Neutrophil membrane-coated immunomagnetic nanoparticles for efficient isolation and analysis of circulating tumor cells

Wu, Xianjia; Lin, Zhousheng; Zhao, Chenchen; Liu, Lujie; Zhang, Kelin; Lai, Jialin; Meng, Qian‐Fang; Yao, Gaungyu; Huang, Qinqin; Zhao, Xingzhong; Rao, Lang

doi:10.1016/j.bios.2022.114425

Cited by 20 publications

(21 citation statements)

References 48 publications

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“…Given these obstacles, Li and co-workers developed the nanopathogenoids delivery system (NPNs) based on utter tumor elimination after phototherapy by circulative mechanism (Figure C) . NPNs could be effectively recognized and internalized by neutrophils due to the outer pathogen-associated molecular patterns of OMVs . The deriving chemotaxis neutrophils migrated toward inflamed tumors induced by phototherapy across the blood vessels.…”

Section: Biomaterial-assisted Immunomodulation For Enhanced Icb Therapymentioning

confidence: 99%

“…224 NPNs could be effectively recognized and internalized by neutrophils due to the outer pathogenassociated molecular patterns of OMVs. 225 The deriving chemotaxis neutrophils migrated toward inflamed tumors induced by phototherapy across the blood vessels. Once the rapid release of NPNs from neutrophils in response to inflammatory stimuli, tumor cells subsequently take up NPNs to exhibit anticancer effects.…”

Section: Biomaterial-assisted Immunomodulation For Enhanced Icb Therapymentioning

confidence: 99%

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Boosting Checkpoint Immunotherapy with Biomaterials

et al. 2023

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The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the rapid advances in nanotechnology and materials science, various types of biomaterials have been developed to maximize therapeutic efficacy while minimizing side effects by increasing tumor antigenicity, reversing immunosuppressive microenvironment, amplifying antitumor immune response, and reducing extratumoral distribution of checkpoint inhibitors as well as enhancing their retention within target sites. In this review, we reviewed current design strategies for different types of biomaterials to augment ICB therapy effectively and then discussed present representative biomaterial-assisted immune modulation and targeted delivery of checkpoint inhibitors to boost ICB therapy. Current challenges and future development prospects for expanding the ICB with biomaterials were also summarized. We anticipate this review will be helpful for developing emerging biomaterials for ICB therapy and promoting the clinical application of ICB therapy.

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Section: Biomaterial-assisted Immunomodulation For Enhanced Icb Therapymentioning

confidence: 99%

Section: Biomaterial-assisted Immunomodulation For Enhanced Icb Therapymentioning

confidence: 99%

Boosting Checkpoint Immunotherapy with Biomaterials

et al. 2023

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“…Wu et al used white cell membranes to functionalize magnetic nanoparticles and modify antibodies on the surface of the membrane for the highly sensitive detection of CTCs. 67 The experimental results showed that the modification of the white cell membrane This journal is © The Royal Society of Chemistry 2023 effectively reduces the interference of homologous leukocytes, the capture efficiency of CTCs is increased to 96.82%, the capture purity is 90.68%, and the successful monitoring of clinical blood samples is realized.…”

Section: Biological Properties For Isolationmentioning

confidence: 99%

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

Liu

Cheng

et al. 2023

Lab Chip

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“…[1,2] Therefore, isolation and enumeration of CTCs DOI: 10.1002/adfm.202304426 may play an important role in early cancer diagnosis and treatment progress monitoring. [3,4] In recent years, numerous platforms for the detection of CTCs have been developed to isolate CTCs from whole blood, such as immunomagnetic nanoparticles (IMNs), [5][6][7] antibody-conjugated microfluidic chips, [8][9][10] and size exclusion filtration. [11][12][13] Among them, IMNs have attracted extensive attention owing to their easy manipulation, high capture performance, and rapid isolation.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the JE-CM-MNs would be repelled when they encountered leukocytes in the whole blood owing to their homology. [6,27,28] Given the excellent performance of JE-CM-MNs, the biomimetic nanoparticles could simultaneously achieve high CTC recognition efficiency and enhance antileukocyte binding performance in artificial blood samples. We further confirmed the great potential of this strategy for the clinical detection of CTCs, providing new insight into the application of cancer diagnosis and metastasis monitoring.…”

Section: Introductionmentioning

confidence: 99%

Genetically Engineered Cell Membrane‐Coated Magnetic Nanoparticles for High‐Performance Isolation of Circulating Tumor Cells

Jiang,

Zhang,

Guo

et al. 2023

Adv Funct Materials

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Circulating tumor cells (CTCs) are a crucial biomarker for early cancer diagnosis and progress of cancer metastasis. However, the extremely rare CTCs with large amounts of background leukocytes seriously restricte the purity of enriched CTCs. Herein, genetically engineered cell membrane‐coated magnetic nanoparticles with following properties are constructed: I) The leukocyte membrane camouflaged nanoparticles, which could significantly reduce nonspecific binding of homologous leukocytes and achieve high‐purity isolation of CTCs, are prepared by simple one‐step extrusion and II) the cellular membrane stably expressing single‐chain variable fragment (scFv) of anti‐epidermal growth factor receptor (EGFR) antibody could ensure the recognition of EGFR‐positive CTCs. The binding affinity of the resulting nanoparticles toward extracellular EGFR protein improved more than 100‐fold compared with natural cell membrane‐coated nanoparticles. Furthermore, compared with commercial immunomagnetic nanoparticles, the functional nanoparticles achieved a greater capture efficiency in artificial blood samples and the cell purity increased from 64.8% to 93.5%. Consequently, the authors successfully isolate high pure CTCs from 6 out of 6 cancer patients using engineered cell membrane‐coated nanoparticles. This platform exhibits a promising potential for CTC detection in clinical samples, offering an innovative method for cancer diagnosis and prognosis evaluation.

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Neutrophil membrane-coated immunomagnetic nanoparticles for efficient isolation and analysis of circulating tumor cells

Cited by 20 publications

References 48 publications

Boosting Checkpoint Immunotherapy with Biomaterials

Boosting Checkpoint Immunotherapy with Biomaterials

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

Genetically Engineered Cell Membrane‐Coated Magnetic Nanoparticles for High‐Performance Isolation of Circulating Tumor Cells

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