Nevus Lipomatosus Superficialis with a Folliculosebaceous Component: Report of 2 Cases

Bancalari, Eugenia; Martínez-Sánchez, Diego; Tardío, Juan C.

doi:10.4061/2011/105973

Cited by 31 publications

(36 citation statements)

References 15 publications

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“…4,7,8 Secondary calcinosis resulting from dystrophic calcification in an NLCS lesion has not been previously reported. 4,7,8 Secondary calcinosis resulting from dystrophic calcification in an NLCS lesion has not been previously reported.…”

Section: Discussionmentioning

confidence: 95%

Nevus Lipomatosus Cutaneous Superficialis With Focal Lipocytic Pagetoid Epidermal Spread and Secondary Calcinosis Cutis

Chopra

Marzooq

Siddiqui

et al. 2015

The American Journal of Dermatopathology

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A case of nevus lipomatosus cutaneous superficialis is presented, wherein the lesion occurred as a gluteal swelling in a 6-year-old boy. On histopathology examination, it consisted of typical superficial expanses of mature adipose tissue in the papillary dermis of the polypoidal lesion. It was accompanied by 2 unusual findings, which consisted of the focal presence of lipocytes at the epidermal–dermal junction in the pagetoid manner and the prominent deposition of calcium resulting in calcinosis cutis–like lesions. Calcinosis cutis in the present case occurred as dystrophic calcification in focal fat necrosis changes of the lesion, whereas the focal pagetoid spread of fat cells is likely related to the same hamartomatous adipose tissue growth that ultimately results in the nevus lipomatosus.

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Section: Discussionmentioning

confidence: 95%

Nevus Lipomatosus Cutaneous Superficialis With Focal Lipocytic Pagetoid Epidermal Spread and Secondary Calcinosis Cutis

Chopra

Marzooq

Siddiqui

et al. 2015

The American Journal of Dermatopathology

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“…These differences made the diagnosis of NLS less certain; however, the presence of follicular or sebaceous structures has been reported in NLS. 4,6 The differential diagnoses in this patient included nevus sebaceous, fibroepithelial polyps, connective tissue nevus, neurofibroma, lymphangioma, hemangioma, tuberous xanthoma, fibrous histiocytoma, or focal dermal hypoplasia (Goltz syndrome). Of these, Goltz syndrome also shows segmental or Blaschko's line distribution.…”

Section: Dear Editormentioning

confidence: 98%

Fibrocollagenous hamartomas with ectopic epithelial and mesenchymal components along Blaschko's line mimicking the classical form of nevus lipomatosus superficialis

Lee

Huang

Yang

et al. 2015

Dermatologica Sinica

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A 19-year-old man presented with multiple asymptomatic lobulated and cerebriform papulonodules and plaques over his left lower trunk that had been present since childhood. The lesions first appeared at the age of 1 month as several tiny red macules over his left lower back and then gradually spread to his abdomen in a linear fashion and became elevated. The lesions progressed more rapidly during his early teens and then remained stationary. There was no relevant family history. A physical examination revealed many soft, erythematous to slightly brownish papules and nodules coalescing into pebbly plaques and soft, cerebriform, polypoid tumors over the left lower trunk in a linear pattern ( Figure 1A and B). Most of the papules had a central umbilication or hair follicular openings ( Figure 1C). There were also some keratinous plugs intermingled with the nodular lesions. All other physical and laboratory examinations were normal. A shave biopsy was performed on a papule ( Figure 1B, arrow) and showed a fibrocollagenous polyp with vertical or intersecting collagen bundles and many small blood vessels in the dermis (Figure 2A), where small clusters of mature fat cells were found around the blood vessels (Figure 2A, inset). In addition, there were a few sebaceous lobules and eccrine glands in the polyp. The findings were suggestive of a hamartoma with epithelial and mesenchymal components. He then underwent curettage and carbon dioxide laser treatment for the complete removal of the skin lesions. Repeated histopathological examination revealed fibrocollagenous polypoid lesions with the presence of sweat glands, sweat ducts, pilosebaceous units ( Figure 2B), and perivascular fat cells within the polyps. The scars remained flat with a few small residual keratinous plugs and draining fistulas eight years after the operation.The clinical and histopathological presentations of this patient were characterized as follows: (1) the skin lesions consisted of umbilicated papules with coalescence into pebbly plaques and large soft polypoid tumors with a cerebriform surface; (2) the lesions showed a distinct linear and blaschkoid pattern; and (3) histology showed polypoid fibrocollagenous lesions with multiple types of epithelial adnexal structures (pilosebaceous and sweat glands) and ectopic adipocytes around superficial blood vessels. The constellation of these findings appears to be unique.Cutaneous polypoid hamartomas with fibrocollagenous stroma in a linear or zosteriform distribution can be seen in the classical form of nevus lipomatosus superficialis (NLS). NLS is categorized into the classical form (HoffmanneZurhelle) and the solitary form. 1 The solitary form has been regarded as a pedunculated lipofibroma. 2 The classical form usually occurs at birth or within the first two decades of life and manifests as skin-colored to yellowish, peau d'orange, cerebriform, or smooth-surfaced papulonodules, often coalescing into segmental or zosteriform plaques. 1 The most common locations are the pelvic girdle, abdomen, back, buttock...

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“…While the relationship between NLCS and trichofolliculoma or FCH remains unclear, this association of two distinct hamartomatous disorders suggests epidermal structures as part of NLCS. [234] The discovery of a case of NLCS with follicular papules and hypertrophic pilo-sebaceous units supports this possibility.…”

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confidence: 99%

“…A peculiar histopathological finding was the association with trichofolliculoma, a hamartoma of pilosebaceous follicles manifesting as small nodules with protruding tufts of hair primarily on the scalp, face, and neck. While we found no other report of the association of NLCS and trichofolliculoma, there have been four NLCS cases associated with folliculosebaceous cystic hamartoma (FCH),[234] a rare cutaneous hamartoma containing follicular, sebaceous, and mesenchymal elements such as ectodermal and mesodermal components.…”

mentioning

confidence: 99%

Nevus lipomatosus cutaneous superficialis associated with trichofolliculoma on the lower leg

2013

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Nevus Lipomatosus Superficialis with a Folliculosebaceous Component: Report of 2 Cases

Cited by 31 publications

References 15 publications

Nevus Lipomatosus Cutaneous Superficialis With Focal Lipocytic Pagetoid Epidermal Spread and Secondary Calcinosis Cutis

Nevus Lipomatosus Cutaneous Superficialis With Focal Lipocytic Pagetoid Epidermal Spread and Secondary Calcinosis Cutis

Fibrocollagenous hamartomas with ectopic epithelial and mesenchymal components along Blaschko's line mimicking the classical form of nevus lipomatosus superficialis

Nevus lipomatosus cutaneous superficialis associated with trichofolliculoma on the lower leg

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