[3][4][5][6] Knema pachycarpa de Wilde "Mau cho trai day" is a native tree in Vietnam and only few chemical studies of this Knema species have been reported. In the continuation of our study on Knema species, [7][8][9][10] the chemical constituents of Knema pachycarpa leaves were investigated. Ten compounds were isolated and elucidated as (7''R, 8''R)-hydnocarpin D (1), (7''R, 8''R)-hydnocarpin (2), sinaicitin (3), (-)-globulol (4), β-caryolanol (5), phytol (6), biochanin A (7), chrysoeriol (8), tanoside II (9) and astragalin (10) by analysis of NMR and MS spectral data.…”