Nevus Spilus and Melanoma: Case Report and Review of the Literature

Corradin, Maria Teresa; Zattra, Edoardo; Fiorentino, Renzo; Alaibac, Mauro; Fortina, Anna Belloni

doi:10.2310/7750.2009.08090

Cited by 21 publications

(38 citation statements)

References 55 publications

(63 reference statements)

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“…Generalized type has been reported which has also been associated with other anomalies especially vascular malformations (phakomatosis pigmentovascularis type III) . The possibility of a malignant degeneration of the darker speckles was raised by some authors . Regular monitoring of NS appears to be essential.…”

Section: Clinical Indicationsmentioning

confidence: 99%

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Passeron

Genedy

Salah

et al. 2019

Acad Dermatol Venereol

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Background Lasers and intense pulsed light sources (IPLS) are proposed for the treatment of many pigmentary disorders. They are sometimes considered as magic tools able to remove any type of lesions. Although being the best option for several hyperpigmented lesions, they can also worsen some conditions and have potential side‐effects. Objective The aim of this review was to give evidence‐based recommendations for the use of lasers and IPLS in the treatment of hyperpigmented lesions. Methods These recommendations were produced for the European Society of Laser Dermatology by a consensus panel made up of experts in the field of pigment laser surgery. Recommendations on the use of lasers and light treatments were made based on the quality of evidence for efficacy, safety, tolerability, cosmetic outcome, patient satisfaction/preference and, where appropriate, on the experts' opinion. Results Lasers and IPLS are very effective for treating many hyperpigmented lesions such as lentigos, dermal hypermelanocytosis or heavy metal depositions. In the other hand, they have to be considered with great caution for other disorders, such as café au lait macules, melasma or postinflammatory hyperpigmentation. After making the correct diagnosis, if lasers or IPLS are indicated, the optimal wavelengths and parameters will be chosen taking into account the skin phototype, origin and depth of the target pigments. Conclusion Although potentially very effective, lasers and IPLS cannot be proposed for all types of hyperpigmented lesions. In all cases, precise recognition of the disorder is mandatory for choosing between these devices and other therapeutic approaches.

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Section: Clinical Indicationsmentioning

confidence: 99%

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Passeron

Genedy

Salah

et al. 2019

Acad Dermatol Venereol

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“…Malignant melanoma has been reported as a very rare complication, but a renewed interest in this entity has occurred following the report, in the last 5 years, of 12 cases of malignant melanoma in NS previously considered as benign naevus, besides the previous 19 case reports of malignant melanoma on NS since the 1970s 1–10 …”

mentioning

confidence: 99%

Report of 27 cases of naevus spilus in 2134 patients with melanoma: is naevus spilus a risk marker of cutaneous melanoma?

Manganoni¹,

Pavoni

Farisoglio

et al. 2011

Acad Dermatol Venereol

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epidermis. These features might be related to a block in the S phase of the cell cycle. On the other hand, the calprotectin immunolabelling throughout the epidermis appeared strikingly motheaten indicating severe vacuolar alterations. As seen in other disorders, the Mac 387-positive keratinocytes were either metabolically altered or engaged in a regenerative phase. The combination of these features was interpreted as a sublethal sign. The dermal dendrocyte alterations were reminiscent of the methotrexate-induced changes. 6 In some instances, CAR associated with anti-cancer treatment may be predictive for the drug efficacy. 7 Such a feature has not been evaluated so far for pemetrexed.

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“…Overlying hypertrichosis has been occasionally reported, and a small case series describes coarse hairs mainly arising from the background pigmented area [70]. The development of melanoma is thought to be rare, although a recent case report was published of a 64-year-old woman who developed nodular achromic melanoma within a nevus spilus [71]. We recommend longitudinal serial examinations and excision of atypical lesions or areas of clinical change.…”

Section: Other Pigmented Lesionsmentioning

confidence: 99%

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

2012

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Pigmented lesions and melanocytic nevi are commonly evaluated lesions in pediatric dermatology clinics and the rising incidence of melanoma has increased public awareness of malignant potential. Diagnosis and management of pigmented lesions, especially dysplastic nevi, medium and large congenital melanocytic nevi (CMN), and Spitz nevi, can be particularly challenging. We summarize the recent literature for melanocytic nevi and pigmented lesions as relevant to the practice of pediatric dermatology with particular attention to dermatoscopic techniques, histopathologic interpretation, molecular biology, and management recommendations for CMN and Spitz nevi.

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Nevus Spilus and Melanoma: Case Report and Review of the Literature

Abstract: Our observation is consistent with the idea that this entity in some circumstances may have the ability to evolve into a malignant melanoma.

Cited by 21 publications

References 55 publications

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology

Report of 27 cases of naevus spilus in 2134 patients with melanoma: is naevus spilus a risk marker of cutaneous melanoma?

Literature Update on Melanocytic Nevi and Pigmented Lesions in the Pediatric Population

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