Neutrophils in antiretroviral therapy–controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment

Campillo-Gimenez, Laure; Casulli, Sarah; Dudoit, Yasmine; Seang, Sophie; Carcelain, Guislaine; Lambert-Niclot, Sidonie; Appay, Victor; Autran, Brigitte; Tubiana, Roland; Elbim, Carole

doi:10.1016/j.jaci.2014.05.040

Cited by 40 publications

(37 citation statements)

References 55 publications

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“…Of note, increased IL-17 production by classical and nonclassical T cells is an increasingly recognized feature in HIV patients. 56,57 In conclusion, we have identified a novel function of PMPs to selectively bind a specialized subset of T H 17-like progenitor cells in the Treg compartment and inhibit their differentiation into potentially pathogenic effector cells. The direct involvement of the cell adhesion molecule P-selectin and its ligand PSGL-1 in this process suggests a role for PMPs in wound healing by participating in the regulation of the required inflammatory response.…”

Section: Discussionmentioning

confidence: 91%

Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin

Dinkla

Cranenbroek

Heijden³

et al. 2016

Blood

104

101

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Section: Discussionmentioning

confidence: 91%

Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin

Dinkla

Cranenbroek

Heijden³

et al. 2016

Blood

104

101

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“…Neutrophils have been demonstrated recently to produce both IL-17 and IL-22 under various inflammatory/infectious conditions (9, 10, 19, 45). However, it is still unclear how neutrophil production of these cytokines is regulated.…”

Section: Discussionmentioning

confidence: 99%

mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production

Chen

Cao

Yao

et al. 2016

The Journal of Immunology

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It has been shown recently that neutrophils are able to produce IL-22 and IL-17, which differentially regulate the pathogenesis of inflammatory bowel disease (IBD). However, it is still largely unknown how the neutrophil production of IL-22 and IL-17 is regulated, and their role in the pathogenesis of IBD. In this study, we found that IL-23 promoted neutrophil production of IL-17 and IL-22. IL-23 stimulated the neutrophil expression of IL-23 receptor as well as rorc and ahr. RORγt and AhR differentially regulated IL-23 induction of neutrophil IL-17 and IL-22. Additionally, IL-23 induced the activation of mTOR in neutrophils. Blockade of mTOR pathway inhibited IL-23-induced expression of rorc and ahr as well as IL-17 and IL-22 production. By utilizing a microbiota antigen specific T-cell mediated colitis model, we demonstrated that depletion of neutrophils, as well as blockade of IL-22, resulted in a significant increase in the severity of colitis, thereby indicating a protective role of neutrophils and IL-22 in chronic colitis. Collectively, our data revealed that neutrophils negatively regulate microbiota antigen specific T cell induction of colitis, and IL-23 induces neutrophil production of IL-22 and IL-17 through induction of rorc and ahr, which is mediated by mTOR pathway.

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“…22 To investigate the senescent C-X-C chemokine receptor type 4 (CXCR4) high /CD62L low neutrophil subset, samples kept on ice were incubated for 45 minutes with phycoerythrin (PE)/cyanine 7 (Cy7)/antihuman CXCR4 (clone 12G5; Sony Biotech, San Jose, CA), PE/antihuman CD11b (clone ICRF44; BD Biosciences, San Jose, CA), and allophycocyanin (APC)/antihuman CD62L (BD Biosciences). 23 Samples were analyzed by flow cytometry.…”

Section: Determination Of Surface Molecule Expression On Resting Neutmentioning

confidence: 99%

Neutrophil hyperactivation correlates with Alzheimer's disease progression

Dong

Lagarde

Xicota

et al. 2018

Annals of Neurology

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106

102

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Our results indicate that the inflammatory properties of circulating neutrophils shift as the percentage of aged neutrophils expands in patients with AD-changes that may play an instrumental role in establishing systemic chronic inflammation. Most important, our data strongly suggest that the neutrophil phenotype may be associated with the rate of cognitive decline and may thus constitute an innovative and prognostic blood biomarker in patients with AD. Ann Neurol 2018;83:387-405.

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Neutrophils in antiretroviral therapy–controlled HIV demonstrate hyperactivation associated with a specific IL-17/IL-22 environment

Cited by 40 publications

References 55 publications

Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin

Platelet microparticles inhibit IL-17 production by regulatory T cells through P-selectin

mTOR Mediates IL-23 Induction of Neutrophil IL-17 and IL-22 Production

Neutrophil hyperactivation correlates with Alzheimer's disease progression

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