Neutrophil Gelatinase-Associated Lipocalin Levels in Isolated Coronary Artery Ectasia

Akyel, Ahmet; Şahinarslan, Asife; Kızıltunç, Emrullah; Yιldιz, Ümmügülsüm; Alsancak, Yakup; Akboğa, Mehmet Kadri; Yayla, Çağrı; Topal, Salih; Bukan, Neslihan; Özdemir, Murat

doi:10.1016/j.cjca.2011.05.006

Cited by 12 publications

(14 citation statements)

References 23 publications

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“…Serum NGAL has been shown to be elevated in a variety of CAD such as coronary ectasia ( 28 ), coronary slow flow phenomenon ( 29 ), and unstable coronary syndromes, including acute myocardial infarction ( 30 , 31 ). However, the role of NGAL in predicting severity of stable CAD has not yet been clearly elucidated.…”

Section: Discussionmentioning

confidence: 99%

Serum cystatin C and neutrophil gelatinase-associated lipocalin in predicting the severity of coronary artery disease in diabetic patients

Okyay¹,

Yı́ldı́rı́r²,

Cicek³

et al. 2015

Anatol J Cardiol

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Objective:Cystatin C and neutrophil gelatinase-associated lipocalin (NGAL) are biomarkers of renal functions. We evaluated their roles in predicting the severity of coronary artery disease (CAD).Methods:Fifty-two consecutive type 2 diabetic patients (32 males, 65.7±8.6 years) who underwent coronary angiography (CAG) for stable CAD were included in this single-center, prospective, cross-sectional study. Patients with an estimated glomerular filtration rate <60 mL/min/1.73 m2 and with a history of by-pass surgery and/or coronary stent implantation were excluded. The vessel score and Gensini score were calculated to assess the presence and severity of CAD. Mann–Whitney U test, Spearman test, and multiple linear regression analysis were used for the main statistical analyses.Results:Serum cystatin C levels were higher in patients with multivessel disease than in those with single vessel disease [1260 ng/mL (953–1640) vs. 977 ng/mL (599–1114), p=0.017]. According to the median Gensini score, the higher score group also had higher cystatin C levels than the lower score group [1114 ng/mL (948–1567) vs. 929 ng/mL (569–1156), p=0.009]. However, serum NGAL levels were similar between these subgroups. There was a positive correlation between cystatin C and Gensini score (r=0.334, p=0.016). Multiple linear regression analysis revealed serum cystatin C as an independent predictor of the Gensini score (b=0.360, t=2.311, p=0.026). These results may aid in defining cystatin C as a surrogate marker of the extent of CAD in further clinical trials.Conclusion:Serum Cystatin C, but not NGAL levels, could predict the severity of CAD in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Serum cystatin C and neutrophil gelatinase-associated lipocalin in predicting the severity of coronary artery disease in diabetic patients

Okyay¹,

Yı́ldı́rı́r²,

Cicek³

et al. 2015

Anatol J Cardiol

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“…Neutrophils may cause tissue damage and aneurysm formation by secreting elastase, matrixmetalloproteinases (MMP) and oxygen free radicals. Akyel et al found that neutrophil gelatinase-associated lipocalin (NGAL) which is secreted from activated neutrophils is higher in patients with isolated coronary artery aneurysm than normal population (11) . NGAL prevents MMP-9 degradation.…”

Section: Discussionmentioning

confidence: 99%

Ateroskleroza Bağlı Olmayan Koroner Arter Anevrizması ve İnflamasyon İlişkisi

Gürsoy¹,

Hökenek²,

Bakuy³

et al. 2014

Khj

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Coronary artery aneurysm is generally presented as an asymptomatic, incidental angiographic finding and is often associated with atherosclerosis. In this study we investigated the relation of non-atherosclerotic isolated coronary artery aneurysm with inflammation. Patients and Methods: Data of 6845 coronary angiography were retrospectively evaluated. A total of 35 nonatherosclerotic isolated coronary artery aneurysms were diagnosed in 23 patients (0.34%). Patients follow-up charts were reviewed, demographic and hematologic parameters were determined and were compared with the results of 23 healthy subjects. Results: Neutrophil to lymphocyte ratio was 2.44±0.88 in group I and 1.80±0.49 in group II, and the difference was found to be significant (p=0.01). Serum uric acid level was 6.37±1.80 mg/dL in group I and 4.91±0.99 in group II, and the difference was significant (p=0.008). Conclusion: Present study indicates two important triggering factors in the pathogenesis of isolated coronary artery aneurysm; inflammation and oxidative stress. Antiinflammatory and antioxidant treatments may be a new approach in patients with coronary artery aneurysm.

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“…Neutrophils cause damage to the tissue and may play an important role in pathogenesis of CAE by secreting elastase, MMP and oxygen free radicals. [14,15] Akyel et al [16] reported that the protein neutrophil gelatinase-associated lipocalin (NGAL) is increased in patients with isolated CAE. NGAL is secreted from activated neutrophils.…”

Section: Discussionmentioning

confidence: 99%

Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia

2013

Arch Turk Soc Cardiol

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Neutrophil Gelatinase-Associated Lipocalin Levels in Isolated Coronary Artery Ectasia

Cited by 12 publications

References 23 publications

Serum cystatin C and neutrophil gelatinase-associated lipocalin in predicting the severity of coronary artery disease in diabetic patients

Serum cystatin C and neutrophil gelatinase-associated lipocalin in predicting the severity of coronary artery disease in diabetic patients

Ateroskleroza Bağlı Olmayan Koroner Arter Anevrizması ve İnflamasyon İlişkisi

Association of neutrophil to lymphocyte ratio with presence of isolated coronary artery ectasia

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