Neutrophil-to-lymphocyte ratio is involved in the severity of ankylosing spondylitis

Küçük, Adem; Uslu, Ali Uğur; Ugan, Yunus; Bağçacı, Sinan; Karahan, Ali Yavuz; Akarmut, A; Şahin, Ali; Küçükşen, Sami

doi:10.4149/bll_2015_142

Cited by 16 publications

(24 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature, five studies [21][22][23][24][25] showed no significant difference in the NLR when comparing the AS patients with the healthy controls, and similar findings were also obtained with regard to the PLR [21,25,26], which were consistent with the results of this study. However, these results disagreed with the findings of four other studies with regard to the NLR [27][28][29][30] and one study concerning the PLR [24], which might have been related to the involvement of either newly-diagnosed patients with no previous treatment or only patients with active AS in their studies.…”

Section: Discussioncontrasting

confidence: 92%

“…There was a very weak positive correlation between the BASDAI scores and NLR but it was not statistically significant (r = 0.170, p = 0.051). This result was in agreement with the finding of Mercan et al [22] and Gokmen et al [29], but was in contrast to the findings of three other studies [21,28,30]. Meanwhile, there was a weak positive correlation between the PLR and the BASDAI scores, and this result was in agreement with the finding of Esraa et al [21].…”

Section: Discussionsupporting

confidence: 91%

“…3 Correlation between BASDAI scores and neutrophil/lymphocyte ratio in patients with ankylosing spondylitis (p = 0.051) Fig. 4 Correlation between BASDAI scores and platelet/lymphocyte ratio in patients with ankylosing spondylitis (p = 0.012) with the finding of Esraa et al [21] and Kucuk et al [30] that the NLR and PLR were significantly higher in patients with severe disease activity compared to mild disease activity.…”

Section: Discussionmentioning

confidence: 62%

See 2 more Smart Citations

Neutrophil/lymphocyte and platelet/lymphocyte ratios as potential markers of disease activity in patients with Ankylosing spondylitis: a case-control study

et al. 2020

View full text Add to dashboard Cite

Background: The neutrophil/ lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) have the potential to be inflammatory markers that reflect the activity of many inflammatory diseases. The aim of this study was to evaluate the NLR and PLR as potential markers of disease activity in patients with ankylosing spondylitis. Methods: The study involved 132 patients with ankylosing spondylitis and 81 healthy controls matched in terms of age and gender. Their sociodemographic data, disease activity scores using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), and white blood cell, neutrophil, lymphocyte and platelet counts were recorded. The patients with ankylosing spondylitis were further divided according to their BASDAI scores into patients with inactive disease (BASDAI < 4) and patients with active disease (BASDAI ≥4). The correlations between the NLR, PLR and disease activity were analysed. Results: There was a statistically significant difference in the NLR and PLR between the active and inactive ankylosing spondylitis patients (2.31 ± 1.23 vs. 1.77 ± 0.73, p = 0.002), (142.04 ± 70.98 vs. 119.24 ± 32.49, p < 0.001, respectively). However, there was no significant difference in both the NLR and PLR between the healthy control group and ankylosing spondylitis patients (p > 0.05). In addition, the PLR was significantly higher in both the active and inactive groups compared to those in the healthy control group (142.04 ± 70.98 vs. 99.32 ± 33.97, p = 0.014), (119.24 ± 32.49 vs. 99.32 ± 33.97, p = 0.019). The BASDAI scores were positively correlated with the PLR (r = 0.219, p = 0.012) and the NLR, but they were not statistically significant with the later (r = 0.170, p = 0.051). Based on the ROC curve, the best NLR cutoff value for predicting severe disease activity in ankylosing spondylitis patients was 1.66, with a sensitivity of 61.8% and a specificity of 50.6%, whereas the best PLR cutoff value was 95.9, with a sensitivity of 70.9% and a specificity of 55.5%. Conclusion: The PLR may be used as a useful marker in the assessment and monitoring of disease activity in AS together with acute phase reactants such as the ESR.

show abstract

Section: Discussioncontrasting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 62%

See 1 more Smart Citation

Neutrophil/lymphocyte and platelet/lymphocyte ratios as potential markers of disease activity in patients with Ankylosing spondylitis: a case-control study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…[27] The NLR was also studied in SLE patients, and was shown to be correlated with CRP, ESR, and SLE disease activity index scores. [24] However, there have been no studies addressing the NLR in AOSD patients. This is the first report evaluating the NLRs of AOSD patients, including analysis and comparison of clinical features and pre-existing disease activity markers.…”

Section: Discussionmentioning

confidence: 99%

The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease

et al. 2017

View full text Add to dashboard Cite

The neutrophil-to-lymphocyte ratio (NLR) is the proportion of absolute neutrophil count to lymphocytes on routine complete blood count (CBC) tests, and has been studied as a simple marker of the systemic inflammatory response. This study was performed to investigate whether the NLR could be used as a tool to diagnose and predict prognosis in cases of adult-onset Still's disease (AOSD).We retrospectively reviewed 164 patients with suspected AOSD. Among 164 patients with suspected AOSD, 37 patients received another diagnosis (such as viral infection) and were compared with the 127 patients who received a diagnosis of AOSD. Laboratory tests including CBCs, ferritin, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and the NLR were evaluated.AOSD patients showed higher neutrophil counts, lower lymphocyte counts, higher NLRs, and higher levels of ferritin, ESR, and CRP than non-AOSD patients (all P < .001). In receiver operating characteristic (ROC) curve analysis of the NLR for diagnosis of AOSD, the area under the curve (AUC) was highest at 0.967 (95% CI = 0.940–0.993) with a cutoff value of 3.08. The cutoff value showed the greatest sensitivity (91.7%), specificity (68.4%), and AUC value (0.967) as a diagnostic tool for AOSD. The NLR and treatment appeared to be significant prognostic factors for relapse, but only age showed a significant relationship with death. Furthermore, the NLR was significantly higher in patients with macrophage activation syndrome than in hemophagocytic lymphohistiocytosis (HLH) patients (P = .007). In ROC analysis, the NLR with a cutoff value of 5.86 showed a sensitivity of 89.4%, specificity of 87.8%, and AUC of 0.794.The NLR can be used as a diagnostic tool and predictor of relapse in AOSD, and for differential diagnosis of HLH.

show abstract

“…Recently, neutrophil-to-lymphocyte ratio (NLR) as simple, non-invasive and cost-effective marker of infl ammation, is frequently investigated in infl ammatory diseases (5,6) and malignancies (7).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of neutrophil-to-lymphocyte ratio and hematologic parameters in patients with Graves’ disease

Turan¹

2019

BLL

View full text Add to dashboard Cite

AIM: While the ratio of neutrophil-to-lymphocyte (NLR) increases with infl ammation, its importance in Graves' disease is not clear. The aim of this study was to evaluate NLR, a marker of chronic infl ammmation, in Graves' disease. METHODS: 86 Graves' patients (37 before treatment,49 euthyroid patients after treatment) and 112 controls were enrolled. Hematologic parameters, thyroid function tests, age and gender were recorded. NLRs were calculated. Firstly, groups were composed as Graves' group (Group1) and participants without thyroid disorder as control group (Group2). Secondly, Graves' patients before treatment were considered as Group1a, euthyroid Graves' patients after antithyroid treatment were considered as Group1b. These groups were compared with each other in terms of descriptive data and hematological parameters. RESULTS: Lymphocyte, monocyte, platelet, free T3, and free T4 levels were signifi cantly higher in Graves' group than the controls. TSH and NLR were signifi cantly lower in Graves' group Graves' than the controls. Differences among group1a and group1b for monocyte (p = 0.013), for basophil (p= 0.002), for platelet (p = 0.029), and for NLR (p = 0.029) were statistically signifi cant. CONCLUSION: Unlike other infl ammatory diseases, in Graves' disease; hematological parameters may not give information about infl ammatory state of the disease. Therefore, NLR should be evaluated with other serum infl ammatory markers in Graves' disease (Tab. 2, Fig. 1, Ref. 26).

show abstract

Neutrophil-to-lymphocyte ratio is involved in the severity of ankylosing spondylitis

Cited by 16 publications

References 17 publications

Neutrophil/lymphocyte and platelet/lymphocyte ratios as potential markers of disease activity in patients with Ankylosing spondylitis: a case-control study

Neutrophil/lymphocyte and platelet/lymphocyte ratios as potential markers of disease activity in patients with Ankylosing spondylitis: a case-control study

The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease

Evaluation of neutrophil-to-lymphocyte ratio and hematologic parameters in patients with Graves’ disease

Contact Info

Product

Resources

About