Nevus depigmentosus: Clinical features and histopathologic characteristics in 67 patients

Clinical and histopathologic characteristics of nevus depigmentosus

“…However, sporadic reports have suggested its initial presentation at various ages. 2 In our study, 30.0% of patients recognized ND at birth, but 31.7% of patients had initial lesions after the age of 3 years. Compared with the results of the study by Lee et al 2 in which only 7.5% of patients presented initial lesions after the age of 3 years, more patients showed later development in our study.…”

“…2 Histologic study on lesional skin compared with perilesional normal skin shows a marked reduction in the density of the melanosomes, but variable results in the number of melanocytes. 2,5,6 Knowledge of the clinical and histopathologic changes in ND skin is essential not only to diagnosis but also to understanding the pathogenesis of ND. However, only a few studies 2,7 have been reported.…”

“…3 Clinical diagnostic criteria commonly accepted and proposed by Coupe 4 in 1976 are: (1) leukoderma present at birth or onset early in life; (2) no alteration in distribution of leukoderma throughout life; (3) no alteration in texture, or change of sensation, in the affected area; and (4) no hyperpigmented border around the achromic area.…”

“…2,5,6 Knowledge of the clinical and histopathologic changes in ND skin is essential not only to diagnosis but also to understanding the pathogenesis of ND. However, only a few studies 2,7 have been reported. We investigated clinical and histopathologic features in a large number of patients with ND.…”

“…1 Some authors have reported its initial presentation at various ages, probably because infants or young children have untanned skin and the color contrast of ND lesions may not be readily visible. 2 ND occurs sporadically, and there is no known pattern of inheritance or familial tendency.…”