Neutrophil to Lymphocyte Ratio (NLR) is a Better Tool Rather than Monocyte to High-Density Lipoprotein Ratio (MHR) and Platelet to Lymphocyte Ratio (PLR) in Central Retinal Artery Occlusions

Güven, Soner; Kılıç, Deniz

doi:10.1080/09273948.2020.1712433

Cited by 18 publications

(17 citation statements)

References 34 publications

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“…According to Sonmez et al [ 13 ], lymphocyte counts can be used as a measure for general bad health and physiological stress. In the present study, we discovered that lymphocyte levels in the RAO and RVO groups were significantly lower than those in the control group, which was consistent with earlier research [ 19 , 22 , 24 , 26 , 43 ]. In this study, lymphocyte levels in the RAO group were likewise considerably lower than those in the RVO group.…”

Section: Discussionsupporting

confidence: 93%

“…Recent research suggests that increased neutrophil counts contribute to tumor growth and metastasis by releasing chemokines (CK) like IL-8, angiopoietin-1, matrix metalloproteinase-9, and vascular endothelial growth factor (VEGF), which are responsible for the formation of macular edema in some retinal vascular diseases [ 32 , 33 ]. In this study, we discovered that neutrophil levels in the RAO group were considerably greater than those in the control group, which is consistent with previous studies [ 24 – 26 ]. Additionally, we discovered that neutrophil levels were significantly higher in the RVO group than in the control group in this study.…”

Section: Discussionsupporting

confidence: 93%

“…The connection between NLR and RVO was revealed ( Table 1 ) [ 19 – 23 ]. Furthermore, the monocyte to high-density lipoprotein ratio (MHR), rather than PLR, may be a useful predictor for the development of RAO [ 24 – 26 ].…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Qin

Zhang

et al. 2022

PLoS ONE

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Aim To evaluate the association between the value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to high-density lipoprotein ratio (MHR) and the development of retinal artery occlusion (RAO) and retinal vein occlusion (RVO). Methods This retrospective study assessed 41 RAO, 50 RVO and 50 control (age and gender matched senile cataract) participants. The NLR, PLR and MHR parameters of patients’ peripheral blood were analyzed. A receiver operating characteristics (ROC) curve analysis and the best cutoff value were used to specify the predictive value of NLR, PLR and MHR in RAO and RVO. Results The NLR, PLR and MHR were significantly higher in RAO group compared to the control group (p<0.001, p<0.001 and p = 0.008; respectively). The NLR, PLR and MHR were also significantly higher in the RVO group compared to the control group (p<0.001, p = 0.001 and p = 0.012, respectively). The NLR and PLR were significantly higher in the RAO group compared to the RVO group (p<0.001 and p = 0.022, respectively). The optimal cut-off value of NLR to predict RAO was >2.99, with 90.2% sensitivity and 100% specificity. The PLR to predict RAO was > 145.52, with 75.6% sensitivity and 80.0% specificity. Conclusion Higher NLR, PLR and MHR are related to the occurrence of RAO and RVO. NLR and PLR are more prominent in RAO compared to RVO.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

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Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Qin

Zhang

et al. 2022

PLoS ONE

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“…These results were also confirmed when the patients were categorized by type of artery occlusion (BRAO or CRAO). Similarly, in a recent retrospective study on 37 CRAO patients and 36 age‐ and sex‐matched controls, NLR was found to be significantly higher in cases and associated with CRAO, with a sensitivity and specificity of 83.8% and 55.6%, respectively (Guven & Kilic 2020). A similar result was reported by Atum & Alagöz (2020) in a survey comparing 46 RAO patients with 51 healthy subjects.…”

Section: Discussionmentioning

confidence: 78%

“…2017b). Furthermore, a recent report has documented higher NLR values in patients with CRAO (Guven & Kilic 2020).…”

Section: Introductionmentioning

confidence: 95%

Complete blood cell count measures in retinal artey occlusions

Pinna

Porcu

Paliogiannis

et al. 2021

Acta Ophthalmologica

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Purpose To investigate the role of complete blood cell count (CBC) measures in retinal artery occlusion (RAO). Methods This was a case–control study, including 73 newly diagnosed RAO patients and 73 sex‐ and age‐matched subjects without RAO. On the same day of RAO diagnosis, a blood sample was collected and CBC was determined using an automatic blood counter. Dimensional CBC indices, such as mean platelet volume (MPV) and red cell distribution width (RDW), and some CBC‐combined indices, including neutrophil/lymphocyte ratio (NLR), derived NLR [dNLR = neutrophils/(white blood cells ‐ neutrophils)] and platelet/lymphocyte ratio (PLR), were evaluated. Erythrocyte sedimentation rate (ESR) was also measured. Results Median neutrophils, red cell distribution width (RDW), NLR and dNLR were 4.5x109/L (IQR = 3.8–5.8), 13.4% (IQR = 12.7–14.75), 2.47 (IQR = 1.85–3.13) and 1.70 (IQR = 1.26–2.18) in RAO patients and 4x109/L (IQR = 3.18–4.93), 12.9% (IQR = 12–14), 1.86 (IQR = 1.42–2.44) and 1.32 (IQR = 1.02–1.64) in controls. RAO patients had significantly higher values of neutrophils (p = 0.003), RDW (p = 0.0011), NLR (p = 0.0001) and dNLR (p = 0.0001). There were no significant differences between the values of white blood cells, lymphocytes, platelet count, MPV and PLR. Multivariate logistic regression models revealed a statistically significant correlation between RAO and increased RDW (OR = 1.36, 95% CI = 1.06–1.73, p = 0.015), NLR (OR = 2.02, 95% CI = 1.34–3.06, p = 0.0009) and dNLR (OR = 3.4, 95% CI = 1.71–6.75, p = 0.0005). Conclusion Results suggest that RDW, NLR and dNLR may be involved in the pathogenesis of RAO and predict its occurrence. However, high‐quality epidemiologic studies, preferably of cohort design, are warranted to confirm whether, or not, an RDW, NLR and dNLR may be considered potential biomarkers of RAO.

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Does systemic inflammation play a role in patients with pterygium?

Kılıç

Güven

2020

Int Ophthalmol

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Neutrophil to Lymphocyte Ratio (NLR) is a Better Tool Rather than Monocyte to High-Density Lipoprotein Ratio (MHR) and Platelet to Lymphocyte Ratio (PLR) in Central Retinal Artery Occlusions

Cited by 18 publications

References 34 publications

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

Complete blood cell count measures in retinal artey occlusions

Does systemic inflammation play a role in patients with pterygium?

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