Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells.

Bargatze, Robert F.; Kurk, Sandy; Butcher, Eugene C.; Jutila, Mark A.

doi:10.1084/jem.180.5.1785

Cited by 268 publications

(179 citation statements)

References 36 publications

(36 reference statements)

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“…They activate several integrins on leukocytes, including the Pr-integrins (Laudanna et al, 1996). Their receptors belong to the family of rhodopsin-related G-protein-coupled receptors with seven transmembrane helices (Ley et al, 1993;Bargatze et al, 1994).…”

Section: -1 \ P H O S P H a T A S Ementioning

confidence: 99%

Leukocyte Adhesion

Gahmberg

Tolvanen

Kotovuori

1997

European Journal of Biochemistry

207

191

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Leukocyte adhesion is of pivotal functional importance and this has resulted in extensive research and rapid develonient in the field. Leukocyte adhesion involves members of three molecular families: integrins, members of the immunoglobulin superfatnily and carbohydrate binding selectins and sialoadhesins. Recently, considerable structural information on leukocyte integrins and members of the immunoglobulin superfrtinily of adhesion molecules has been obtained. This fact. combined with the identification of several novel adhesion molecules. has increased our understanding o f how they function at the molecular level. Furthermore, the important issue of how integrins are activated to become adhesive is rapidly advancing,.. It is clearly evident that the knowledge accuniulated from basic research will increasingly be applied in clinical medicine. In this review we focus on two iinportant families of adhesion molecules. Norc. This Review will be reprinted in EJR Kei?cw.\ 1997 which will be av;iil;ible in April I99X.A number of different leukocytes are known and most probably more subgroups will be found concomitantly with the development in typing procedures. 111 addition, the cells rnay represent different stages of differentiation. An individual leukocyte m 11 s t be able to interact with a number of fundamentally different cells. often modified in various ways. and sometimes with the extracellular matrix or foreign microbes. These facts may partially be the reason that many different leukocyte adhesion systems and molecules exist. In addition i t is certainly useful for the organism to have a certain redundancy i n adhcsion molecule expression and function. which could seciire vital functions cven if some adhesion functions are lost or weakened.Cellular immunology used to be largely phenomenal and not inolecular. But with the development of monoclonal antibody and inolecular cloning techniques, combined with the rapid advance in structural elucidation. present day immunology is certainly ii molecular science, and in inany respects in the forefiont of modern biomedical research. In fact, a number of dcvelopinents in other fields of present day biomedical research originate from breakthroughs in iinmunology. and an excellent exaniple is leukocyte adhesion. Although much remains poorly understood, adhesion receptor-ligand interactions are now appreciated to such an extent that much can be applied t o several other areas of research.But research on leiikocytc adhesion is not rewarding only from a basic point of view. Undoubtedly. the large interest in this field steins from iiuinerous potential clinical applications. Many of the iniljor diseases affecting mankind. like cardiovnscular disease. stroke, chronic and iicute inflammations. cancer. malaria, and inany bacterial and viral infections directly involve leukocyte adhesion molecules. Therefore. it comes as no surprise

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Section: -1 \ P H O S P H a T A S Ementioning

confidence: 99%

Leukocyte Adhesion

Gahmberg

Tolvanen

Kotovuori

1997

European Journal of Biochemistry

207

191

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“…L-selectin (CD62L) is a leukocyte-expressed adhesion receptor that promotes leukocyte-leukocyte [1][2][3] and leukocyteendothelial cell [4][5][6][7] attachment within the vasculature. L-selectin plays an important role in directing leukocytes to diverse tissue locations that include sites of acute and chronic inflammation and secondary lymphoid organs [8,9].…”

Section: Introductionmentioning

confidence: 99%

Effects of selective protein kinase C inhibitors on the proteolytic down-regulation of L-selectin from chemoattractant-activated neutrophils

Alexander

Kishimoto

Walcheck

2000

Journal of Leukocyte Biology

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The signaling factors that direct the rapid shedding of L-selectin from neutrophils upon chemoattractant stimulation are poorly understood. Protein kinase C (PKC) has been implicated, yet previous studies have relied on the use of phorbol esters and nonselective kinase inhibitors. We treated neutrophils with various selective kinase inhibitors to evaluate their effects on N-formylmethionyl-leucyl-phenylalanine (fMLP)-induced Lselectin shedding. We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP-and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/ CD18) expression, which has been shown not to involve PKC. Other selective serine, threonine, and tyrosine kinase inhibitors were found not to block fMLP-induced L-selectin shedding. These findings provide more definitive evidence for the role of PKC in chemoattractant-induced L-selectin proteolysis. It is interesting that certain highly selective PKC inhibitors, not structurally related to staurosporine, were found to directly induce Lselectin shedding from neutrophils. J. Leukoc. Biol. 67: 415-422; 2000.

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“…This interaction results in neutrophil rolling and subsequent activation of integrin expression, necessary for their adhesion to the endothelium (Norman et al, 2000; , 2007). Increased expression of L-selectin (SELL) by the circulating PMN facilitates their secondary tethering to an already rolling neutrophil (Bargatze et al, 1994;Sperandio et al, 2003). PSGL1 and SELL form a complex, which triggers integrin activation (Stadtmann et al, 2013).…”

Section: Introductionmentioning

confidence: 99%