Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation

Ertaş, Gökhan; Sönmez, Osman; Turfan, Murat; Kul, Şeref; Erdoğan, Ercan; Taşal, Abdurrahman; Bacaksız, Ahmet; Vatankulu, Mehmet Akıf; Altıntaş, Özge; Uyarel, Hüseyin; Göktekín, Ömer

doi:10.1016/j.jns.2012.09.032

Cited by 75 publications

(61 citation statements)

References 21 publications

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“…In previous studies, elevated RDW served as independent predictor of both 90-day cardiovascular events (HR: 4.610, 95% CI: 1.935-10.981, P = 0.001) [7] and 2-year all-cause mortality (HR: 1.287, 95% CI 1.147-1.445, P b 0.001) [11] in patients with acute HF. NLR, a marker of inflammation, was significantly elevated among patients within the highest RDW quartile in our study, and the relationships between an elevated NLR and death, MI and stroke have previously been demonstrated [27,28]. Our results indicated that both a low BMI and an elevated MCV were independently associated with mortality and that decreased platelet counts were independently associated with the incidence of MAEs.…”

Section: Discussionsupporting

confidence: 78%

The relationship between elevated red cell distribution width and long-term outcomes among patients with atrial fibrillation

Wan

Yang

Zhu

et al. 2015

Clinical Biochemistry

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Section: Discussionsupporting

confidence: 78%

The relationship between elevated red cell distribution width and long-term outcomes among patients with atrial fibrillation

Wan

Yang

Zhu

et al. 2015

Clinical Biochemistry

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“…As a new inflammation marker, NLR represents the balance between neutrophil and lymphocyte levels, which are indicators of systemic inflammation [567891011]. Unlike other inflammatory markers, NLR is simple to calculate, easily applicable in daily practice, and inexpensive.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike other inflammatory markers, NLR is simple to calculate, easily applicable in daily practice, and inexpensive. In addition, a high NLR has been found to be correlated with severity and poor prognosis of several diseases [567891011]. Also, the NLR has been assessed in several studies on eye disease [2021].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, the blood neutrophil to lymphocyte ratio (NLR) has been identified as a potentially useful marker of clinical outcome in inflammatory disease [567891011]. Also, neutrophil-mediated inflammation could play an important role in the pathogenesis of the ischemic disease of the optic nerve, and NLR may be used as a marker to diagnose and assess disease severity for NAION.…”

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confidence: 99%

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Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

Güneş

Yigit

Tök

et al. 2017

Korean J Ophthalmol

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PurposeTo evaluate the neutrophil to lymphocyte ratio (NLR) in patients with nonarteritic anterior ischemic optic neuropathy (NAION).MethodsWe investigated 112 subjects comprising 56 patients with NAION and 56 healthy controls at Süleyman Demirel University. Complete blood count, demographic, and clinic data from NAION patients were evaluated in this study. The NLR was calculated in all individuals and compared between the patient and control groups. Cut-off values were also determined. Then, the relationship between NLR and visual outcomes was investigated.ResultsThe cut-off value for NLR was 1.64. NLR values were significantly higher in NAION patients than in healthy subjects (p < 0.001) and were directly correlated with erythrocyte sedimentation rate levels (r = 0.263, p = 0.006). Also, the NLR value was associated with visual outcomes. Receiver operator characteristic curve analysis revealed a 0.63 area under the curve (confidence interval, 53.7% to 74.1%), 85% sensitivity and 41% specificity at the cut-off NLR value.ConclusionsThe NLR may be a biomarker with good sensitivity that is quick, cost effective and easily detected in serum. It can be used in clinical practice to predict a NAION patient's prognosis in terms of visual outcomes.

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“…In recent years, several studies investigated the potential role of various leukocyte ratios in chronic inflammatory diseases [12][13][14][15]. The inflammatory response is central to the pathophysiology of PTB.…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Inflammatory Marker Levels and Pulmonary Tuberculosis Severity

Abakay

Şen

et al. 2014

Inflammation

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We aimed to investigate the correlation between red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and other inflammatory markers with pulmonary tuberculosis (PTB) severity. Seventy patients with active pulmonary tuberculosis were compared with 50 age-matched and gender-matched healthy controls. The mean age of PTB patients was 50.4±21.8 years. There were no differences in terms of age, gender, and smoking history between PTB patients and controls. Patients with advanced PTB had a significantly higher white blood cell count, neutrophil count, RDW, NLR, and C-reactive protein when compared to patients with mild to moderate PTB. RDW (17.7 versus 15.7 %, p=0.002) and NLR (4.7 versus 3.1, p=0.009) values were higher in patients with advanced PTB as opposed to patients with mild to moderate PTB. NLR and RDW levels may be used as markers of inflammation to help clinically manage patients with TB and to determine disease severity.KEY WORDS: inflammatory markers; neutrophil to lymphocyte ratio; pulmonary tuberculosis; radiological extent; red blood cell distribution width.

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Neutrophil/lymphocyte ratio is associated with thromboembolic stroke in patients with non-valvular atrial fibrillation

Cited by 75 publications

References 21 publications

The relationship between elevated red cell distribution width and long-term outcomes among patients with atrial fibrillation

The relationship between elevated red cell distribution width and long-term outcomes among patients with atrial fibrillation

Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

The Relationship Between Inflammatory Marker Levels and Pulmonary Tuberculosis Severity

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