Nevus of Ota With Contralateral Cerebral Melanoma

Malignant Melanoma in a Hispanic Male with Nevus of Ota

“…The primary melanoma was ipsilatcral to the nevus in 97%. The only case where a primary mel anoma was contralateral to the nevus occurred in the CNS [22]. Six patients presented with cutaneous primary malig nant melanoma [21,[23][24][25], all arising within the nevus of Ota.…”

“…Two patients were described with ipsilateral increase in intraocular pressure by applana tion tonometry consistent with open-angle glaucoma [5,17], These melanomas arose in the iris [ 17] and choroid [5]. Two other patients [ 11,22] had an increase in their ipsilat eral intraocular pressure without a change in visual acuity. Orbital lesions frequently presented with unilateral exoph thalmos [25.…”

“…Generally, the disease has been local, with therapy (sur gery) directed at local control. Radiation therapy has been reported in 4 patients for unresectable disease [22], for local recurrence [34] and as adjuvant to surgery [32, present case].…”

“…The frequency of ipsilateral primary melano mas in the region of the nevus of Ota and in deeper struc tures involved with melanocytosis is 100%. In this review 148 Shaffer/Walkcr/Weiss Nevus of Ota and Malignant Melanoma we found that the patients with CNS primary melanomas had extensive melanocytosis of the meninges [14,21,22,31,33,35,36], patients with orbital primary melanoma had melanocytosis involving orbital structures [17. 26-29, 37], and patients with a cutaneous primary developed their melanoma in skin affected by nevus of Ota [10,15,[23][24][25].…”

“…26-29, 37], and patients with a cutaneous primary developed their melanoma in skin affected by nevus of Ota [10,15,[23][24][25]. The one contralateral lesion similarly arose in the frontal lobe, adjacent to extensive meningeal melanocytosis [22]. These data suggest that malignant melanoma develops in areas where abnormal melanocytes may have been depos ited in the migration from the neural crest to the dermis [15,38].…”