Nevus comedonicus with Epidermolytic Hyperkeratosis

Aloi, F.; A, Molinero

doi:10.1159/000249006

Cited by 25 publications

(7 citation statements)

References 13 publications

(15 reference statements)

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“…In EHK, a mutation in K1 or K10 interferes with the heterodimeric pairing and gives rise to the characteristic clumping of KIFs in suprabasal layers of the epidermis 14,15 . Although many authors have mentioned the finding of EHK in some lesions of NC, we have found only eight cases reported 3,16–19 …”

Section: Discussionmentioning

confidence: 65%

“…Four cases of NCEHK were reported by Barsky et al, 3 two of which were linear in distribution, and the other two were patchy with extensive skin involvement. In 1987, Aloi and Molinero 19 reported a case of a 7‐year‐old girl who had NCEHK in a band‐like pattern distributed over the right lower limb. Machado et al 16 recently described a similar case of a 15‐month‐old girl who presented with two linear lesions on her thigh.…”

Section: Discussionmentioning

confidence: 99%

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Linear nevus comedonicus with epidermolytic hyperkeratosis

Schecter¹,

Lester²,

Pan

et al. 2004

J Cutan Pathol

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Linear nevus comedonicus with epidermolytic hyperkeratosis

Schecter¹,

Lester²,

Pan

et al. 2004

J Cutan Pathol

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“…Diagnosis is confirmed by the characteristic histopathologic findings. Epidermolytic hyperkeratosis (3) and trichilemmal cysts (4) are associated histopathologic findings. The presence of nodular lesions may indicate trichilemmal cysts.…”

Section: Discussionmentioning

confidence: 99%

Widespread Cribriform Plaques in a Child

Inamadar¹,

Palit²,

Yelikar³

2004

Pediatric Dermatology

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A healthy 11-year-old boy presented with multiple cribriform plaques over different parts of his body. He first developed circumscribed pitted lesions on his left cheek, right ear, right side of his neck, and penis at 4 years of age. With time, they progressively extended, causing cosmetic concern. They were asymptomatic except for occasional expression of cheesy material on pressure. On examination there was a well-defined plaque measuring 7.5 cm × 5 cm on his left cheek, studded with groups of pits filled with black, keratinous plugs (Fig. 1). Similar lesions were found on the right side in a linear pattern extending from his chest to the side of his neck, face, and the concha of his right ear (Fig. 2). Two intradermal nodules were present on the neck. Lesions were also found at the midline of his back and at the penoscrotal junction. The palms, soles, and mucosae were not involved. No other family member was affected. A skin biopsy specimen was taken from a lesion over his right clavicle and stained with hematoxylin-eosin (Fig. 3). WHAT IS YOUR DIAGNOSIS? Diagnosis: Nevus Comedonicus HISTOPATHOLOGYThe epidermis was acanthotic, with deep and wide invaginations filled with concentric lamellae of keratin (Fig. 3). In places, keratin-filled cystic follicles were seen.The basal layer showed abundant melanin and dermal structures were normal. CLINICAL COURSEExcision was advised for a few localized linear lesions. Topical retinoids were tried for the large lesion on his left cheek, without significant improvement, and he is awaiting dermabrasion.

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“…Since 1970, when Ackerman 6 first proposed the idea of incidental EH, many reports of EH have been published including that in association with varied nevi, 7–11 squamous cell carcinoma, 6,12,13 basal cell carcinoma, 8,13 melanoma, 8 epidermolytic acanthoma, 8 seborrheic keratosis, 6,8 scar, 8,14 leukoplakia, 15 and nevus comedonicus 16 . Although EH can be found repeatedly in the literature in association with a number of lesions, it has not been described in association with an infundibular cyst since a report by Mehregan 14 in 1978, which was the first as well as last published report.…”

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confidence: 99%

Epidermolytic hyperkeratosis within infundibular cysts

2006

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Epidermolytic hyperkeratosis (EH) is a well-described histopathologic pattern characteristic of bullous congenital ichthyosiform erythroderma, an autosomal dominant genodermatosis. It is also noted in cutaneous disorders where mosaicism leads to containment of the clinical and histopathologic changes. EH has been observed as an incidental finding in tissue adjacent to and within lesions such as nevi, scars, malignant melanoma, squamous cell carcinoma, basal cell carcinoma, and seborrheic keratoses. We present two cases of EH within infundibular type follicular cysts, a rare finding only once otherwise reported in 1978.

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Nevus comedonicus with Epidermolytic Hyperkeratosis

Cited by 25 publications

References 13 publications

Linear nevus comedonicus with epidermolytic hyperkeratosis

Linear nevus comedonicus with epidermolytic hyperkeratosis

Widespread Cribriform Plaques in a Child

Epidermolytic hyperkeratosis within infundibular cysts

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