Ateroskleroza Bağlı Olmayan Koroner Arter Anevrizması ve İnflamasyon İlişkisi

Abstract

Coronary artery aneurysm is generally presented as an asymptomatic, incidental angiographic finding and is often associated with atherosclerosis. In this study we investigated the relation of non-atherosclerotic isolated coronary artery aneurysm with inflammation. Patients and Methods: Data of 6845 coronary angiography were retrospectively evaluated. A total of 35 nonatherosclerotic isolated coronary artery aneurysms were diagnosed in 23 patients (0.34%). Patients follow-up charts were reviewed, demographic and hematologic parameters were determined and were compared with the results of 23 healthy subjects. Results: Neutrophil to lymphocyte ratio was 2.44±0.88 in group I and 1.80±0.49 in group II, and the difference was found to be significant (p=0.01). Serum uric acid level was 6.37±1.80 mg/dL in group I and 4.91±0.99 in group II, and the difference was significant (p=0.008). Conclusion: Present study indicates two important triggering factors in the pathogenesis of isolated coronary artery aneurysm; inflammation and oxidative stress. Antiinflammatory and antioxidant treatments may be a new approach in patients with coronary artery aneurysm.