2018
DOI: 10.3949/ccjm.85a.17009
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Renal disease and the surgical patient: Minimizing the impact

Abstract: Chronic kidney disease (CKD) is common in patients scheduled for surgery and increases the risk of postoperative acute kidney injury, major adverse cardiac events, and death. Acute kidney injury is a common complication of cardiac and noncardiac surgery and negatively affects both short- and long-term outcomes. If we can detect underlying CKD and other risk factors for acute kidney injury before surgery, we may in theory be able to give preventive therapies and improve perioperative outcomes.

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Cited by 19 publications
(11 citation statements)
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“…19,20 Nevertheless, no prophylactic therapy has been consistently shown to protect against the development of AKI. 21 We do not consider preoperative end-stage renal disease to contraindicate TAAAR; approximately 2% of our patients are receiving RRT at the time of surgery. 1 In our practice, during the past decade, 30 patients on dialysis have undergone TAAAR; these patients had 7% 30-day mortality and 20% operative mortality.…”
Section: Renalmentioning
confidence: 98%
“…19,20 Nevertheless, no prophylactic therapy has been consistently shown to protect against the development of AKI. 21 We do not consider preoperative end-stage renal disease to contraindicate TAAAR; approximately 2% of our patients are receiving RRT at the time of surgery. 1 In our practice, during the past decade, 30 patients on dialysis have undergone TAAAR; these patients had 7% 30-day mortality and 20% operative mortality.…”
Section: Renalmentioning
confidence: 98%
“…Fourth, in the two previous multicenter prospective cohort studies used for the data source in this study [2,3], postoperative complications were observed. However, when the multivariable analysis was performed to assess the associations between AKI and postoperative outcomes, including length of stay, readmission, and in-hospital mortality, only comorbidities, age, American Society of Anesthesiologists physical status classifications and intraoperative bleeding were used as confounders for statistical adjustment.…”
Section: Dear Editormentioning
confidence: 99%
“…First, in the two previous multicenter prospective cohort studies used as data sources in this study [2,3], only serum creatinine was provided for preoperative assessment of kidney function. However, this study used the incidence of chronic kidney disease to define preoperative kidney function impairment.…”
Section: Dear Editormentioning
confidence: 99%
“…Just like the authors had described in the discussion, this is a counterintuitive finding. It is generally believed that a decreased baseline eGFR is a well-established predisposing factor of postoperative AKI and even mild preoperative kidney dysfunction is significant with an increased risk of postoperative AKI [ 2 ]. The authors raised that this counterintuitive finding might be attributable to glomerular hyperfiltration, i.e., a state of little kidney reserve capacity which is intolerable to nephrotoxic insults and prone to the occurrence of AKI.…”
mentioning
confidence: 99%