Neutrophilenreiches, CD30+ anaplastisches T-Zell-Lymphom in Assoziation mit einer lymphomatoiden Papulose

Abstract

The 2005 EORTC/WHO classification includes three CD30+ lymphoproliferative disorders: 1) primary cutaneous anaplastic large cell lymphoma, 2) lymphomatoid papulosis and 3) borderline cases. These entities may present with many different clinical appearances. Therefore, a precise differentiation among them often is impossible. We present a 40-year-old female who initially presented with a neutrophil-rich, anaplastic CD30+ T cell lymphoma followed by lymphomatoid papulosis.

Pyogenic variant of primary cutaneous CD30+ anaplastic large‐cell lymphoma: Spontaneous remission in a young adult

“…In addition, "borderline" cases exist that exhibit features of both of the aforementioned entities [1][2][3] . In the literature, there have also been cases of a pyogenic lymphoma variant clinically characterized by purulent, fast-growing tumors -similar to an abscess or furuncle -and histologically marked by a particularly prominent neutrophilic infi ltration extending into the subcutis [4][5][6][7][8] . The latter may be so pronounced that it masks the CD30-positive anaplastic cells.…”

“…The clinical fi ndings suggest an aggressive disease course. On the other hand, the condition has an excellent prognosis, with a 5-year survival rate of more than 90 % [ 1,[4][5][6] . Thus, the prognosis of the pyogenic subtype is by no means worse than that of other CLPDs [ 2 ] .…”

“…The high rate of spontaneous resolution of all CD30+ lymphoproliferative disorders has to be taken into account when determining the therapeutic strategy [9][10][11] . In this context, the pyogenic variant makes no exception [ 3,5 ] . After establishing the diagnosis and ruling out systemic lymphoma, a watch-and-wait approach is a very reasonable option [ 2,11 ] .…”