Neutrophil–Lymphocyte Ratio in Patients With Familial Mediterranean Fever

Celıkbılek, Mehmet; Doğan, Serkan; Akyol, Lutfi; Börekçi, Elif; Zararsız, Gökmen; Kozan, Mustafa; Günaydın, İlhan

doi:10.1002/jcla.21732

Cited by 25 publications

(29 citation statements)

References 16 publications

(26 reference statements)

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“…22,23 Moreover, NLR and MPV had higher levels at the attack periods in familial Mediterranean fever patients. 24,25 High levels of MPV and NLR have been found as a predictor for gastrointestinal bleeding in the Henoch-Schonlein purpura. 26,27 Decreased MPV and NLR have been shown with the treatment of rheumatoid arthritis and ankylosing spondylitis.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

et al. 2017

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Objectives: This study aims to evaluate the role of neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) as activation and inflammatory markers in systemic lupus erythematosus (SLE) patients with nephritis. Patients and methods: A total of 108 SLE patients (8 males, 100 females; mean age 35.3±10.2 years; range 16 to 64 years) including 78 patients with renal involvement (8 males, 70 females; mean age 33.9±10.6 years; range 16 to 64 years) (SLEn+ group) and 30 patients without renal involvement (30 females; mean age 39.1±8.2 years; range 22 to 55 years) (SLEn-group) were included in this retrospective study. All patients' clinical characteristics and laboratory data which include erythrocyte sedimentation rate, C-reactive protein, white blood counts, neutrophil counts, lymphocyte counts, platelet counts, and MPV levels were obtained from medical records. The laboratory data at the highest proteinuria periods of the patients with renal involvement were recorded. Results: Mean MPV (SLEn+ =9.1±2.2, SLEn-=7.9±1.2, p=0.001) and NLR (SLEn+ =5.9±5.9, SLEn-=2.6±2.5, p<0.001) values were significantly higher in lupus nephritis group. Besides, a positive correlation between NLR and C-reactive protein was found in lupus nephritis group (r=1.97, p=0.045). Based on receiver operating characteristic curve with area under the curve of 0.76, cutoff NLR value of 1.93 had 83% sensitivity and 54% specificity [95% confidence interval, 0.66-0.85] in differentiating SLE patients with or without nephritis. Conclusion: Neutrophil to lymphocyte ratio and MPV may be discriminative for lupus nephritis. Also, NLR may be a predictor of lupus nephritis. Both MPV and NLR values may be affected by a great number of factors; therefore, further prospective studies are needed to evaluate the use of these parameters in SLE.

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Section: Discussionmentioning

confidence: 99%

Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

et al. 2017

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“…They reported that the N/L ratio was higher in active FMF than in remission as well as control patients (19). However, they did not find any relationship between active and attack-free periods in terms of WBC counts.…”

Section: Discussionmentioning

confidence: 90%

“…In current study, WBC counts were higher only in patients with compound mutations. In addition, Celikbilek et al (19) reported that the N/L ratio was significantly higher in patients with FMF-related amyloidosis than in patients without FMF-related amyloidosis. Amyloidosis is an important cause of morbidity and mortality in patients with FMF (3).…”

Section: Discussionmentioning

confidence: 99%

“…Celikbilek et al (19) investigated the N/L ratio and WBC counts of FMF patients in active and attack-free periods. They reported that the N/L ratio was higher in active FMF than in remission as well as control patients (19).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies regarding the N/L ratio in FMF in adults have been conducted (8,18,19). But according to our knowledge, no such study has been conducted in children with FMF.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil-lymphocyte ratio in children with familial Mediterranean fever: original article

Duksal¹,

Alaygut²,

Güven³

et al. 2015

Eur J Rheumatol

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Objective: The aim of present study was (a) to evaluate the relationship between the neutrophil/lymphocyte (N/L) ratio and mutation types of familial Mediterranean fever (FMF) in children and (b) to evaluate the relationship between the N/L ratio and age.Material and Methods: Three hundred forty-three children with familial Mediterranean fever in the attack-free period and 283 healthy control children were included in the study. Patients were divided into subgroups according to mutation types. Neutrophil and lymphocyte counts were retrieved from medical records of patients and the N/L ratio was calculated from these parameters. Results:The N/L ratio of patients was found to be significantly higher than that of controls (p<0.001). Among 343 patients, homozygous, heterozygous, and compound mutations were observed in 39, 253, and 51 patients, respectively. The differences in the N/L ratio among patients with homozygous, heterozygous, and compound mutations were not statistically significant. The most common mutations were M694V (n=126), E148Q (n=70), M680I, (n=33), and V726A (n=28). Significant differences were not observed among these mutations in terms of the N/L ratio (p>0.05). In all subjects, there was a weak but significant relationship between age and the N/L ratio (r: 0.215, p<0.001). Conclusion:The N/L ratio, which can be determined by simple methods in routine blood tests, may be used for the follow-up monitoring of chronic inflammation in patients. In addition, the N/L ratio may give an idea to clinicians regarding the early initiation of treatment in patients with typical clinical findings of FMF.

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Comparative analysis of anthropometric indices with serum uric acid in Iranian healthy population

Soori

Rezapoor

Najafimehr

et al. 2022

Clinical Laboratory Analysis

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Serum uric acid (SUA) that is produced by metabolism of purine nucleotides is one of the major hydrophilic antioxidants in human blood plasma and inhibits free radicals. For this reason, there were some theories that increased SUA levels would be beneficial based on its antioxidant activities. [1][2][3][4][5] On the other hand, an increase in SUA levels predicts and correlates with development of conditions associated

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Neutrophil–Lymphocyte Ratio in Patients With Familial Mediterranean Fever

Abstract: Our results demonstrate that N/L ratio is higher in patients with active FMF compared with FMF patients in remission and controls, and a cut-off value of 2.63 can be used to identify patients with active FMF.

Cited by 25 publications

References 16 publications

Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as Inflammatory Indicators in Systemic Lupus Erythematosus Nephritis

Neutrophil-lymphocyte ratio in children with familial Mediterranean fever: original article

Comparative analysis of anthropometric indices with serum uric acid in Iranian healthy population

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