Neutrophilic panniculitis associated with myelodysplastic syndromes

Neutrophilic panniculitis with myelodysplastic syndromes presenting as pustulosis: Case report and review of the literature

“…Our patient's papules contained dense neutrophilic infiltrates confined to the subcutaneous fat tissues. This finding was described in a MDS patient in the report by Matsumura et al [2], but the case had multiple erythematous nodules over the left forearm without any pustular lesions.…”

“…Matsumura et al [2] described in 1997 a patient with MDS who developed neutrophilic panniculitis and whose forearm skin lesions were responsive to steroid therapy. Furthermore, plantar pustulosis and palmoplantar pustulosis have been reported with SS [8] and pustular vasculitis [9], respectively.…”

“…Some patients with MDS develop eruptions, which resemble Sweet's syndrome (SS) and pyoderma gangrenosum (PG) [1]. Neutrophilic panniculitis (NP) is another condition that has been reported once before [2]. Cutaneous lesions associated with MDS are classified as either specific or nonspecific [3].…”

Neutrophilic panniculitis

“…Cullity et al 9 in 1991 were the first to use the term "acute febrile NP" or "Sweet's panniculitis." In 1997, the term "neutrophilic panniculitis" appears in an article by Matsumura et al 10 Data on Table II show that in NP, the clinical lesions are always plaques or nodules. They are very frequently localized on limbs; the involvement of the face (1 case) and the trunk (1 case) are rare.…”

“…A careful search of the relevant literature led us to identify 7 previously reported cases of NP. [6][7][8][9][10][11][12] They are summarized in Table II. The first description of NP, to our knowledge, was made in 1982 by Leibowitz et al 6 and was called "Sweet's disease with extension of the inflammatory infiltrate into the subcutaneous fat."…”