Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio, C-reactive Protein to Albumin Ratio, and Albumin to Fibrinogen Ratio in Axial Spondyloarthritis: A Monocentric Study

Abstract

Background: C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are routinely used to assess disease activity in spondyloarthritis. New biomarkers have been reported, such as neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), CRP to albumin ratio (CAR), and albumin to fibrinogen ratio (AFR). Our study aimed to assess these ratios in spondyloarthritis and to determine the relationship between these ratios and the disease activity. Methods: We conducted a cross-sectional study, including patients with spondyloarthritis. The following ratios were calculated: PLR, NLR, AFR, and CAR. Pearson correlation analysis was carried out to test the correlation of the data. Receiver operating characteristic curves were evaluated for each ratio using ASDASCRP as the gold standard for disease activity. Results: Eighty-five patients were included. The sex ratio was 60 males to 25 females. The mean age was 42.58 ± 11.75 years. There was a positive correlation between the PLR and the following parameters: CAR, CRP, and ESR. A negative correlation was found between AFR and the following ratios: PLR, NLR, CRP, and ESR. The ASDAS correlated negatively with AFR and positively with both PLR and CAR. The cut-offs values of CAR and PLR to distinguish patients with very high disease activity (ASDASCRP>3.5) were 0.442 and 173.64, respectively. Conclusions: Given their good correlation with ESR and CRP, we suggest that PLR, CAR, and AFR can be used as potential indicators of inflammation in spondyloarthritis. The CAR and PLR are useful to identify patients with very high disease activity.

Can Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, or Systemic Immune Inflammation Index Be an Indicator of Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy?

“…We believe that our findings can be explained by the fact that both visceral and somatic pain is prominent in patients undergoing LC. In addition to parameters such as NLR, PLR, and SII, that were evaluated in this study and which are especially useful in predicting inflammatory conditions, indices such as fibrinogen-albumin ratio, c-reactive protein (CRP) albumin ratio, albumin-fibrinogen ratio, erythrocyte sedimentation ratio are further biomarkers [ 22 , 23 ] that require studies for their use in predicting for postoperative pain.…”

C-reactive protein to albumin ratio in Behçet’s disease

“…CAR has been shown to be associated with inflammation in some studies. Recent studies of the CRP/albumin ratio (CAR) have reported that it could be a marker of disease activity in rheumatological diseases [9][10][11][12][13][14][15][16]. Only one study could be found in literature related to CAR in BD patients.…”

“…"-"*%5%-7" " 2;C" &:2;<" ($ 3-+3..4$ " !$>'8?#$ J"%D%%%0$ ='7*43>(,5" ($ 3-1014+$ " !$>'8?#$ J"%D%%%0$ ? @A>(3B@*'" ($ =3-05,+3" Recent studies have been conducted related to CAR in rheumatological diseases such as axial spondyloarthropathy, ANCA-related vasculitis, rheumatoid arthritis, Behcet uveitis, relapsing polychondritis, and Kawasaki disease [9][10][11][12][13][14][15][16]. To the best of our knowledge, there is only one study in the literature related to CAR and BD.…”