Neutrophil Gelatinase-Associated Lipocalin as Early Predictor of Acute Kidney Injury After Cardiac Surgery in Adults With Chronic Kidney Failure

Meta-analysis for outcomes of acute kidney injury after cardiac surgery

“…Subsequently, the remaining 103 articles were further reviewed for full-texts, of which 35 lacked of necessary information; 23 were not about AKI and 28 were not related to cardiac surgery. Finally, a total of 17 studies [3,6,10,17–30] were enrolled in this meta-analysis.…”

Conventional or oxygen delivery-guided perfusion: Which comes first, the chicken or the egg?

“…Measurement of other rapid markers of AKI (eg, neutrophil gelatinaseassociated lipocalin) could better provide evidence of the effectiveness of treatment. 2 Third, in our opinion, the subgroup analysis including patients with CPB time between 1 and 3 hours should be further subdivided: there are substantial differences in the risk for AKI between patients undergoing surgery with a short CPB time and those undergoing complex operations with a CPB time of 3 hours. The authors themselves know well how a minute can make the difference in terms of final outcome.…”

Renal disease and the surgical patient: Minimizing the impact

“…Preventive interventions have been studied, but none has been proven effective with CKD who were undergoing cardiac surgery. 39,40 One study found that by using NGAL instead of creatinine, postoperative AKI could be diagnosed an average of 20 hours earlier. 39 In addition, NGAL helped detect renal recovery earlier than creatinine.…”

“…39,40 One study found that by using NGAL instead of creatinine, postoperative AKI could be diagnosed an average of 20 hours earlier. 39 In addition, NGAL helped detect renal recovery earlier than creatinine. 40 The diagnostic cutoff values of NGAL were different for patients with CKD than for those without CKD.…”