Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography

Bachórzewska−Gajewska, Hanna; Małyszko, Jolanta; Sitniewska, Ewa; Małyszko, J.; Dobrzycki, Sławomir

doi:10.1093/ndt/gfl408

Cited by 86 publications

(75 citation statements)

References 6 publications

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“…The normal uNGAL level in patients undergoing coronary is 11 ± 16 ng/mL. 23 In the present study, the mean 6-hour postoperative uNGAL levels were 20-fold greater for living-donor (229 ± 223 ng/mL) and 70-fold greater for deceased-donor kidney transplants (781 ± 452 ng/mL) ( Table 5). In another recent study in which uNGAL was measured at 6 hours after deceased-donor kidney transplant, the uNGAL level was 640 ng/mL (339.4-2845 ng/mL) in patients who developed delayed graft function and 217 ng/mL (58.1-632.2 ng/mL) in patients who did not develop delayed graft function, and it was concluded that uNGAL may be an accurate predictor of delayed graft function, consistent with the present findings.…”

Section: Discussionsupporting

confidence: 47%

Untitled

Qurashi

Ghamdi²,

Jaradat³

et al. 2014

Exp Clin Transplant

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Objectives: To investigate the predictive value of urinary neutrophil gelatinase-associated lipocalin in the occurrence of delayed graft function after kidney transplant. Materials and Methods: In this prospective cohort study of 67 consecutive patients who received a living-related (40 patients [61%]) or deceased-donor kidney transplant (27 patients [39%]), urinary neutrophil gelatinase-associated lipocalin was determined in the first 100 mL perfusate of the donor kidney and in urine at 6 hours after transplant. Patients were followed (11 ± 7 mo) for changes in estimated glomerular filtration rate and delayed graft function. Results: The mean urinary neutrophil gelatinaseassociated lipocalin level at 6 hours after transplant was significantly higher after deceased-donor (781 ± 452 ng/mL) than living-donor transplant (229 ± 223 ng/mL; P ≤ 0.001). The decrease in estimated glomerular filtration rate from 6 to 12 months after transplant was positively correlated with the urinary neutrophil gelatinase-associated lipocalin levels in the perfusate in living-donor transplant. A significant correlation was noted between the occurrence of delayed graft function and the urinary neutrophil gelatinase-associated lipocalin level at 6 hours after living-donor transplant. In the deceased-donor group, the occurrence of delayed graft function was correlated with urinary neutrophil gelatinase-associated lipocalin levels in the perfusate. In deceased-donor kidney transplant, the mean urinary neutrophil gelatinase-associated lipocalin level in the perfusion fluid was significantly greater from donors who had terminal serum creatinine > 150 μmol/L, and urinary neutrophil gelatinase-associated lipocalin level at 6 hours after transplant was significantly greater in transplants with longer cold ischemia time and donors who had hypertension. Conclusions: Urinary neutrophil gelatinase-associated lipocalin levels in the donor kidney perfusate and 6 hours after transplant may be a useful predictor of delayed graft function and decreased graft function from 6 to 12 months after transplant.

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Section: Discussionsupporting

confidence: 47%

Untitled

Qurashi

Ghamdi²,

Jaradat³

et al. 2014

Exp Clin Transplant

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“…NGAL predicted AKI during cardiac surgery and in an emergency department and was also associated with severity of polycystic kidney disease, IgA nephropathy, and cardiovascular disease. [23][24][25][26] In a previous study from our group, elevated urine NGAL concentrations among kidney transplant recipients on the first posttransplant morning predicted DGF and poor allograft function at 1 year. 17,18 This study showed a very robust association between all five donor urinary biomarkers and donor AKI.…”

Section: Discussionmentioning

confidence: 76%

Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes

Reese

Hall

Weng

et al. 2015

JASN

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Assessment of deceased-donor organ quality is integral to transplant allocation practices, but tools to more precisely measure donor kidney injury and better predict outcomes are needed. In this study, we assessed associations between injury biomarkers in deceased-donor urine and the following outcomes: donor AKI (stage 2 or greater), recipient delayed graft function (defined as dialysis in first week post-transplant), and recipient 6-month eGFR. We measured urinary concentrations of microalbumin, neutrophil gelatinaseassociated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), IL-18, and liver-type fatty acid binding protein (L-FABP) from 1304 deceased donors at organ procurement, among whom 112 (9%) had AKI. Each biomarker strongly associated with AKI in adjusted analyses. Among 2441 kidney transplant recipients, 31% experienced delayed graft function, and mean6SD 6-month eGFR was 55.7623.5 ml/min per 1.73 m 2 . In analyses adjusted for donor and recipient characteristics, higher donor urinary NGAL concentrations associated with recipient delayed graft function (highest versus lowest NGAL tertile relative risk, 1.21; 95% confidence interval, 1.02 to 1.43). Linear regression analyses of 6-month recipient renal function demonstrated that higher urinary NGAL and L-FABP concentrations associated with slightly lower 6-month eGFR only among recipients without delayed graft function. In summary, donor urine injury biomarkers strongly associate with donor AKI but provide limited value in predicting delayed graft function or early allograft function after transplant.

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“…19 Similar, but not identical, results were observed by Mishra J et al who reported a significant rise in serum and urinary NGAL in samples taken after 2 hrs or at the first available sample after cardiopulmonary bypass in children who developed ARF. 20 Another study by Wagener G et al in patients after cardiac surgery demonstrated higher urinary NGAL in patients developing ARF compared to patients without ARF. 21 Recent studies have provided clues toward understanding the role of NGAL in the kidney.…”

Section: Discussionmentioning

confidence: 97%

Serum neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in subjects undergoing percutaneous transluminal coronary angiogram with normal EGFR

Sonagra¹,

Makandar²,

Patnaik³

et al. 2020

IJCBR

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Introduction: Detecting AKI in a timely fashion with the current AKIN staging criteria is a challenge because the diagnosis of AKI is usually based on changes in serum creatinine (SCr) which is a poor marker of early renal dysfunction. Aim: To study the role of Serum Neutrophil Gelatinase-Associated Lipocalcin (NGAL) as early biomarker for the detection of Contrast induced acute kidney injury (CIAKI) in subjects undergoing Percutaneous transluminal coronary angiogram (PTCA) with normal eGFR. Materials and Methods: Prospective cohort study was conducted, where SCr and serum NGAL were serially measured in a heterogeneous group of subjects (n=60) presenting to cardiology department. Results: The study population consisted of 60 subjects. All subjects were divided into 2 groups "CIAKI group" and "no-CIAKI group" according to predefined definition. The serum NGAL increased and reached its peak at 4 hours after contrast media (CM) administration and did not returned to baseline by 24 hours while the SCr increased at 24 hours and reached peak at 48 hours respectively (P<0.001).Thus, 4 hours after CM administration were considered to be appropriate time point for NGAL measurement and there was no significant correlation between serum NGAL with SCr at 0 hours, 4hours, 24 hours and 48hours. Conclusion: In our study, we found that serum NGAL promises to be a simple, safe, non-invasive and reliable early biomarker for predicting possible onset of CIAKI following contrast administration.

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Neutrophil gelatinase-associated lipocalin (NGAL) correlations with cystatin C, serum creatinine and eGFR in patients with normal serum creatinine undergoing coronary angiography

Cited by 86 publications

References 6 publications

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Associations between Deceased-Donor Urine Injury Biomarkers and Kidney Transplant Outcomes

Serum neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in subjects undergoing percutaneous transluminal coronary angiogram with normal EGFR

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