NEVIS: Visualization of factors influencing force recruitment in intraneural stimulation. II

Rutten, Wim; Frieswijk, T.A.; Smit, J.P.A.

doi:10.1109/iembs.1994.412004

Cited by 4 publications

(4 citation statements)

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“…Model simulations have confirmed this variation [8], [18]. The results of model studies presented by Meier et al [12] and Frieswijk and Rutten [6] demonstrated that whether or not a nerve fiber is activated by a stimulus with a specific strength, strongly depends on the actual, specific geometrical arrangement of the nodes of Ranvier with respect to the electrode, thus causing differences in recruitment behavior (to be observed best in the low-force range) for different electrode positions. These findings at the same time suggest that selectivity of electrical stimulation can be increased by using as many endoneural electrodes as possible.…”

Section: Introductionmentioning

confidence: 71%

“…The EDL muscle of the rat is innervated by 69 motor fibers in the common peroneal nerve, having an average internodal distance of 1 mm [6], [8], [15]. Assuming the fascicle to be a cylinder with a radius of 250 m, and the nodes of Ranvier to be distributed uniformly inside the fascicle, the -nodal density is 3.5 10 2 mm 3 .…”

Section: Considerations On Theoretical Selectivitymentioning

confidence: 99%

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Endoneural selective stimulating using wire-microelectrode arrays

Smit

Rutten

Boom

1999

IEEE Trans. Rehab. Eng.

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In acute experiments eight 5-to 24-wiremicroelectrode arrays were inserted into the common peroneal nerve of the rat, to investigate whether the electrodes could selectively stimulate motor units of the extensor digitorum longus (EDL) muscle. Twitch-force-recruitment curves were measured from the EDL for each array electrode. The curves were plotted on a double-logarithmic scale and parameterized by the low-force slope (which represents the power p in the power-law relationship of force F versus stimulus current I ; or F I p) and the threshold current. The slopes and threshold currents measured with array electrodes did not differ significantly from those obtained with randomly inserted single wiremicroelectrodes. This indicates that, although involving a more invasive insertion procedure, electrode arrays provide neural contacts with low-force recruitment properties similar to those of single wires. Array results revealed partial blocking of neural conduction, similar to that reported with microneurographic insertion with single needles. The efficiency of the array was defined as the fraction of array electrodes selectively contacting a motor unit and evoking the corresponding threshold force. Efficiency thus expresses the practical value of the used electrode array in terms of the total number of distinct threshold forces that can be stimulated by selecting the appropriate electrodes. The eight arrays were capable of evoking threshold forces selectively with an average efficiency of 0.81 (or 81%).

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Section: Introductionmentioning

confidence: 71%

Section: Considerations On Theoretical Selectivitymentioning

confidence: 99%

Endoneural selective stimulating using wire-microelectrode arrays

Smit

Rutten

Boom

1999

IEEE Trans. Rehab. Eng.

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“…This distribution was constructed by Frieswijk ef al. [2] on basis of literature data from tllree animals [3], [4]. The strengths of the individual motor units are listed in the inset table.…”

Section: Discussionmentioning

confidence: 99%

“…Frieswijk et al [2] constructed an estimated distribution, based on scarce literature data [3], [4]. Basically, this distribution is the product of the diameter distribution presented in logarithmic relationship between cumulative force and the number of recruited motor units [3].…”

Section: Discussionmentioning

confidence: 99%

Intraneural stimulation using wire-microelectrode arrays: analysis of force steps in recruitment curves

Smit

Rutten

Boom

Proceedings of 18th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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-In acute experiments on six Wistar rats, a wiremicroelectrode array was inserted into the common peroneal nerve. A 5-channel array and a 24-channel array were available. Each electrode in the array was used to generate a twitch contraction force recruitment curve for the extensor digitorum Longus muscle. We constructed a histogram of the pooled force steps in all recruitment curves. From a comparison of this experimental histogram with one estimated from literature data, we found that the force steps encountered in our experiments are in the same range as those from the literature-based estimated distribution. Discrepancies between the experimental and the literature-based histogram might be ascribed to an approximation used in the estimated distribution. We conclude that force step histograms appear to provide a simple means for estimating motor unit twitch force distributions, and thus are of value in studies of intraneural selective stimulation.

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