Never‐smokers, never‐drinkers: Unique clinical subgroup of young patients with head and neck squamous cell cancers

Harris, Stephen L.; Kimple, Randall J.; Hayes, D. Neil; Couch, Marion E.; Rosenman, Julian G.

doi:10.1002/hed.21220

Cited by 119 publications

(157 citation statements)

References 35 publications

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“…Some researchers proposed the NSND status had a positive effect on long-term survival for young patients. Harris et al (2010) compared 28 NSND younger patients and 50 SD patients found no difference in 10-year disease free survival rate but an improved 10 year overall survival rates for NSND patients (71% vs. 46%). Durr's study (2013) also concluded the similar trend towards increased survival for never smokers (78.8 months in never smokers vs. 44.7 months in ever smokers).…”

Section: Discussionmentioning

confidence: 90%

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan

Zheng²,

Mao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at a younger age worldwide. Clinical records of 100 patients under the age of 45 years treated specifically for oral cavity SCC in our hospital during a 10-year period were retrospectively analyzed to calculate the survival rates. An obvious male predominance coincided with smoking trend among Chinese young individuals and female patients were more likely to have no traditional risk factors such as smoking or drinking. The 5-year overall survival rate and disease-free survival rate were 61.0% and 75.5%, respectively, consistent with other published series over the decade showing a relatively better survival among the young. No significant differences clearly correlated with outcome when comparing non-smokers non-drinkers to ever-smokers and ever drinkers (P>0.05). Overall survival rate and disease free survival rate was found to be significantly higher in patients with early-stage disease than with advanced stage disease (P=0.001, P=0.009 respectively). The strong influence of clinical stage on prognosis emphasizes the importance of early diagnosis and treatment of oral malignancies for this unique clinical subgroup.

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Section: Discussionmentioning

confidence: 90%

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Fan

Zheng²,

Mao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…As for sample size, the number of participants ranged from 10 to 2,223 young subjects, as described in Table 1. Age distribution of patients varied: individuals considered young were those aged 18-39 years (7,8,10,11) (23.5%), < 30 years (13,20) (3,6,8,9,(11)(12)(13)(14)(16)(17)(18)(19)(20)(21) ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Concerning the relationship with harmful habits, nine investigations demonstrated association between tobacco and/or alcohol use and OSCC, of which six presented positive association (7,10,11,16,18,19) . The other eight did not assess the parameter related to harmful habits ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

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Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Mesquita¹,

Cavalvanti

Nonaka

et al. 2014

J. Bras. Patol. Med. Lab.

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The oral squamous cell carcinoma (OSCC) very often affects subjects above the sixth decade of life. However an increasing incidence has been observed in younger individuals, below 40 years. We conducted a systematized review of the current clinical, histopathological and therapeutic aspects of OSCC in young patients. Our work included studies that addressed OSCC involving young patients in the period 2007-2012, and which were indexed in PubMed. Initially, 499 articles were obtained; after refinement, 340 articles had their titles and abstracts evaluated, with 17 included in the sample. The majority of studies reported male predominance (87.5%), association with tobacco and/ or alcohol use (66.6%), advanced clinical stages at diagnosis (77.7%) and, at histopathology, moderately differentiated tumors (72.7%). Based on the results, we believe there are differences in the factors associated with pathogenesis, biological behavior and prognosis in young patients, since most studies show more rapid and aggressive tumor progression in this age group. We suggest the conduction of research focusing on the pathogenesis and carcinogenesis of OSCC in young patients, thereby searching for better scientific evidence.

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“…Además, la mayoría de los pacientes jóvenes no fumadores ni bebedores son mujeres 18 . Algo que se contradice en el estudio realizado por Llewellyn y cols 12 donde se examinan los hábitos de consumo de alcohol y de tabaco de forma combinada, y se aprecia que sólo el 47% de las mujeres con cáncer de cavidad oral eran no fumadoras y no bebedoras frente al 77% de los hombres de la muestra que cumplían dichas características; siendo esto estadísticamente significativo.…”

Section: Discussionunclassified

Carcinoma escamoso de cavidad oral en paciente menor de edad

Saura

Jariod

Gavin

et al. 2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Never‐smokers, never‐drinkers: Unique clinical subgroup of young patients with head and neck squamous cell cancers

Abstract: Young patients with head and neck squamous cell carcinoma (HNSCC) appear to have unique clinical profiles based on history of alcohol and tobacco abuse.

Cited by 119 publications

References 35 publications

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Carcinoma escamoso de cavidad oral en paciente menor de edad

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