Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia

Cai, Qing-Qing; Wang, Hongwu; Hua, Shan; Tan, Junzhen; Zhou, Tao; Chun-shen, LI

doi:10.1007/s11655-012-1266-9

Cited by 8 publications

(4 citation statements)

References 31 publications

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“…A 0.24 mm diameter nylon filament (tip diameter 0.32 ± 0.02 mm; Beijing Sunbio Biotech, Beijing, China) was inserted into the ICA through the ECA stump and was gently advanced (10 mm) to occlude the origin of the middle cerebral artery. After 1.5 h of MCAO, the filament was removed to restore blood flow (reperfusion) [19]. The rats were then allowed to recover after an incision closure and were housed individually.…”

Section: Methodsmentioning

confidence: 99%

Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative EffectsIn VitroandIn Vivo

Cheng

Lü

Zhong

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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We investigated the effects of baicalin on an ischemia-reperfusion-induced brain injury model in rats and its antioxidative activities in vitro and in vivo. An ischemia-reperfusion injury of the brain via a middle cerebral artery occlusion (MCAO) was induced in rats. Baicalin was injected at different time points (0, 2, 4, and 6 h) after the MCAO was induced. Baicalin can improve neurological function and significantly decrease brain infarction within a time window of 4 h. Moreover, baicalin was able to reduce cell apoptosis and had the strong antioxidative effect of reducing reactive oxygen species production and malondialdehyde generation. In contrast, baicalin interfered with superoxide dismutase and nicotinamide adenine dinucleotide 2′-phosphate oxidase activities. Moreover, baicalin also exhibited strong neuroprotective effects against H2O2-mediated injury and improved the SOD activity of neurons. Furthermore, baicalin demonstrated good scavenging of hydroxyl radicals, superoxide anions, and DPPH radicals and exerted an additional effect of inhibiting xanthine oxidase. Baicalin showed beneficial effects against MCAO-induced injury within a 4 h time window, and its antioxidative effects both in vitro and in vivo may partly elucidate its mechanism of action.

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Section: Methodsmentioning

confidence: 99%

Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative EffectsIn VitroandIn Vivo

Cheng

Lü

Zhong

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…For example, TCM preparations such as Huanshaodan decoction 124 and Tianma Cuzhi granules 125 were found to reduce the N -methyl- d -aspartic acid (NMDA) receptor activity in both cerebral cortex and hippocampus. Single active components, such as sodium tanshione B 45 and senegenin 44 decreased NMDA receptor protein expression and mRNA levels of its NR2B subunit in hippocampus. The classical formula Buyang Huanwu decoction 126 decreased neurological deficit scores via down-regulating AMPA receptors, glutamate receptor-1 RNA and glutamate receptor-2 protein expression.…”

Section: Effects Of Tcm On Brain Injury and Neuron Damage Induced By mentioning

confidence: 96%

“…Using Evan׳s blue dye extravasation and/or brain water content assessment, large doses of TCM preparation, Chinese materia medica, and active compounds were demonstrated to restrain BBB disruption and brain tissue edema after I/R, although the mechanisms for the effects of each TCM may differ. For example, combinations of total alkaloids from Gouteng (Ramulus Uncariae cum Uncis) and Xiatianwu (Rhizoma Corydalis Decumbentis) 101 and the active compound sodium tanshinone B 45 were thought to act through anti-oxidation, whereas the TCM preparation Naomaitong preparation 68 and Guizhi Fuling capsules 67 may produce beneficial effects by anti-inflammatory mechanisms. In contrast, FBD formula 70 and Chinese materia medica Zhimu (Rhizoma Anemarrhenae) 78 may act through inhibition of leukocyte infiltration, whereas the TCM preparation Shexiang Xingnaoning preparation 102 as suggested may act by anti-thrombotic mechanisms.…”

Section: Effects Of Tcm On Brain Injury and Neuron Damage Induced By mentioning

confidence: 99%

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

Sun

Fan

Han

2015

Acta Pharmaceutica Sinica B

193

121

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Ischemic stroke and ischemia/reperfusion (I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species (ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier (BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine (TCM) has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases. In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica, and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage.

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“…Tanshinone IIB significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to MCAO [97]. After tanshinone treatment of rats subjected to MCAO, the levels of glutamate were significantly lower in the hippocampus, and NMDAR1 optical density was reduced in the CA1 region [98].…”

Section: Tanshinone Obtained From Salvia Miltiorrhizamentioning

confidence: 89%

Advances in Herbal Medicine for Treatment of Ischemic Brain Injury

Ghosh¹,

Ghosh²,

Bhat

et al. 2014

Natural Product Communications

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Ischemic brain injury is one of the leading causes of death worldwide and has attracted a lot of attention in the field of drug discovery. Cerebral ischemia is a complex pathological process involving a series of mechanisms, including generation of free radicals, oxidative stress, disruption of the membrane function, release of neurotransmitters and apoptosis. Thrombolytic therapy is the most effective therapeutic strategy, but the benefits are far from being absolute. Increased attention in the field of drug discovery has been focused on using natural compounds from traditional medicinal herbs for neuroprotection, which appears to be a promising therapeutic option for cerebral ischemia with minimal systemic adverse effects that could limit their long term use. The scenario calls for extensive investigations which can result in the development of lead molecules for neuroprotection in the future. In this context, the present review focuses on possible mechanisms underlying the beneficial effects of herbal drugs in patients with cerebral ischemic injury. Natural compounds have been demonstrated to have neurofunctional regulatory actions with antioxidative, anti-inflammatory, calcium antagonizing and anti-apoptotic activities. Among the several leads obtained from plant sources as potential neuroprotective agents, resveratrol, EGb761, curcumin and epigallocatechin-3-gallate have shown significant therapeutic benefits in cerebral ischemic conditions. However, ligustilide, tanshinone, scutellarin and shikonin are the few lead molecules which are under investigation for treatment of cerebral ischemia.

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Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia

Abstract: Preconditioning with STB appears to be a simple and promising strategy to reduce or even prevent cerebral l/R injury and has potential for future clinical application.

Cited by 8 publications

References 31 publications

Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative EffectsIn VitroandIn Vivo

Baicalin’s Therapeutic Time Window of Neuroprotection during Transient Focal Cerebral Ischemia and Its Antioxidative EffectsIn VitroandIn Vivo

Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage

Advances in Herbal Medicine for Treatment of Ischemic Brain Injury

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