Malignant Melanoma in a Hispanic Male with Nevus of Ota

Shaffer, David R.; Walker, KennethM.; Weiss, Geoffrey R.

doi:10.1159/000247433

Cited by 26 publications

(15 citation statements)

References 18 publications

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“…There are two main complications associated with naevus of Ota: (i) glaucoma 5 as a result of the development of an infiltrate of melanocytes in the iridocorneal angle in 10.3% of cases, and (ii) malignancy, which is rare in Asians. Shaffer et al 6 . commented that of 37 cases of naevus of Ota reported in the English literature, 76% were Caucasians.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Ota naevus

Ruiz‐Villaverde¹,

Melguizo

Eisman

et al. 2003

Acad Dermatol Venereol

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We present the case of a 22-year-old woman, who had presented since the age of 15 a pale-blue spot spread on the right-hand side of her forehead and in her bulbar conjunctiva (first and second branches of the trigeminus nerve), consistent with Ota naevus. A few years later another with similar characteristics appeared on the other side of her forehead, cheek and sclera. No deafness, neurological defect nor visual loss were detected. We comment on the rarity of this case because the patient is Caucasian and also we explain the main complications derived of this disease and consider the therapeutic options.

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Section: Discussionmentioning

confidence: 99%

Bilateral Ota naevus

Ruiz‐Villaverde¹,

Melguizo

Eisman

et al. 2003

Acad Dermatol Venereol

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“…Therefore, the calculated incidence of malignant melanoma associated with the nevus of Ota is 0.001–0.005% (0.2–1.0%×0.5%) among East Asians, whereas it is 0.01% (0.04×25%) among western populations. Malignant melanoma associated with nevus of Ota has been reported to occur in the uveal tract 6, optic nerve head 7, brain, and orbit. As for western populations, Rice and Brown 8 reported finding six cases of primary orbital melanoma associated with nevus of Ota, whereas two other studies have additionally reported two more cases 1,9.…”

Section: Discussionmentioning

confidence: 99%

Animal-type malignant melanoma associated with nevus of Ota in the orbit of a Japanese woman

Nitta¹,

Kashima²,

Mayuzumi³

et al. 2014

Melanoma Research

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We present a patient with an animal-type malignant melanoma associated with the nevus of Ota in the orbit who showed a good prognosis after a combination of orbital extirpation, chemotherapy, stereotactic radiotherapy, and gamma knife. A 42-year-old Japanese woman presented with two tumors, one pathologically diagnosed as right-sided intraconal animal-type malignant melanoma and the other intracranially, presumed to be of the same pathogenesis and both were considered to have arisen from the nevus of Ota. She underwent an extirpation of the orbit, chemotherapy (DAV therapy, which is a combination of dacarbazine, nimustine, and vincristine), stereotactic radiotherapy (54 Gy in 27 fractions), and gamma knife (marginal dose was 17 Gy, target volume was 0.2 ml). She has been alive for 33 months since the extirpation, with no sign of local recurrence, new metastasis, nor enlargement of the intracranial tumor. Not just combination therapy but also the low malignancy of animal-type melanoma may have contributed toward the good prognosis.

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“…Nevus of Ota is widely considered to be a benign dermal melanocytic nevus, but malignant melanoma arising in patients with nevus of Ota has been reported occasionally, mainly in Caucasians. 13 Thus, a question arose as to whether repeated laser damage would increase the risk of malignant transformation. In our study, malignant transformation was not found in any patient.…”

Section: Discussionmentioning

confidence: 99%