Neutrophil–Lymphocyte ratio is associated with arterial stiffness in diabetic retinopathy in type 2 diabetes

Opposite impact of Methylene tetrahydrofolate reductase C677T and Methylene tetrahydrofolate reductase A1298C gene polymorphisms on systemic inflammation

“…Elevated NLR and/or PLR levels were shown to be related with the risks for many diseases or disease outcome. For example, elevated NLR and PLR were shown to associate with DM, complications of DM, prevalence, severity, and prognosis of CAD, severity of lower extremity peripheral artery disease, different types of cancer and cancer prognosis, and also inflammatory disease such as IBD, rheumatoid arthritis . Our results suggest for the first time that MTHFR 677 variants are associated with elevated NLR level, and systemic inflammation is possible pathogenesis for diseases associated with C677T MTHFR polymorphism.…”

Neutrophil-to-lymphocyte ratio in thyroid ophthalmopathy

“…Subsequently, Wang et al studied the NLR and brachial-ankle pulse wave velocity among the diabetic patients without diabetic retinopathy, patients with diabetic retinopathy and healthy subjects. They found out that both parameters were signifi cantly higher in patients with diabetes mellitus and diabetic retinopathy (18). The relationship between NLR and age-related macular degeneration (AMD) was also discussed by researchers.…”

Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients

“…The prognostic significance of PBC-derived ratios in patients with different primary tumors as well as patients affected with non-neoplastic disorders has been reported in numerous prior studies [16][17][18][19][20][29][30][31][32][33][34][35]. It has been demonstrated that serum or urinary concentrations of neopterin represent a valuable biomarker in cancer patients as well as in patients with atherosclerosis [3,4,6].…”

“…Alterations of PBC-derived ratios are encountered in a similar spectrum of different pathologies as in the case of neopterin [16][17][18][19][20][29][30][31][32][33][34][35]. In addition, NLR and CRP have been reported to correlate in cancer patients [42] or patients suffering from the complications of atherosclerosis [41].…”

“…Similarly to cancer, atherosclerosis is accompanied by inflammatory response. Neopterin and PBC-derived ratios have also been reported to represent biomarkers of atherosclerosis and complications accompanying atherosclerosis and to predict the risk of related events [7,[29][30][31][32][33][34][35]. Surprisingly, only limited information is currently available with regard to a correlation or comparison between PBC-derived ratios and other biomarkers of inflammatory response [41,42].…”