Neutrophil-Lymphocyte Ratio Predicts Graft Patency Following Lower Limb Revascularisation

Abstract

Post-operative NLR may be a simple, inexpensive means of focussing surveillance resources on patients at high-risk of graft failure. Its value needs to be confirmed in larger cohorts.

The predictive value of elevated neutrophil to lymphocyte ratio for long-term cardiovascular mortality in peripheral arterial occlusive disease

“…This study was the first to show an independent predictive role of high NLR for cardiovascular mortality in both critical limb ischemia and intermittent claudication. In a prospective study of 126 patients with PAOD, who underwent elective or emergency infrainguinal bypass for lower limb revascularization, elevated post-operative NLR was found to be an independent predictor for medium-term graft patency [24]. The prediction of graft failure caused by severe post-operative systemic inflammation had been presented with this study.…”

“…Ergelen et al [10] showed that high NLR value (NLR > 6.97) was associated with increased in-hospital and long-term cardiovascular mortality in patients undergoing primary angioplasty procedures. Moreover, NLR was reported as a strong independent predictor of clinical outcomes including long-term cardiovascular mortality and morbidity after coronary artery bypass grafting [23] and major vascular surgery [24]. The underlying pathophysiology of PAOD is thought to be the mediation of active inflammatory response with neutrophils by numerous biochemical pathways such as releasing of arachidonic acid metabolites and platelet-aggregating factors, cytotoxic oxygen-derived free radicals, and hydrolytic enzymes such as myeloperoxidase, elastase, various hydrolytic enzymes, and acid phosphatases.…”

“…During the course of the present study [median follow-up period of 20 months (IQR, [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]], 75 deaths occurred out of 508 patients (14.8%). The distribution of causes of cardiovascular mortality were as follows: 8 patients with unexplained sudden death, 33 patients with myocardial infarction, 22 patients with decompensated heart failure, 12 patients with hemodynamically significant arrhythmia.…”

Neutrophil–lymphocyte ratio as predictor of mortality and morbidity in cardiovascular surgery: a systematic review

“…Twenty‐one potential papers were included in further review – 16 studies were then excluded: two studies had unclear patient population description with mixture of oncological cases and non‐oncological cases, one study was performed in head and neck cancer patients, four studies were diagnostic in nature, one study had unclear methodology, one study studied had an intermediate outcome, which does not meet the criteria of morbidity, and seven trials were retrospective in nature . Hence, five trials, studying a total of 3487 patients, met all the inclusion criteria (Fig.…”

Does Neutrophil to Lymphocyte Ratio Predict Hospital Stay in Appendectomy Patients?

“…8 Recently, NLR was reported to be a significant predictor of inflammation and presented as useful in the preoperative diagnosis of acute appendicitis. 9 NLR was found to be significantly higher in patients with acute appendicitis compared with those without acute appendicitis. 8,10,11 NLR was also found to be significantly elevated in patients with complicated appendicitis compared with those with uncomplicated appendicitis.…”