Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus

Duman, Tuba Taslamacıoğlu; Aktas, Gülali; Tel, Burçin Meryem Atak; Koçak, Mehmet Zahid; Erkuş, Edip; Şavlı, Haluk

doi:10.4314/ahs.v19i1.35

Cited by 124 publications

(84 citation statements)

References 20 publications

(18 reference statements)

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“…Neutrophil to lymphocyte ratio (NLR) has been found to be associated with glucose control in type 2 diabetes mellitus (T2DM) in recent literature. 11 It is also useful in the differentiation of thyroid nodules, 12 in thyroiditis, 13 in heart failure, 14 in ulcerative colitis, 15 and in alcoholic hepatitis. 16 The inflammatory mediators that secreted by neutrophils can cause vascular wall degeneration.…”

Section: Introductionmentioning

confidence: 99%

<p>Neutrophil–Lymphocyte Ratio (NLR) for Predicting Clinical Outcomes in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus: A Propensity Score Matching Analysis</p>

Shang¹,

Gao²,

Guo³

2020

TCRM

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Background: Cardiovascular diseases (CVD) combined with Type 2 diabetes mellitus (T2DM) frequently occurred. In this study, we aimed at exploring the prognostic significance of blood neutrophil-lymphocyte ratio (NLR) in these types of patients. Patients and Methods: Between June 30, 2010 and August 30, 2017, 1454 patients with CVD were enrolled in this study. Kaplan and Meier methodology was used for survival analysis. We also used propensity score matching (PSM) to further compare survival in patients with or without T2DM. Results: Among all patients, we applied ROC curve analysis to stratify all patients into two different groups including NLR >2.5 (n=432) and NLR≤ 2.5 (n=1022) groups. After that, we further performed survival analysis between different groups. We found that patients with NLR ≤2.5 had significantly favorable OS compared with the overall survival in patients with NLR >2.5. We further built the PSM using 242 pairs of patients who have CVD and with or without T2DM. After adjusting for competing risk factors, we performed Cox proportional hazards models to identify the independent prognostic factors in multivariable adjustment. We found that NLR ≤2.5 (HR: 2.576, 95% CI: 1.241-4.583, P =0.001) and extent of coronary artery disease (HR: 2.432, 95% CI: 1.189-4.392, P =0.005) remained independent predictors of OS. Conclusion: In conclusion, we have established an PSM model and found that a high NLR value was an independent prognostic factor for survival, predicting in patients with both CAD and T2DM. The NLR value would be a valuable biomarker to evaluate the outcomes of patients and give them opportunities for choosing alternative therapies.

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Section: Introductionmentioning

confidence: 99%

<p>Neutrophil–Lymphocyte Ratio (NLR) for Predicting Clinical Outcomes in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus: A Propensity Score Matching Analysis</p>

Shang¹,

Gao²,

Guo³

2020

TCRM

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“…The NLR was also useful in helping differentiate patients with ulcerative colitis from healthy controls 16 . It also plays a role in thyroiditis and is associated with type 2 diabetes 17,18 . RDW is a marker of anisocytosis of the erythrocytes.…”

Section: Introductionmentioning

confidence: 99%

Correlations of disease severity and age with hematology parameter variations in patients with COVID‐19 pre‐ and post‐treatment

Liang

Nong

Jiang

et al. 2020

Clinical Laboratory Analysis

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Background For better understanding of the pathological changes of COVID‐19, benefiting clinical management of the disease and the preparation for future waves of similar pandemics. Methods Hematology parameters from a total of 52 cases of COVID‐19 admitted for treatment in a designated hospital were retrospectively analyzed. Data were analyzed by SPSS statistical software. Results Pre‐treatment T‐cell subsets, total lymphocytes, red blood cell distribution width (RDW), eosinophils, and basophils were significantly lower than that of post‐treatment, while the inflammatory indexes neutrophils, neutrophil to lymphocyte ratio (NLR), and C‐reactive protein (CRP) levels, as well as red blood cell (RBC) and hemoglobin, were significantly reduced after treatment. The T‐cell subsets, total lymphocytes, and basophils in severely and critically ill patients were significantly lower than those in moderately ill patients. Neutrophils, NLR, eosinophils, procalcitonin (PCT), and CRP was significantly higher in severely and critically ill patients than in moderately ill patients. CD3+, CD8+, total lymphocytes, platelets, and basophils in patients older than 50 were lower than that of those younger than 50, while neutrophils, NLR, CRP, and RDW in patients older than 50 were higher than that of younger than 50. There was a positive correlation among prothrombin time (PT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in severely and critically ill patients. Conclusions T‐cell subsets, lymphocyte count, RDW, neutrophils, eosinophils, NLR, CRP, PT, ALT, and AST are important indicators in the management especially for severely and critically ill patients with COVID‐19.

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“…16 The PLR is associated with various conditions, including diabetes mellitus. 17 The NLR is associated with diabetes mellitus, 18 thyroiditis, 19 and thyroid nodules. 20 Similarly, MPV is associated with diabetes mellitus, 21 inflammatory conditions, 22 cardiac conditions, 23 and thyroid conditions.…”

Section: Introductionmentioning

confidence: 99%

Importance of haemogram parameters for prediction of the time of birth in women diagnosed with threatened preterm labour

Tolunay

Elçi

2020

J Int Med Res

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Objective: This study aimed to estimate the importance of complete blood count parameters for predicting the timing of birth in threatened preterm labour cases. Methods: We performed a retrospective study of 92 patients who were diagnosed with threatened preterm labour (24-34 gestational weeks). The patients were divided into two groups according to the time of birth (group 1: delivered within the first week after diagnosis; group 2: delivered later than 1 week). We compared characteristics and complete blood count parameters between these two groups.Results: There were no significant differences in maternal age, body mass index, gravida, parity, haemoglobin levels, and gestational weeks between the two groups. The mean cervical length was 24.24 AE 3.60 mm in group 1 and 30.70 AE 5.32 mm in group 2. There were significant differences in the neutrophil to lymphocyte ratio, white blood cell count, red cell distribution width (RDW), absolute lymphocyte cell count, and absolute neutrophil cell count between the two groups. Conclusion: Maternal serum RDW, the neutrophil to lymphocyte ratio, white blood cell count, absolute lymphocyte cell count, and the absolute neutrophil cell count profile could guide clinicians in predicting the time of birth in threatened preterm labour cases. KeywordsRed cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), preterm birth, delivery, cervical length, white blood cells Date

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Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus

Cited by 124 publications

References 20 publications

<p>Neutrophil–Lymphocyte Ratio (NLR) for Predicting Clinical Outcomes in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus: A Propensity Score Matching Analysis</p>

<p>Neutrophil–Lymphocyte Ratio (NLR) for Predicting Clinical Outcomes in Patients with Coronary Artery Disease and Type 2 Diabetes Mellitus: A Propensity Score Matching Analysis</p>

Correlations of disease severity and age with hematology parameter variations in patients with COVID‐19 pre‐ and post‐treatment

Importance of haemogram parameters for prediction of the time of birth in women diagnosed with threatened preterm labour

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